prostanazol gyno

[bigevan]

this may be a stupid question but i need a little help. i have had a gyno flare up frome past usage on some other things i have taken in the past. I have been using prostanazol with mp, and timax for the last two week. Last wednesday my gyno has started to flare up. Is possible from the prostanazol? i did not think prostanazol could cause this kind of reaction. I have since stoped usage and have started nolvadex. What do you guys think this could be from?

 

[Mr.50]

Here we go again. Another compound that should not cause gyno and we begin with guys running into problems.

this may be a stupid question but i need a little help. i have had a gyno flare up frome past usage on some other things i have taken in the past. I have been using prostanazol with mp, and timax for the last two week. Last wednesday my gyno has started to flare up. Is possible from the prostanazol? i did not think prostanazol could cause this kind of reaction. I have since stoped usage and have started nolvadex. What do you guys think this could be from?

 

[bigevan]

does any one have any idea about this? ALRI can you leave some input on this one?

 

[BKneller]

Not possible from this. There is no way this aromatizes to estrogen. The answer lies somewhere else. This is a 5a reduced compound like DHT. There are no DB's in the A ring.


BK

this may be a stupid question but i need a little help. i have had a gyno flare up frome past usage on some other things i have taken in the past. I have been using prostanazol with mp, and timax for the last two week. Last wednesday my gyno has started to flare up. Is possible from the prostanazol? i did not think prostanazol could cause this kind of reaction. I have since stoped usage and have started nolvadex. What do you guys think this could be from?

 

[DAdams91982]

Sometimes Real world is a little different. Many compounds that there was "No Way" to cause gyno did.

Adams

 

[bigevan]

Well than what can be causing this. I am taking 4 caps mp, 2 caps of trimax, 3 caps gxr, 4 caps lx, and i was taking 3 caps of prostanazol for the last week and a half. i did not think gyno would cause any of this either. Does any one have any side effects from the prostanazol?

 

[jas123]

It's possible that you never fully recovered from a previous cycle. Does prostan cause a rise in prolactin or progest?

 

[KD1]

Well than what can be causing this. I am taking 4 caps mp, 2 caps of trimax, 3 caps gxr, 4 caps lx, and i was taking 3 caps of prostanazol for the last week and a half. i did not think gyno would cause any of this either. Does any one have any side effects from the prostanazol?

I dont know what all those acronyms stand for but thats a lot of stuff you are pumping through your body, it could be anything.

I suggest if you are having issues to simplify. Take one product, then do PCT with one product. Then try something else next time if that was not sufficient, or just to shake up your body. If you find a product that gives you sides, stop, go on PCT, never use it again.

 

[Carl Hungus]

this may be a stupid question but i need a little help. i have had a gyno flare up frome past usage on some other things i have taken in the past. I have been using prostanazol with mp, and timax for the last two week. Last wednesday my gyno has started to flare up. Is possible from the prostanazol? i did not think prostanazol could cause this kind of reaction. I have since stoped usage and have started nolvadex. What do you guys think this could be from?

I've been using p-zol for 25 days---no gyno here. The other products you're on shouldn't be causing your problem either, though.

 

[sandman]

I've been using p-zol for 25 days---no gyno here. The other products you're on shouldn't be causing your problem either, though.

CH, what's your opinion on P-zol thus far? Sorry for the hijack...

 

[bigevan]

i was getting a very good response from the p-zol. I was getting leaner and harder. Everything was good until the gyno flare up. I have no idea why this is happening. I think i am going to wait several weeks and run it again with some nolvadex.

 

[RAVEN]

Can you give me a list of EVERYTHING you took with your cycle?

i was getting a very good response from the p-zol. I was getting leaner and harder. Everything was good until the gyno flare up. I have no idea why this is happening. I think i am going to wait several weeks and run it again with some nolvadex.

 

[Author L. Rea]

Well than what can be causing this. I am taking 4 caps mp, 2 caps of trimax, 3 caps gxr, 4 caps lx, and i was taking 3 caps of prostanazol for the last week and a half. i did not think gyno would cause any of this either. Does any one have any side effects from the prostanazol?

I do not post on boards much and have to apologize, but could you please tell me what the other products abbreviations are? I am sorry, I really do not keep up on much that other companies do.

