I’ve often thought of AMPK activation through supplementation as catabolic-inducing and negatively impacting mTOR, which should theoretically be negative for muscle growth. I understand these supplements are great for glucose metabolism, but I want to know whether they’re actually anabolic or catabolic / negative for protein synthesis and hypertrophy?
I’ve seen a few studies lately that found AMPK activating supplements have actually helped obese, diabetic and elderly patients GAIN more muscle mass and help attenuate the effects of sarcopenia. This just confused me a bit. Is it possible AMPK activation is beneficial for anabolism for some populations but negative for younger, healthier population?
Again, I’m not interested in the importance of AMPK activation for blood glucose reduction and fat loss. I’m looking for its direct impact on anabolism and muscle growth. Any insight to this would be awesome.
I’ve seen a few studies lately that found AMPK activating supplements have actually helped obese, diabetic and elderly patients GAIN more muscle mass and help attenuate the effects of sarcopenia. This just confused me a bit. Is it possible AMPK activation is beneficial for anabolism for some populations but negative for younger, healthier population?
Again, I’m not interested in the importance of AMPK activation for blood glucose reduction and fat loss. I’m looking for its direct impact on anabolism and muscle growth. Any insight to this would be awesome.