dsade
NutraPlanet Fanatic
The complexity of this subject matter is extremely high. To do it justice, the writeup should have been 20 pages - but alas we live in the real world where something has to be explained just enough so you will understand the important things. With that in mind, I apologize ahead of time if it seems to be a chaotic shotgun blast to the face, rather than a casual read.
Let's do a quick overview of what angles we will be covering with MyoSynergy.
IGF1--->AKT--->mTORc1 (arrow means a subsequent pathway is activated) - IGF-1 is an anabolic hormone released in response to workouts (notably mechanical stress). When it attaches to its receptor (IGF-1r) it triggers AKT (aka Protein Kinase B) which, in turn, activates mTORc1. Ultimately mTORc1 is the signal that causes a rapid increase in muscle protein synthesis and hypertrophy.
At the same time IGF-1--->AKT---|GSK3b (vertical line means that the pathway is blocked) causes inhibition of Glycogen Synthase Kinase 3b which prevents atrophic pathway from activating, thus preventing muscle breakdown.
Myostatin/TGFb1/SMAD2/3
Myostatin is the bad guy here. Myo meaning Muscle, statin meaning to stop or cause to be inactive, myostatin is a protein that prevents muscular adaptation to exercise (e.g. muscle growth). Myostatin activates members of the TGFb1 family, and eventually triggers activation of SMAD2/3 which then not only prevents muscle growth, but triggers muscle breakdown (atrophy).
BMP/SMAD1/5/8 Bone Morphogenetic Proteins are incredibly potent signal proteins that cause stem/satellite cell differentiation. By drawing on this pool of undifferentiated cells, they can be pushed to form new bone, connective, and muscle tissue resulting in rapid hypertrophy.
SMAD4 is an escort molecule. Both SMAD2/3 (atrophic) and SMAD 1/5/8 (hypertrophic) compete to join with SMAD4 to move to the nucleus and exert their effects. Inhibition of SMAD2/3 means that SMAD1/5/8 has unrestricted access to SMAD4 and the hypertrophic effects are greatly amplified.
Myosynergy stands as a new generation of products that will prevent muscle atrophy and amplify hypertrophy.
Here we go.
MYOSYNERGY ELITE WRITEUP
It’s a dream as old as man (and woman) itself. To have a body that is also a work of art. Lean, strong, capable, and aesthetically perfect. Even with all the nutritional and technological advantages that we have, for most that dream remains out of reach. Stress, time restraints, temptations, and an uncooperative body “designed” to keep our physique restrained by mediocrity all contribute to place our dreams out of reach. No more.
MyoSynergy Elite is a brand new formula expanding on the success of the original MyoSynergy formula, with some extremely exciting developments. Like the original formula, MyoSynergy Elite has been designed to potently trigger multiple pathways of muscle building at the cellular level and maximize training results.
Muscle. One step forward, one step back. No matter how hard we train, or how many chicken breasts we choke down, it seems that progress is slow – even stagnant at time. Muscle is expensive. From the perspective of nature, muscle is expensive. It is expensive to grow, expensive to maintain, and is kept tightly controlled by multiple metabolic pathways.
To better understand what’s going on here, it is important to have a little bit of background on the ways the body upregulates (increases) muscle growth (muscle protein synthesis). We don't just grow or shrink unless we have the proper signals to do so. It is also important to understand the way the body also downregulates (decreases) muscle mass.
As hybrid hunter-gatherers, humans have relied on the hunting of meat since time began. Lacking huge fangs or claws or overwhelming mass, humans have developed their intellect and teamwork/cooperation to outsmart our prey. We still, however, require a degree of strength and swiftness to finish the hunt. Our bodies are, hypothetically speaking, blind. We perceive the world through electrochemical means (e.g. sounds stimulate electical waves). So how does our body know that we have been successful in a hunt, and that it needs to not only repair itself, but build additional muscle in order to become more efficient for next time?
Humans, and other animals, sense the intake of nutrients as the main indicator that our hunt has been successful. The body “recognizes” certain components of protein, called Amino Acids, that represent meat intake and activates mTOR (mammalian Target of Rapamycin). Considered the master trigger of protein synthesis in muscle, mTOR is the key player in this cascade. MTOR can ba activated via several ways – primarily dietary intake. Notably the branched-chain amino acid Leucine, but also other amino acids. As well, after a successful hunt, the subsequent gorging also involves a significant intake of fat which surrounds the meat. The body uses something called Bile to help digest the ingested fat. Interestingly, bile receptors (TGR5) also activate mTOR and trigger muscle healing and growth. Now think about that. Successful hunt, which is insanely demanding on the body requiring 100% effort, results in prey being killed. Hunger signals then motivate the hunter to devour the kill. Meat, blood, fatty tissue – all consumed in an orgy as old as life itself. That rush of nutrients is a reward, but also the investment into the next hunt, by telling the body to make itself stronger, faster, and more efficient at hunting. (see mTOR section below.)
That’s great...but HOW does it know?