 

[Ant.]

MP= Melting Point
GXR= Glucophase
LX= Lean extreme

I do not post on boards much and have to apologize, but could you please tell me what the other products abbreviations are? I am sorry, I really do not keep up on much that other companies do.

 

[Syr]

this may be a stupid question but i need a little help. i have had a gyno flare up frome past usage on some other things i have taken in the past. I have been using prostanazol with mp, and timax for the last two week. Last wednesday my gyno has started to flare up. Is possible from the prostanazol? i did not think prostanazol could cause this kind of reaction. I have since stoped usage and have started nolvadex. What do you guys think this could be from?

I think the cause lies on what you took in the past. Which was your previous cycle and how long ago did u finish it? Also, which was your pct?
Nothing of what you are currently taking could contribute to gyno.
For ALR:
MP - melting point, a fatty acid complex
GXR - glucophase xr, k-r-ala, quercetin, biotin and something else to enhance it
LX - lean xtreme, 7OH-DHEA
Trimax - triaticol

 

[Syr]

It's possible that you never fully recovered from a previous cycle. Does prostan cause a rise in prolactin or progest?

Max could, but Prostan shouldnt. Rea?

 

[Author L. Rea]

I think the cause lies on what you took in the past. Which was your previous cycle and how long ago did u finish it? Also, which was your pct?
Nothing of what you are currently taking could contribute to gyno.
For ALR:
MP - melting point, a fatty acid complex
GXR - glucophase xr, k-r-ala, quercetin, biotin and something else to enhance it
LX - lean xtreme, 7OH-DHEA
Trimax - triaticol

Simple, check your zinc and vitamin-e intake (800iu daily of the water soluable vit-E works rather well) and be sure the level of potasium is not to high as it tends to screw up zinc activity and absorption. All of which mediates the AR. And of course, read below.

Mol Nutr Food Res. 2005 Jun 6Mol Nutr Food Res. 2005 Jun 6

[size=+1]The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor.[/size]

Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.

Division of Toxicology, Wageningen University, Wageningen, The Netherlands. Fax: +31-317-484931.

Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated. For this purpose, the effect of quercetin on cell proliferation was tested in ER-positive MCF-7 and T47D cells, and in ER-negative HCC-38 and MDA-MB231 cells. Quercetin stimulated proliferation of ER-positive cells only, suggesting this effect to be ER-dependent. In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein. Quercetin activated the ERbeta to a 4.5-fold higher level than E2, whereas the maximum induction level of ERalpha by quercetin was only 1.7 fold that of E2. These results point at the relatively high capacity of quercetin to stimulate supposed 'beneficial' ERbeta responses as compared to the stimulation of ERalpha, the receptor possibly involved in adverse cell proliferative effects. Altogether, the results of this study reveal that physiologically relevant concentrations of quercetin can exert phytoestrogen-like activity similar to that observed for the isoflavonoid genistein.

 

[323mattb]

Simple, check your zinc and vitamin-e intake (800iu daily of the water soluable vit-E works rather well) and be sure the level of potasium is not to high as it tends to screw up zinc activity and absorption. All of which mediates the AR. And of course, read below.

Mol Nutr Food Res. 2005 Jun 6Mol Nutr Food Res. 2005 Jun 6

[size=+1]The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor.[/size]

Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.

Division of Toxicology, Wageningen University, Wageningen, The Netherlands. Fax: +31-317-484931.

Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated. For this purpose, the effect of quercetin on cell proliferation was tested in ER-positive MCF-7 and T47D cells, and in ER-negative HCC-38 and MDA-MB231 cells. Quercetin stimulated proliferation of ER-positive cells only, suggesting this effect to be ER-dependent. In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein. Quercetin activated the ERbeta to a 4.5-fold higher level than E2, whereas the maximum induction level of ERalpha by quercetin was only 1.7 fold that of E2. These results point at the relatively high capacity of quercetin to stimulate supposed 'beneficial' ERbeta responses as compared to the stimulation of ERalpha, the receptor possibly involved in adverse cell proliferative effects. Altogether, the results of this study reveal that physiologically relevant concentrations of quercetin can exert phytoestrogen-like activity similar to that observed for the isoflavonoid genistein.

