Well with any other harsher PH, or non liver friendly PS, yes preloading is a must do. With the trifecta stack, its allot less harsher on your body so allot of folks never use any pre loading of a cycle support supp's. With that said, it will not hurt to use it, nor will it hinder your cycle. By all means, you can use it, and use it along with the cycle. Let us know how it goes!