If physically active people consume one and a half grams of a mixture of the amino acids phenylalanine, alanine and arginine on a daily basis, the amount of fat in their abdominal cavity significantly decreases. Researchers from the Japanese Meiji Corporation reported this in Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
The Japanese divided 194 slightly obese people aged 20-64 years, with a BMI between 25 and 30, into 2 groups. For 12 weeks, one group received 1500 milligrams of the amino acids phenylalanine, alanine and arginine (42:38:20) [A-mix] every day. Another group received a placebo.
Meii’s R&D-department, together with researchers from the University of Tsubuka, has been studying the effect of amino acid supplementation on fat oxidation for several years. VAAM, an abbreviation of Vespa Amino Acid Mixture, was a result of that research. According to Meiji studies, supplementation with three grams of VAAM per day would improve the results of weight loss attempts, and increase the endurance of athletes.
Recently Meiji’s research focus has shifted to the phenylalanine-alanine-arginine combination. Studies by Meiji suggest that the combi stimulates the release of hormones such as adrenaline and glucagon, and thereby stimulates fat oxidation. [Int J Sport Nutr Exerc Metab. 2016 Feb;26(1):46-54.][Biosci Biotechnol Biochem. 2017 Jul;81(7):1417-24.][Diabetes Metab Syndr Obes. 2017 Jul 6;10:297-309.]
Both groups, thanks to a little encouragement from the researchers, walked about 10,000 steps a day.
Both groups lost body weight and body fat, but that did not lead to a statistically significant decrease in weight or fat mass in any of the groups. Both groups lost visceral fat, and this decrease was significantly greater among the amino acid cocktail users.
“The combination of A-mix supplementation and physical activity promotion facilitated abdominal fat reduction in overweight adults”, the researchers summarize.
Diabetes Metab Syndr Obes. 2018 Feb 26;11:23-33.