dsade
NutraPlanet Fanatic
Some light editing left, but i want to get this posted since we are already selling while final labels are being done.
VIRILE MANE SERUM 25 WRITEUP
In men, balding can negatively affect confidence, self-image, mental health, perception of overall health and age, as well as mate selection/appeal. In women, hair loss can be absolutely devastating on a scale that is hard to appreciate.
For hundreds of years now, scientists and quacks have promised that the solution is either here or just around the corner, usually choosing to focus on “that one magic bullet that will offer a cure”. As I’ve repeated so many times, there is no such thing. The body is a complex machine, and the hair follicles some of the most complex components of this complex machine. As small, almost micro, organs, the follicles are extrememely sensitive to even minute changes in the body. Microvasculature, glycogen storage and metabolism, Reactive Oxygen (and nitrogen) Species (Free Radicals), and lipid/hormone disruptions can cause these micro-organs to malfuction, leading to hair loss and failure to regrow new hairs. If you’re here now, then this is probably a dilemma you’re facing. Well, let’s get on it then…
This subject is very, very complex so I’ve done the best I can to simplify.
A study performed by Sadgrove, et al, in Cosmetics 2023 elucidate 8 key areas that control hair growth and follicle health.
https://www.mdpi.com/2079-9284/10/4/106
They are identified as (paraphrased and expanded):
1. Androgens – Androgen receptor overactivation, with subsequent interference with phase control
2. Prostaglandins – With a complex interplay depending on the type of prostaglandins formed, prostaglandins are generally proinflammatory but some types trigger a potent repair function that can rescue hair growth
3. Overactive Aerobic Metabolism of Glucose – dysregulation of glucose metabolism(metabolic syndrome, etc) can lead to malfunctions of follicular glycogen storage, which starves the follicle, as well as inflammation and vascular disorders leading to exacerbation of growth phase dysfunction and hair loss.
4. Bacterial or Fungal Over-colonization – which we find is slightly less important for garden-variets Androgenic Alopecia (male pattern baldness), but have addressed indirectly
5. Inflammation - which plays a huge and complex role, not only in follicular function, but whole body health
6. Fibrosis- affecting whole body tissues and one of the main culprits in so many health problems, including cardiovascular disease
7. Metabolism or Circulation Problems – meaning without adequate blood and nutrient supply, and the transport and elimination of waste products, the highly fragile follicles are crippled
8. Malnutrition - if you have delved this deeply to get you to this point, we would hope you understand the critical importance of proper macro and micro nutrition including balanced blood sugar levels, and intake of vitamins, minerals, and phytonutrients.
This is a good solid list, and a wonderful starting point – but things are even more complex. Energy states (AMPk and mTORc1 signaling), BMP initiation and inhibition of follicle growth phases including fibroblast growth factors, Adenosine triggers, Estrogenic and IGF-1 signals, and other enzymes, and a few others will be covered here.
Ingredients
Genistein-Nicotinamide Crystals
Estrogen Receptor Beta, a relatively recent discovery on the scene, functions as a balance to Estrogen Receptor Alpha receptor (which was once thought to be the only one.) Very slight ERa activation can help to trigger hair growth, but it’s a very touchy balance before it forces the follicle into catagen phase . Activation of the ERbeta receptor mediates estrogenic signaling, and has a potent effect on transition to Anagen phase.
https://pubmed.ncbi.nlm.nih.gov/15591132/
Genistein, an isoflavone contained in soy, has a high selectivity and potent activation of Estrogen Receptor Beta.
pubmed.ncbi.nlm.nih.gov
Erb and catagen blocking
https://pubmed.ncbi.nlm.nih.gov/15591132/
Nicotinamide- You will find that I have used Nicotinamide (an active form of vitamin B3) several times in my crystalline complexes. In addition to being an excellent and simple coformer, Nicotinamide has hair growth promoting effects on its own, notably reducing an enzyme called DKK-1, which triggers follicles to regress back to telogen/catagen phase. By reducing the activity of this enzyme, our Anagen phase can be amplified and prolonged. Nicotinamide also functions to scavenge free radicals.
pmc.ncbi.nlm.nih.gov
Puerarin-Ascorbic Acid Crystals
Puerarin is a high-quality isoflavone found in an invasive vine known as Kudzu. It functions as another Estrogen Receptor beta agonist, anti-oxidant, 5a-reductase inhibitor, and GSK-3b inhibitor/
https://pubmed.ncbi.nlm.nih.gov/22278629/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8061915/
Puerarin also maintains natural pigmentation in the new hairs, so the hairs that do grow in should match mature natural color.
https://www.mdpi.com/2079-9284/9/6/118
Puerarin also seems to be an effective inhibitor of the DPP4 enzyme, most known for breaking down GLP1, but also has significant effects in the hair follicle. Inhibition of this enzyme cause hasten entry into Anagen phase.
https://www.sciencedirect.com/science/article/pii/S0022202X23020730
Myricetin-Nicotinamide Crystals
While Myricetin is a wonderful compound, and I expect more research to occur regarding its role in hair growth, we are including it for more of a singular purpose.
