Ghrp-6

idunk42

King Kong
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Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones

Frago,-L-M [Author,-Reprint-Author]; Paneda,-C [Author]; Argente,-J [Author]; Chowen,-J-A [Author]

Journal-of-Neuroendocrinology.

Chronic systemic administration of growth hormone (GH)-releasing peptide-6 (GHRP-6), an agonist for the ghrelin receptor, to normal adult rats increases insulin-like growth factor (IGF)-I mRNA and phosphorylated Akt (pAkt) levels in various brain regions, including the hypothalamus. Because neuropeptide Y (NPY) neurones of the arcuate nucleus express receptors for ghrelin, we investigated whether these neurones increase their IGF-I and p-Akt levels in response to this agonist. In control rats, immunoreactive pAkt was practically undetectable; however, GHRP-6 increased p-Akt immunoreactivity in the arcuate nucleus, with a subset of neurones also being immunoreactive for NPY. Immunoreactivity for IGF-I was detected in NPY neurones in both experimental groups. To determine if activation of this intracellular pathway is involved in modulation of NPY synthesis RCA-6 cells, an embryonic rat hypothalamic neuronal cell line that expresses NPY was used. We found that GHRP-6 stimulates NPY and IGF-I mRNA synthesis and activates Akt in this cell line. Furthermore, inhibition of Akt activation by LY294002 treatment did not inhibit GHRP-6 induction of NPY or IGF-I synthesis. These results suggest that some of the effects of GHRP-6 may involve stimulation of local IGF-I production and Akt activation in NPY neurones in the arcuate nucleus. However, GHRP-6 stimulation of NPY production does not involve this second messenger pathway.
 
pb2xtreme1

pb2xtreme1

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so can someone cantrast this to ectotropin? is ecto anti GHRP-6? not very sure?
 

idunk42

King Kong
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Both ecto and hexa each contain 2.0mg of cell mediated GHRP-6.
 
pb2xtreme1

pb2xtreme1

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so what is the difference with the new one coming?
 

idunk42

King Kong
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The new one that is coming has the effects of the Ghrp-6 without the ghrenlin effects (appetite enhancer -hexa and appetite depresser - ecto)
 

diamonddave

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Well damn! I was thinking this was going to be the [D-Lys 3] version. That's the one that is the ghrelin antagonist and suppresses appetite.
The last thing I need is an appetite amplifier. I think they used to carry the D-Lys peptide, so I thought they were just bringing it back by popular demand or something.
Do we know for sure that this will not be the antagonist?

dd
 
crewchief182

crewchief182

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Looking forward to getting hexatropin back again. Wasn't the hexarelin addition to GHRP-6 what made this such a superior product compared to just plain GHRP-6? What might this new booster to GHRP-6 be in the new hexatropin? Can't wait to see!!!
 

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