how many different ways can we say the same thing...here's one more i suppose. ive applied after morning workout (11ish) and close to bed time (10ish) before and now applying after i wake up (5) and late afternoon (4-5) lethargy doesnt hinder more one way or another. again as the previous posters have said, spread your applications evenly, avoiding contact with bed sheets, clothes, water from showering as long as possible.