GSK-3b, or Glycogen Synthase Kinase 3b, is yet another ubiquitous enzyme that very tightly controls growth processes. It limits reponses to GLP-1 and Adiponectin, blunts the body’s response to IGF-1, inhibits the body’s (and hair follicle’s) ability to properly store glycogen, contributes to mitochondrial dysfunction, inhibits muscle growth and adaptation to training and, as a major factor here, completely destabilizes out beloved WNT/b-catenin.
https://pubmed.ncbi.nlm.nih.gov/19238412/
Myricetin is an extremely potent GSK3b inhibitor, which will both boost the follicular sensitivity to IGF-1, correct mitochondrial function, aid in the proper glycogen balance to help feed the follicles, and stabilize WNT/b-catenin to prolonged Anagen.
applbiolchem.springeropen.com
Myricetin also restores functioning and response of Endothelial Nitric Oxide Synthase and NO for vascular dilation and increase of blood flow.
pubmed.ncbi.nlm.nih.gov
VIRILE MANE SERUM 25 WRITEUP
In men, balding can negatively affect confidence, self-image, mental health, perception of overall health and age, as well as mate selection/appeal. In women, hair loss can be absolutely devastating on a scale that is hard to appreciate.
For hundreds of years now, scientists and quacks have promised that the solution is either here or just around the corner, usually choosing to focus on “that one magic bullet that will offer a cure”. As I’ve repeated so many times, there is no such thing. The body is a complex machine, and the hair follicles some of the most complex components of this complex machine. As small, almost micro, organs, the follicles are extrememely sensitive to even minute changes in the body. Microvasculature, glycogen storage and metabolism, Reactive Oxygen (and nitrogen) Species (Free Radicals), and lipid/hormone disruptions can cause these micro-organs to malfuction, leading to hair loss and failure to regrow new hairs. If you’re here now, then this is probably a dilemma you’re facing. Well, let’s get on it then…
This subject is very, very complex so I’ve done the best I can to simplify.
A study performed by Sadgrove, et al, in Cosmetics 2023 elucidate 8 key areas that control hair growth and follicle health.
https://www.mdpi.com/2079-9284/10/4/106
They are identified as (paraphrased and expanded):
1. Androgens – Androgen receptor overactivation, with subsequent interference with phase control
2. Prostaglandins – With a complex interplay depending on the type of prostaglandins formed, prostaglandins are generally proinflammatory but some types trigger a potent repair function that can rescue hair growth
3. Overactive Aerobic Metabolism of Glucose – dysregulation of glucose metabolism(metabolic syndrome, etc) can lead to malfunctions of follicular glycogen storage, which starves the follicle, as well as inflammation and vascular disorders leading to exacerbation of growth phase dysfunction and hair loss.
4. Bacterial or Fungal Over-colonization – which we find is slightly less important for garden-variets Androgenic Alopecia (male pattern baldness), but have addressed indirectly
5. Inflammation - which plays a huge and complex role, not only in follicular function, but whole body health
6. Fibrosis- affecting whole body tissues and one of the main culprits in so many health problems, including cardiovascular disease
7. Metabolism or Circulation Problems – meaning without adequate blood and nutrient supply, and the transport and elimination of waste products, the highly fragile follicles are crippled
8. Malnutrition - if you have delved this deeply to get you to this point, we would hope you understand the critical importance of proper macro and micro nutrition including balanced blood sugar levels, and intake of vitamins, minerals, and phytonutrients.
This is a good solid list, and a wonderful starting point – but things are even more complex. Energy states (AMPk and mTORc1 signaling), BMP initiation and inhibition of follicle growth phases including fibroblast growth factors, Adenosine triggers, Estrogenic and IGF-1 signals, and other enzymes, and a few others will be covered here.
