Osta is pretty meh imo. What about Rad and LGD? Those are pretty well touted.
Ostarine by definition of a SARM is worthless. But Ostarine for performance enhancing and bodybuilding is a different story. 20 - 30 mg for an advanced guy won't be enough. However 50 - 60 mg Ostarine (without test), gave me strength and size gains comparable to Tbol/ Hdrol. Side effects obviously were present, but to be expected. I have to look more into this Mk-29, before I start taking it. Apparently they changed the chemical structure by adding an ester. Could just be a sourcing issue though, seeing how Ostarine became illegal in China. But by adding the ester,
it could increase the bioavailability therefore making it more stable in the blood, longer half life, and less side effects.
Rad 140 for sure has clinical application, and still currently in phase one clinical trials for; muscle wasting, osteoporosis, and treatment of AR/ER positive breast cancer. For me though, its only application would be to keep the prostate healthy during times of AAS use. Even the higher dose of Rad, (20 - 30 mg) did nothing for my performance, strength, or size.
Maybe for a first cycle someone could attribute decent gains from this. But RAD will also effect lipid profile and cause liver damage, so IMO the
sides vs gains is not worth it.
Lgd 4033 actually passed clinical trials and currently under development for muscle wasting and osteoporosis. However the highest dose given in clinical setting is only 1 mg. If Viking/ Ligand used 10 mg (muscle building dose), can guarantee you LGD would not have made it past clinical trails. I can't find the exact literature at the moment, but upon metabolic studies done on Lgd 4033 EIGHT metabolites were found. Six of them are not recognized by
any metabolic process found in the body. Not to mention the case study of severe, LGD induced hepatotoxicity. From a college student only taking 10 mg for a mere two weeks. However genetic abnormalties that could have predisposed said individual, were not tested for. Nor the actual product itself.
Since LGD has very little activity at the AR, regardless of its binding affinity; It works instead, through its metabolic pathways by selectively targeting muscle tissue and bone. Personally I wouldn't touch stuff. Last time
I did cycle it though, the side effects were on par with the above research; severe brain fog and lethargy. While the gains in muscle were poor, and strength non existent