As we discussed, the body is “blind”. Each and every step must be individually activated, and each nutrient sensor does its part resulting in a chemical cascade, one step activating the next and the next.
So let’s break down some of the key concepts that are important to understand
Let's do a quick overview of what angles we will be covering with MyoSynergy.
IGF1--->AKT--->mTORc1 (arrow means a subsequent pathway is activated) - IGF-1 is an anabolic hormone released in response to workouts (notably mechanical stress). When it attaches to its receptor (IGF-1r) it triggers AKT (aka Protein Kinase B) which, in turn, activates mTORc1. Ultimately mTORc1 is the signal that causes a rapid increase in muscle protein synthesis and hypertrophy.
At the same time IGF-1--->AKT---|GSK3b (vertical line means that the pathway is blocked) causes inhibition of Glycogen Synthase Kinase 3b which prevents atrophic pathway from activating, thus preventing muscle breakdown.
Myostatin/TGFb1/SMAD2/3
Myostatin is the bad guy here. Myo meaning Muscle, statin meaning to stop or cause to be inactive, myostatin is a protein that prevents muscular adaptation to exercise (e.g. muscle growth). Myostatin activates members of the TGFb1 family, and eventually triggers activation of SMAD2/3 which then not only prevents muscle growth, but triggers muscle breakdown (atrophy).
BMP/SMAD1/5/8 Bone Morphogenetic Proteins are incredibly potent signal proteins that cause stem/satellite cell differentiation. By drawing on this pool of undifferentiated cells, they can be pushed to form new bone, connective, and muscle tissue resulting in rapid hypertrophy.
SMAD4 is an escort molecule. Both SMAD2/3 (atrophic) and SMAD 1/5/8 (hypertrophic) compete to join with SMAD4 to move to the nucleus and exert their effects. Inhibition of SMAD2/3 means that SMAD1/5/8 has unrestricted access to SMAD4 and the hypertrophic effects are greatly amplified.
Myosynergy stands as a new generation of products that will prevent muscle atrophy and amplify hypertrophy.
Here we go.
MYOSYNERGY ELITE WRITEUP
It’s a dream as old as man (and woman) itself. To have a body that is also a work of art. Lean, strong, capable, and aesthetically perfect. Even with all the nutritional and technological advantages that we have, for most that dream remains out of reach. Stress, time restraints, temptations, and an uncooperative body “designed” to keep our physique restrained by mediocrity all contribute to place our dreams out of reach. No more.
MyoSynergy Elite is a brand new formula expanding on the success of the original MyoSynergy formula, with some extremely exciting developments. Like the original formula, MyoSynergy Elite has been designed to potently trigger multiple pathways of muscle building at the cellular level and maximize training results.
Muscle. One step forward, one step back. No matter how hard we train, or how many chicken breasts we choke down, it seems that progress is slow – even stagnant at time. Muscle is expensive. From the perspective of nature, muscle is expensive. It is expensive to grow, expensive to maintain, and is kept tightly controlled by multiple metabolic pathways.
To better understand what’s going on here, it is important to have a little bit of background on the ways the body upregulates (increases) muscle growth (muscle protein synthesis). We don't just grow or shrink unless we have the proper signals to do so. It is also important to understand the way the body also downregulates (decreases) muscle mass.
As hybrid hunter-gatherers, humans have relied on the hunting of meat since time began. Lacking huge fangs or claws or overwhelming mass, humans have developed their intellect and teamwork/cooperation to outsmart our prey. We still, however, require a degree of strength and swiftness to finish the hunt. Our bodies are, hypothetically speaking, blind. We perceive the world through electrochemical means (e.g. sounds stimulate electical waves). So how does our body know that we have been successful in a hunt, and that it needs to not only repair itself, but build additional muscle in order to become more efficient for next time?
Humans, and other animals, sense the intake of nutrients as the main indicator that our hunt has been successful. The body “recognizes” certain components of protein, called Amino Acids, that represent meat intake and activates mTOR (mammalian Target of Rapamycin). Considered the master trigger of protein synthesis in muscle, mTOR is the key player in this cascade. MTOR can ba activated via several ways – primarily dietary intake. Notably the branched-chain amino acid Leucine, but also other amino acids. As well, after a successful hunt, the subsequent gorging also involves a significant intake of fat which surrounds the meat. The body uses something called Bile to help digest the ingested fat. Interestingly, bile receptors (TGR5) also activate mTOR and trigger muscle healing and growth. Now think about that. Successful hunt, which is insanely demanding on the body requiring 100% effort, results in prey being killed. Hunger signals then motivate the hunter to devour the kill. Meat, blood, fatty tissue – all consumed in an orgy as old as life itself. That rush of nutrients is a reward, but also the investment into the next hunt, by telling the body to make itself stronger, faster, and more efficient at hunting. (see mTOR section below.)
That’s great...but HOW does it know?
As we discussed, the body is “blind”. Each and every step must be individually activated, and each nutrient sensor does its part resulting in a chemical cascade, one step activating the next and the next.
So let’s break down some of the key concepts that are important to understand
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