Ingredients
Genistein-Nicotinamide Crystals
Estrogen Receptor Beta, a relatively recent discovery on the scene, functions as a balance to Estrogen Receptor Alpha receptor (which was once thought to be the only one.) Very slight ERa activation can help to trigger hair growth, but it’s a very touchy balance before it forces the follicle into catagen phase . Activation of the ERbeta receptor mediates estrogenic signaling, and has a potent effect on transition to Anagen phase.
https://pubmed.ncbi.nlm.nih.gov/15591132/
Genistein, an isoflavone contained in soy, has a high selectivity and potent activation of Estrogen Receptor Beta.
Effect of genistein as a selective estrogen receptor beta agonist on the expression of Calbindin-D9k in the uterus of immature rats - PubMed
Genistein, a phytoestrogen possessing a high affinity for estrogen receptor beta (ERbeta), is of increasing interest because of its possible influence on the physiology of mammalian reproductive tracts. Although estrogen has been demonstrated to regulate Calbindin-D9k (CaBP-9k) in the rat uterus...
pubmed.ncbi.nlm.nih.gov
Erb and catagen blocking
https://pubmed.ncbi.nlm.nih.gov/15591132/
Nicotinamide- You will find that I have used Nicotinamide (an active form of vitamin B3) several times in my crystalline complexes. In addition to being an excellent and simple coformer, Nicotinamide has hair growth promoting effects on its own, notably reducing an enzyme called DKK-1, which triggers follicles to regress back to telogen/catagen phase. By reducing the activity of this enzyme, our Anagen phase can be amplified and prolonged. Nicotinamide also functions to scavenge free radicals.
Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells - PMC
An increasing number of people are suffering from hair loss disorders. Niacinamide has long been used as an active ingredient for anti-hair loss preparations but the exact mechanism has not been clearly elucidated yet. The effects of niacinamide ...
pmc.ncbi.nlm.nih.gov
Puerarin-Ascorbic Acid Crystals
Puerarin is a high-quality isoflavone found in an invasive vine known as Kudzu. It functions as another Estrogen Receptor beta agonist, anti-oxidant, 5a-reductase inhibitor, and GSK-3b inhibitor/
https://pubmed.ncbi.nlm.nih.gov/22278629/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8061915/
Puerarin also maintains natural pigmentation in the new hairs, so the hairs that do grow in should match mature natural color.
https://www.mdpi.com/2079-9284/9/6/118
Puerarin also seems to be an effective inhibitor of the DPP4 enzyme, most known for breaking down GLP1, but also has significant effects in the hair follicle. Inhibition of this enzyme cause hasten entry into Anagen phase.
https://www.sciencedirect.com/science/article/pii/S0022202X23020730
Myricetin-Nicotinamide Crystals
While Myricetin is a wonderful compound, and I expect more research to occur regarding its role in hair growth, we are including it for more of a singular purpose.
GSK-3b, or Glycogen Synthase Kinase 3b, is yet another ubiquitous enzyme that very tightly controls growth processes. It limits reponses to GLP-1 and Adiponectin, blunts the body’s response to IGF-1, inhibits the body’s (and hair follicle’s) ability to properly store glycogen, contributes to mitochondrial dysfunction, inhibits muscle growth and adaptation to training and, as a major factor here, completely destabilizes out beloved WNT/b-catenin.
https://pubmed.ncbi.nlm.nih.gov/19238412/
Myricetin is an extremely potent GSK3b inhibitor, which will both boost the follicular sensitivity to IGF-1, correct mitochondrial function, aid in the proper glycogen balance to help feed the follicles, and stabilize WNT/b-catenin to prolonged Anagen.
Flavones with inhibitory effects on glycogen synthase kinase 3β - Applied Biological Chemistry
Because glycogen synthase kinase-3 (GSK-3) activity is linked to various human diseases, it has been targeted in new drug development. Flavonoids, including luteolin, apigenin, and quercetin, inhibit GSK-3β; however, the relationships between their structural properties and inhibitory effects...
applbiolchem.springeropen.com
Myricetin also restores functioning and response of Endothelial Nitric Oxide Synthase and NO for vascular dilation and increase of blood flow.
Myricetin: A review of the most recent research - PubMed
Myricetin(MYR) is a flavonoid compound widely found in many natural plants including bayberry. So far, MYR has been proven to have multiple biological functions and it is a natural compound with promising research and development prospects. This review comprehensively retrieved and collected the...
pubmed.ncbi.nlm.nih.gov