Wow. I was taking GXR (containing Quercetin) when I was on the Ergomax cycle and experienced nipple sensitivity. Do you see a connection? Keep in mind, 5 days post Ergo, estradiol was 139 (also this was day 8 of Novedex).

 

[Author L. Rea]

Wow. I was taking GXR (containing Quercetin) when I was on the Ergomax cycle and experienced nipple sensitivity. Do you see a connection?

The combination of potassium and quercetin certainly would have the "potential" to cause this in those with high concentrations of ER in the nipple area, but knowing DS I find it unlikely the dosing is of this level for most users.

 

[323mattb]

The combination of potassium and quercetin certainly would have the "potential" to cause this in those with high concentrations of ER in the nipple area, but knowing DS I find it unlikely the dosing is of this level for most users.

Whew...
Thanks for the response. GXR will continue to be my ALA of choice.

 

[Author L. Rea]

Whew...
Thanks for the response. GXR will continue to be my ALA of choice.

Like any product there will always be some that do less well with them than others. If you feel you are having a gyno type response and you are not using a progestin or aromatizing product, then eliminate the others to better evaluate.

 

[bigevan]

this is interesting but i still do not see how my gyno flared up. i have not cycled in quite some time.

 

[WheyGood]

The Trimax is supposed to elevate natural testosterone production, right?
Elevated test levels alone could be contributing to gyno ... let alone slightly elevated test levels on top of everything else (and the previous cycles).

Some people say Tribulus doesn't do much, but I've used it a few times over the years and 'felt' like it helped bring up test production (never had blood work done to confirm this though...).

 

[Mr.50]

No Trimax is tiratricol. T3 analog. As far as the GXR is concerned, while quercitin may contribute to gyno in some way I still got some gyno symptoms on Ergomax and I was not on any GXR, etc.


Author any additional feedback based on the list of supplements I was taking that I sent to Raven.

Mr.50

 

[Anarchy939]

Would it be safe to say that GXR should not be run on cycle if it indeed causes high estradiol? This is interesting to me too, because my estradiol always seems to skyrocket no matter what compound I take. All of those times I was on GXR...

 

[Bobby Nevada]

I'd like to see some pics. Also, what is your bf%?

 

[bigevan]

I am about 10%. I do not have any pics but i can tell you it is gyno because i have been to the doctor in the past. It is not as senstive since i have started nolvadex and since i have stopped takling the prostan.

I'd like to see some pics. Also, what is your bf%?

 

[Robboe]

Simple, check your zinc and vitamin-e intake (800iu daily of the water soluable vit-E works rather well) and be sure the level of potasium is not to high as it tends to screw up zinc activity and absorption. All of which mediates the AR. And of course, read below.

Mol Nutr Food Res. 2005 Jun 6Mol Nutr Food Res. 2005 Jun 6

[size=+1]The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor.[/size]

Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed, Invalid Link Removed.

Division of Toxicology, Wageningen University, Wageningen, The Netherlands. Fax: +31-317-484931.

Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated. For this purpose, the effect of quercetin on cell proliferation was tested in ER-positive MCF-7 and T47D cells, and in ER-negative HCC-38 and MDA-MB231 cells. Quercetin stimulated proliferation of ER-positive cells only, suggesting this effect to be ER-dependent. In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein. Quercetin activated the ERbeta to a 4.5-fold higher level than E2, whereas the maximum induction level of ERalpha by quercetin was only 1.7 fold that of E2. These results point at the relatively high capacity of quercetin to stimulate supposed 'beneficial' ERbeta responses as compared to the stimulation of ERalpha, the receptor possibly involved in adverse cell proliferative effects. Altogether, the results of this study reveal that physiologically relevant concentrations of quercetin can exert phytoestrogen-like activity similar to that observed for the isoflavonoid genistein.

There are also studies showing quercetin exerting an anti-estrogenic effect at the cellular level.

 

[Robboe]

Not possible from this. There is no way this aromatizes to estrogen. The answer lies somewhere else. This is a 5a reduced compound like DHT. There are no DB's in the A ring.

Bruce, are there any metabolites of the product that may cause such an effect?