Which nootropics/brain supplements have build up effects and get better with continuous daily usage?
I think this is a great, although maybe complicated topic. I’m on mobile so I’ll have to be brief (compared to my usual).Which nootropics/brain supplements have build up effects and get better with continuous daily usage?
Thank you for such an incredible response!I think this is a great, although maybe complicated topic. I’m on mobile so I’ll have to be brief (compared to my usual).
I think this is one of the reasons people miss out or think nootropics aren’t effective. Lots tend to be gradual and build long term effects, they aren’t just caffeine substitutes as far as effects.
It also helps to determine what benefits you may need or where you are deficient to find the best means of attack.
Not comprehensive, but things that help manage stress (both physical, mental, oxidative, etc), boost receptor activity in possibly deficient areas (may be dependent on the individual), improved mitochondrial health (and energy production) and things that help with neuron growth and repair (NGF and BDNF levels).
Particular “longer” term nootropics I like (again not fully comprehensive list):
Bacopa: actually adaptogenic and can be sedating or stimulating in some. Helps by reducing stress and anxiety, additional effects on memory and cognition, etc. Look for extracts high enough in Bacosides, with 300mg daily (50% Bacoside content) being shown beneficial.
Phospatidylserine: cell phospholipid, so in short all sorts of benefits with healthy cell membranes. Also, potentially ergogenic in regards to cortisol effects (particularly in regards to training), but at higher doses. 100mg daily is probably the minimum for brain health benefits, although 100mgx3 daily doses has shown ability to prevent cognitive decline too. Serinaid by Chemi Nutra is PS if familiar with that.
Lions Mane: boosts NGF (boosts memory and learning). This mushroom has tons of other benefits and I’m a huge fan for all it’s benefits. Needs decently high doses, I’d look for a minimum of 500mg and also mushroom quality is important so I wouldn’t just go with cheapest (just find a reputable brand not just cheapest option of random brand on amazon).
Neurofactor: increase BDNF. 100mg is typically recommended.
Again not comprehensive and these may provide immediate benefits, but tend to provide some long term benefits more so.
Ya I left them out since I feel you can notice them pretty acutely. Doesn’t mean they don’t have long term benefits more so that the ones I listed I feel people take and don’t immediately feel so they may discount.Thank you for such an incredible response!
I think choline donors are a worthy mention in here too, Alpha GPC, Congnizin etc. Also ALCAR, which is probably the most well known.
Luckily you don't need a standardized extract. Both of the most promising human studies on lion's mane have simply used 2-3 grams/day of powdered fruiting body. You can find powdered fruiting body if you look, although mycelium is more common. There's debate as to which is superior, and there's arguments in favor of both, but given that the studies used fruiting body, and showed it worked well, I'd replicate that as closely as possible.I am a fan of Lion's Mane, I'm especially interested in it's ability to increase BDNF from longer term use. However, finding a real standardized version is hard/rare to come by.
Yes, see my response regarding racetams and choline, but, that said, there is research showing that AChE-Is like huperzine and galantamine have pretty potent acute effects in terms of inhibiting AChE, so even if they would be ideal to use daily, they certainly have acute effects as well.Thank you for such an incredible response!
I think choline donors are a worthy mention in here too, Alpha GPC, Congnizin etc. Also ALCAR, which is probably the most well known.
2-3g of Lions Mane, damn. I only have 600mg of Lions Mane powder in my Brain Gainz. I guess I'll have to add some extraLuckily you don't need a standardized extract. Both of the most promising human studies on lion's mane have simply used 2-3 grams/day of powdered fruiting body. You can find powdered fruiting body if you look, although mycelium is more common. There's debate as to which is superior, and there's arguments in favor of both, but given that the studies used fruiting body, and showed it worked well, I'd replicate that as closely as possible.
As to the original question, lion's mane is a good one, as is bacopa, which takes a few/handful of weeks to really manifest benefits.
Yeah, lions mane is a hard one to find dosed properly in multi-ingredient products. In pills, it takes up multiple pills itself, and in powders, it doesn’t exactly taste good, and it’s not cheap either way.2-3g of Lions Mane, damn. I only have 600mg of Lions Mane powder in my Brain Gainz. I guess I'll have to add some extra
The blue rasperry flavouring in Brain Gainz is very strong, so hopefully it'll be able to mask the flavour of an extra gram or two of Lions Mane. Apart from the lower dose of Lions Mane it's a pretty well dosed product with a very good profile... Well from my knowledge anywayYeah, lions mane is a hard one to find dosed properly in multi-ingredient products. In pills, it takes up multiple pills itself, and in powders, it doesn’t exactly taste good, and it’s not cheap either way.
Ya that product is pretty stacked! I've seen it before and it looks great. The Black version looks solid too. At two scoops it is amazingly well dosed.The blue rasperry flavouring in Brain Gainz is very strong, so hopefully it'll be able to mask the flavour of an extra gram or two of Lions Mane. Apart from the lower dose of Lions Mane it's a pretty well dosed product with a very good profile... Well from my knowledge anyway
The caffeine free version that I have is really easy to drink and even at just a few weeks in has had some noticable effects.Ya that product is pretty stacked! I've seen it before and it looks great. The Black version looks solid too. At two scoops it is amazingly well dosed.
I'll note that I don't usually even take a whole 3g of Lions Mane a day, but have been using 2g recently and interested to see how that works longer term (I've used the 600mg found in quite a few products consistently).
I used Focus XT (Caffeine Free version) for a few months last year, I actually recommended it to a few people. Huperzine-A was a nice addition to that, it's very underrated in my opinion.Focus XT contains a lot of great nootropic ingredients, many of which have a great long term cumulative effect.
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