Blast from the past. I guess I should share my adventure with burdock root to save someone else the time and headaches. Attached is the long version. You can skip to the end for the current recipe.
Based upon the research paper, I wanted to reproduce the 600mg/kg mouse model dosage. Here comes the calculation. 600mg/kg x 90kg x 3/37(BSA conversion) / .12(extract yield)=~36000mg divide by 28350mg per ounce you get 1.5 ounces root per day. Now comes the preparation. From the paper it had the root cooked at 80degC for 1.5 hours. I took about 5-6 ounces of washed root in a blender with boiling water to make up 33fl ounces and blended it up. This quantity matched a juice bottle that I had on hand. Let it sit for an hour or two, took some and put the rest in the fridge for latter. I just eyeballed about 4 FL ounces two times a day. I strained it at first, but then stopped because the inulin fiber in the root is supposed to be good for you. Straining it had no real impact other than ease of drinking and I got tired of cleaning the strainer.
The first thing you find is one of the side effects becomes annoying. It is a mild diuretic and laxative. In this form it became a Major laxative. Long term it was not usable unless you were going to stay home. I stopped after 2 days and looked for options. I found on the web that salt or soy sauce should be used when cooking burdock root. So I tried added a teaspoon of salt. The mixture changed from a light brown to a slightly darker brown. The effect was worse. I tried a teaspoon of sodium bicarbonate (during the whole bicarb frenzy), it turned much darker. This is the point where I almost gave up. The next day I felt the need to check the toilet for seat belts, and wanted to yell FIRE IN THE HOLE as everything let fly. I let 2 weeks go by before giving it another try.
This time I went in the other direction. I added two table spoons of apple cider vinegar to the mix. It was not as dark as the plain root, and a little better with GI tract. But not quite ready for prime time yet. Next I tried adding lemon juice to the mix prior to blending (one whole mid-sized lemon). This time it looked tan just like the color for the root. The side effects were tolerable, so off to the races we go.
After the first week I felt great. My energy level was up with higher controlled aggression in the gym. During the second week I started to up the dosage. More is always better right? I was getting close to the higher dose in the lab papers, which was 3 ounces per day. The runs started coming back but I didn’t care, because I felt great. Then after 2 ½ weeks everything fell flat. No amount could get it back. At this point I was not sure if I took too much or it must be cycled 2 weeks on and one week off. It could be both. It could have an inverted U response just like Bulbine and the lab test with rats was terminated after two weeks. I ran it one more time for just two weeks and it went alright. Then some other new supps came out and I got busy with work, home and other things and never posted this info.
Based upon your interest, I wanted to try another batch with lemon without any heating, just room temperature water. I will get back with the results if anybody wants to hear them.
If you want to give it a try use 5oz washed root with juice from one lemon and enough water for around 32oz. This is enough for 3-4 days. Start slow and see how it treats you.