Site Specific results are REAL for IGF/AAS

TheGame46

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Ok this is a topic that has a huge division as far as whether site specific gains occur or not. When in fact the answer to this question is such a simple one. Not to insult anyone intelligence though, but it is a very easy concept when you have all the right infomation available to you.

Steroids/AAS/Testosterone are regulated in the body by binding proteins much like IGF. So at any given time only about 2% of the testosterone in your body is free to act on the androgen receptors. The remaining 98% is bound to SHBG (sex hormone binding globulin) and albumin. This bound testosterone is not biologically active. IGF-I has binding proteins that regulate ti as well but the LR3 is much les likly to bcome bound to the the IGF binding proteins.

So lets think of the way we administer these drugs. They are IM injections that go into the blood stream from the injection site. In the case of water based substances like IGF move much faster than oil based AAS but the principle here is going to be the same. The area exposed to the greatest free biologically active compound is going to be the inj site istelf. The further you get from the inj site the lower the blood concentration will be not only b/c its futher from the source and has been dilute further but b/c it has had a change to be bound to binding proteins, degrade, or have already bound to a receptor. So you see you can't deny a site specific effect if you think in terms of receptor saturation. The inj site receptors are going to be far more saturated than those far from it.

All of these drugs are systemic and travel through the blood and effect the entire body but the fact remains the greatest blood concetration is at the inj site. If you inject your left bicep only you right bicep will never expereince the same level of active hormone that the left does. While in the case of water based inj this time period may be more breif the effect is still their reguardless. You must take into account that the quick hitting high concentration of IGF at the inj site is really going to shock the receptors there and this will be way before the body can release more IGFBPs that will be present in the blood in the rest of the body.

On thing to account though is f you keep inkecting the same site day after day, that is going to increase the receptor downregulation significantly more than the rest of the body so you may actaully lose your site specific effect and have an inhibitory effect if proper cycling is not used.

So not to quote VIKI from I-ROBOT. But my logic is undeniable lol. No matter how you look at it site specific activity is un-avoidable. The reason some people may not think they see it is you must remember you only have so many receptors, so you can only saturate so much. In the case of androgen receptors though, there would be a higher site specific upregulation in response to AAS administration for about 6 weeks site specific effects would increase. There are other limiting factors still with satellite cells, gorwth factors etc to consider as well that may make it harder to see. But most likely if one were to make a direct comparison of site inj vs an equally mass/trained muscle you would see a significat effect over the course of 3-6 weeks.

In conclusions, site specifc results are a undenaible reality. How significant is a variable form user to user and conditioned base, but it exist non the less.
 

CHAPS

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I shot tren ace and test prop in my calfs and i noticed a difference in size that has stuck with me. Nothing HUGE but maybe 1/4". It hurt like HELL. I kind literally FEEL stretching. I think the growth was caused by stretching out the fascial tissue and from the big boost in igf-1 and localized mgf production that tren gives. Fast acting esters will produce the biggest spikes in igf-1. Test Prop+SEO would be good.
 
bioman

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Calf shots hurt soooo bad. Ick.

But I do agree about site specificity. It did bring up some lagging areas for my test subject.
 

CHAPS

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It hurt soooooooo bad, and for days after i had calf cramps like you wouldn't believe. I only did the inner head. I'll do a cycle sometime that is only site specific shots and it'll be shorter esters like Tren Ace and Test Suspension. Eventually i'll use SEO, when done correctly it does work and no not that lumpy crap that EVERYONE is soooooo familar with. The problem with SEO is the amount of shots you need to do daily, biceps are 6 shots PER bicep! Chest is 9, you have to shoot 3 across and 3 down so that your actually getting a "lifting" effect and it looks natural. You also must massage the crap out of the injection sites and it's best to train the body part the same day.
 

TheGame46

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If ur gonna do site inj you can always cut it with EO and spread it bilaterally if you dont mine the extra pinning its less painful in the end
 
Evan Bageris

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I think that it is the pressure against the fascia that has the most effect with oil based AAS. Binding proteins like SBGH or Albumen are not limiting factors. We can deal with them and some drugs have no affinity for them anyway....like Trestolone. The steroid has to leave the muscle in order to become active because of it’s Ester. So you shoot Test prop and NPP intyour biceps but they do not activate the receptors there. The test has to find esterase to get it cleaved twice and the NPP three times. So now thatot’s In the bloodstream why would it go back to the prison you put it in. It doesn’t even remember being in your biceps. No, it goes systemic if it is attached to an Ester. Which is everything that wasn’t water based. Now you can get oil based esterlesss anything but I agree that siteys cause growth but I am not sure if it is for the reasons you wrote. But I could be wrong and I am not trying to make you wrong just adding to the discussion. You have a lot of great things to say.
 
Renew1

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I always inject in my glutes. Now my butt is HUGE and incredibly muscular!
 
Evan Bageris

Evan Bageris

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I would love a pic. You are very astute pointing out that I add to these threads that have been dead for years. I am actually not retarded, although my mom says it’s a subjective thing unless it’s like, an extra chromosome at say, pair 21, or FAS. She drinks like a fish but she swears the lobster claw syndrome can be traced directly back to the morning sickness she experienced while I was all up in her and this prescription for nausea that he had unlimited refills on.....the name escapes me.....Thalidamide, maybe....it’s not important. But thank you for pointing that out.
 

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