Yet another potential benefit of creatine is that of an essential immune support supplement via energy for antitumor immunity. While this is a mouse model, there’s no reason to think it does not apply to humans as the cellular mechanisms are essential the same:
“…our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell–based cancer immunotherapies.”
So what does that mean? T cells need large amounts of energy to fight cancer, and it’s known they can suffer what’s called T-cell exhaustion. They literally run out of energy while attempting to fight cancer. As creatine is an essential molecule in energy production for all cells, it also acts as “molecular battery,” wherein stored energy helps these essential immune cells from simply running out of steam to fight on. More data is needed to be sure, but as it has such a long list of known benefits, this may be yet one more. The data also suggests that creatine may improve outcomes for those with cancer being treated via T cell–based cancer immunotherapies. Amazingly, feeding mice the dose of creatine typical of what humans ingest, they demonstrated the mice then had ability to suppress both colon and skin cancer growth. Creatine is of course just one of several key ingredients in my Bomb Proof Coffee recipe and continues to demonstrate a wide range of potential benefits, much of which is discussed on this web site as i was one on of the very first people to write about the non athletic/performance benefits in the lay publications.
Creatine uptake regulates CD8 T cell antitumor immunity
T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell.
Using CrT knockout mice, we showed that creatine uptake deficiency severely impaired antitumor T cell immunity. Supplementing creatine to WT mice significantly suppressed tumor growth in multiple mouse tumor models, and the combination of creatine supplementation with a PD-1/PD-L1 blockade treatment showed synergistic tumor suppression efficacy.
We further demonstrated that creatine acts as a “molecular battery” conserving bioenergy to power T cell activities. Therefore, our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell–based cancer immunotherapies.
Full Paper HERE