MetalMX
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What are peoples opinions on using Metaformin to improve insulin resistance?
Last time i did a glucose tolerance test i had very high insulin but normal glucose (insulin resistance), this is because i have low T, poor adrenal function and hypothyroidism.
Metformin is a biguanide (a hypoglycemia-inducing drug) that has been demonstrated to decrease hepatic glucose production and improve peripheral insulin sensitivity. Metformin benefits individuals with diabetes by:
Decreasing hepatic glucose production;
Reducing hyperglycemia;
Reducing lipid levels (eg, triglycerides);
Facilitating postreceptor transport of insulin; and
Facilitating weight loss.[3-6]
Each of these benefits of metformin leads to a physiological environment in which peripheral insulin sensitivity is improved, and insulin resistance is reduced.
Insulin resistance is associated with obesity. The use of metformin in obese nondiabetic individuals has been a subject of empirical inquiry and has significant implications for practice.[5,7-9] Research in this area holds promise for early identification, intervention, and treatment of individuals at risk for developing diabetes mellitus.
Trends in clinical practice within the past year have been directed toward early diagnosis and treatment of individuals with impaired glucose; generally, those who are obese, sedentary, and elderly. Early diagnosis and management of impaired glucose (fasting glucose levels > 110 mg/dL[10]), is a clinical strategy to delay the onset and progression of diabetes, as well as the development of micro-and macrovascular complications
Metformin dosing:
500 mg twice daily, initially, then titrated every 1-2 weeks, increasing the dosage by 500 mg. If 850 mg tablets are used to initiate therapy, it is begun as once-daily dosing and titrated to a maximum of 850 mg 3 times daily.
Maximum dose 2550 mg in divided doses, lower for elderly patients
Last time i did a glucose tolerance test i had very high insulin but normal glucose (insulin resistance), this is because i have low T, poor adrenal function and hypothyroidism.
Metformin is a biguanide (a hypoglycemia-inducing drug) that has been demonstrated to decrease hepatic glucose production and improve peripheral insulin sensitivity. Metformin benefits individuals with diabetes by:
Decreasing hepatic glucose production;
Reducing hyperglycemia;
Reducing lipid levels (eg, triglycerides);
Facilitating postreceptor transport of insulin; and
Facilitating weight loss.[3-6]
Each of these benefits of metformin leads to a physiological environment in which peripheral insulin sensitivity is improved, and insulin resistance is reduced.
Insulin resistance is associated with obesity. The use of metformin in obese nondiabetic individuals has been a subject of empirical inquiry and has significant implications for practice.[5,7-9] Research in this area holds promise for early identification, intervention, and treatment of individuals at risk for developing diabetes mellitus.
Trends in clinical practice within the past year have been directed toward early diagnosis and treatment of individuals with impaired glucose; generally, those who are obese, sedentary, and elderly. Early diagnosis and management of impaired glucose (fasting glucose levels > 110 mg/dL[10]), is a clinical strategy to delay the onset and progression of diabetes, as well as the development of micro-and macrovascular complications
Metformin dosing:
500 mg twice daily, initially, then titrated every 1-2 weeks, increasing the dosage by 500 mg. If 850 mg tablets are used to initiate therapy, it is begun as once-daily dosing and titrated to a maximum of 850 mg 3 times daily.
Maximum dose 2550 mg in divided doses, lower for elderly patients
