Hemerocallis fulva

Synapsin

Synapsin

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Hemerocallis fulva



History

Hemerocallis Fulva (HF), commonly referred to as the orange Daylilys, is native to Asia but is also found in North America. These flowering plants grow to be over 50 cm tall, and have large leaves (1). The flowers of Hemerocallis Fulva are commonly used for cooking in Asian cuisine, and are referred to as golden needles (2). It is well established at the flowers of Hemerocallis fulva are not toxic, as it has been used in culinary use since ancient times in Asia (3).

Effects

A 2013 rat study on an ethanol extract of Hemerocallis fulva revealed some interesting anti-depressant properties. They found that Hemerocallis fulva significantly increased levels of 5-HT, NE, and DA in the frontal cortex, the HC, the striatum, and the amygdala (4). Long term results of this paper found increased [5-HT] and a reduced turnover of 5-HT in all of these brain areas (minus the frontal cortex). Another study on Hemerocallis fulva have revealed a variety of caffeoylquinic acids and flavonoids present in their flowers, making it potentially an effective anti-oxidant (5).

The most interesting study on Hemerocallis fulva for those reading this, however, will be the cell study on its fat loss properties (6). Hemerocallis fulva in the presence of norepinephrine increased amounts of cAMP molecules (note, increased amount of cAMP molecules is not the same as increased levels of intracellular cAMP production). Increased levels of cAMP, as most of you will recall, is the proposed mechanism of what is widely considered to be the best non stimulant fat loss ingredient on the market, Forskolin (for additional info, look at mr.cooper’s informative threads on forskolin; there are plenty of them!). Since I am sure some of you will be curious about whether or not stacking an ingredient like Forskolin and HF is a good idea, the answer is that they stack quite nicely:



In addition, this study also found that this effect was further enhanced when combined with a phosphodiesterase inhibitor. A very common phosphodiesterase inhibitor is caffeine (7-8). This essentially means that if you were to combine Hemerocallis fulva with caffeine and an ingredient that increases levels of norepinephrine, (yohimbine or synephrine [much weaker effect than yohimbine]) the combination of the three leads to more glycerol being released via fat cells releasing their fatty acids (via lipolysis, the breakdown of fat). This means that PES SHIFT would be effective on its own (combination of Hemerocallis fulva, forskolin, and synephrine), and even more effective when combined with a product that contains caffeine and yohimbine (such as alphamine or norcodrene).



The authors of this paper propose that Hemerocallis fulva can increase the effects of PKA related intra-cellular signaling pathways and modify the effects of lipolysis in the presence of other ingredients.

Toxicity

A study using a 30 mg/kg (HED in a 70 kg human is over 340 mg) extract of the flowers of Hemerocallis fulva in rats showed no adverse effects (4).

Summary

Hemerocallis fulva, known as the orange daylily is a plant with a variety of effects. It is thought to possess anti-depressant, anti-oxidant, and lipolytic properties, although these effects have yet to be confirmed in human studies.

1. Hemerocallis fulva. Flora of China.
Hemerocallis fulva in Flora of China @ efloras.org

2. TAWNY DAYLILY. Hemerocallis fulva http://www.oardc.ohio.state.edu/weedguide/singlerecord.asp?id=180

3. Orange Day Lily. Hemerocallis fulva Lily family (Liliaceae)
Orange Day Lily (Hemerocallis fulva)

4. Lin, S., et al. (2013). The Antidepressant-like Effect of Ethanol Extract of Daylily Flowers ( Jīn Zhēn Huā) in Rats. J Tradit Complement Med. 3(1):53-61.

5. Lin, Y. L., Lu, C. K., Huang, Y. J., & Chen, H. J. (2011). Antioxidative caffeoylquinic acids and flavonoids from Hemerocallis fulva flowers. Journal of Agricultural and Food Chemistry, 59(16), 8789-8795.

6. Mori, S., Takizawa, M., Satou, M., Sakasai, M., Kusuoku, H., Nojiri, H., Yoshizuka, N., et al. (2009). Enhancement of lipolytic responsiveness of adipocytes by novel plant extract in rat. Experimental biology and medicine (Maywood, N.J.), 234(12), 1445-1449.

7. Howell, L. L. (1993). Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 266(2), 894-903.

8. Boswell-Smith, V., Spina, D., & Page, C. P. (2006). Phosphodiesterase inhibitors. British journal of pharmacology, 147 Suppl 1, S252-S257.
 

kdubson14

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Those are pretty. I'm going to look into them for our garden. (serious)
 
bdcc

bdcc

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Awesome writeup. :)
 
kbayne

kbayne

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Great write-up.

Clear and very easy to understand.
 
money0351

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Nice! Makes me want to run the shift I have in my stash already!
 
breezy11

breezy11

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Great job with the write-up, Synapsin.
 
schizm

schizm

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Think I have some of those growing in my backyard...gonna go eat em to find out..and then plant a coleus forskolii plant... :balla:
 
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