[futurepilot]

Ketotifen is perhaps best known for its ability to inhibit the down regulation of beta receptors caused by drugs like clenbuterol and albuterol. Clenbuterol and its sister drug albuterol are typically cycled on and off because they desensitize the very receptors they act on to produce their fat mobilizing effect. Ketotifen used in conjunction with either would allow the use of these fat burning drugs for much longer periods. This is convenient if, for example, a person is wishes to do a T3 cycle for a month or six weeks and use albuterol to ehnance T3's fat burning. Adding ketotifen would allow that person to use the albuterol throughout the entire T3 cycle.

Ketotifen is also recognized for its ability to lower levels of the catabolic cytokine Tumor Necrosis Factor-alpha (TNF-alpha). It is used by people suffering from AIDS or cancer to prevent muscle wasting caused to a large extent by TNF-alpha. In one study involving AIDS patients, combining ketotifen and oxymetholone showed that 18 out of 22 patients gained an average of 11.4 pounds after treatment of an average of 3.9 weeks (1).

There is a large body of research showing TNF-alpha lowers both testosterone and IGF-1 levels quite significantly (2,3). What's relevant to bodybuilders and other athletes is that strenuous exercise elevates TNF-alpha levels (4).

TNF-alpha has also been implicated in insulin resistance, the condition in which muscle uptake of glucose is hindered. Ketotifen then could potentially improve insulin sensitivity in muscle. (R-ALA is so popular because it too improves insulin sensitivity.)

Besides blocking TNF-alpha, ketotifen is a potent appetite stimulant. This is an aded bonus for someone with a wasting condition, or someone on a bulking cycle. This almost certainly contributed in part to the weight gain cited in the study above. When cutting using clenbuterol or albuterol, this is obviously going to force one to exercise more will power when it comes to dieting.

Recent research has shown that hypogonadism (low testosterone) is also associated with elevated TNF-alpha (5). Testosterone replacement reduces these high levels of TNF-alpha. After a cycle of anabolic steroids, a person is essentially in a hypogonadal state, with elevated TNF-alpha. This could be a possible factor in the loss of muscle mass that is normally seen after a cycle. Adding ketotifen to a typical post cycle therapy (PCT) regimen would likely help stave off this loss of muscle until testosterone levels return to normal, or until beginning the next cycle.

[futurepilot]

Has anyone had any experience with using this in conjunction with either Clenbuterol or Albuterol.

[futurepilot]

I guess the theory of using this is the help keep the receptors receiving? if thats not using the word in the definition.

[futurepilot]

i dont really understand the medical jargon on this stuff in its clinical uses.

[Grazer]

helps me sleep some. i either use it or benedryl when i am on albuterol.

buddy of mine said it helped his clen work longer

i'm not a fan of clen, so dunno

[futurepilot]

Helping me sleep sounds like a good enough reason on its own.

You said your not a fan of clen, does that mean you think Albuterol works better? Have you tried both to compare?

Also in general what sort of weight loss, either pounds or BF% have you experience from either. Anything you got would be appreciated.

[justreading]

anecodotal but I think it really is legit at being anti-catabolic... I stopped it and then in 5 days I shed 6 pounds and it was definetly not fat...

Personally i stopped taking it because it messed up my sleep and kept me nervous and half awake all night BUT that may have been from extending efficacy of clen.

I may try it on its own before bed as an anti-catabolic

[futurepilot]

Originally Posted by justreading

I stopped it and then in 5 days I shed 6 pounds and it was definetly not fat...

Care to elaborate?

Im guessing that you were using a clen/keto combination? If so this means that you continued the clen minus the keto?

Was this during PCT? on cycle? or just on it's own?

[justreading]

Originally Posted by futurepilot

Care to elaborate?

Im guessing that you were using a clen/keto combination? If so this means that you continued the clen minus the keto?

Was this during PCT? on cycle? or just on it's own?

I was on clen/keto and then extra keto at night. I stopped it all but may want to continue keto at night alone because whn I stopped i dropped a lot of muscle it appears.

[futurepilot]

I wonder if thats a normal reaction or not. It would be interesting to know exactly what the cause was. To bad you werent doin blood work or anything.

Supposedly clen is a somewhat anabolic substance. Maybe you responded to it, then when you stopped you lost your muscle in much the same way a person would with a poorly run PCT after an AAS cycle?

I dont know it that makes sence chemically/physiologically or not but it seems plausible, maybe. Im goin to look into that, see if theres anything to a "pct" or the like for clen, maybe they do something for horses that normal clen profiles dont mention.

[futurepilot]

Originally Posted by CHAPS

I like Clen, and yes Trip myself and many others can take it before bed. Personally the best combo i've ever used was clen/ketotifen, i was sweating profusely, it was ridiculous. As for over the counter Recreate, Leviathan Reloaded and DCP are your best bets. Only thing i find with Clen is i don't like how some of my workouts are inhibited like leg day for example, squating on clen i'm soooo outta breathe it's unbelievable.

I stole this from another thread.

[jsp0882]

Originally Posted by futurepilot

I stole this from another thread.

albuterol will give u the greatest workouts of ur life. it actually makes me enjoy cardio

[futurepilot]

Enjoying cardio sounds good. I get that from Clen, it makes you want to do something, anything, just move around. Cardio is a good outlet for that.

You find Albuterol lasts longer? I can get almost 3wks before i feel clen starting to work less.

[jsp0882]

Originally Posted by futurepilot

Enjoying cardio sounds good. I get that from Clen, it makes you want to do something, anything, just move around. Cardio is a good outlet for that.

You find Albuterol lasts longer? I can get almost 3wks before i feel clen starting to work less.

albuterol should work longer because clen is normally taken for 2 weeks then take time off then go for another 2 weeks. albuterol can be taken for longer and with benedryl or keto it can be taken for up to 6 weeks. since the half life is much shorter u can take it for longer.