[futurepilot]

Clenbuterol is a widely used bronchodilator in many parts of the world. Clenbuterol is a very interesting and remarkable compound. Clenbuterol is not a steroid hormone but a beta-2-symphatomimetic. The drug is most often prepared in 20mcg tablets, but it is also available in syrup and injectable form. Clenbuterol belongs to a broad group of drugs knows as sympathomimetics. These drugs affect that sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors. There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number. Depending on the specific affinities of these agents for the various receptors, they can potentially be used in the treatment of conditions such as asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches and anaphylactic shock. The text Goodman and Gillman's The Pharmacological Basis of Therapeutics Edition does a good job of describing the diverse nature in which these drugs affect the body. Clenbuterol, above all, has a strong anticatabolic effect, which means it decreases the rate at which protein is reduced in the muscle cell, consequently causing an enlargement of muscle cells.

Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types:

(1) peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands;

(2) a peripheral inhibitory action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle;

(3) a cardiac excitatory action, responsible for in increase in heart rate and force of contraction;

(4) metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue;

(5) endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones;

(6) CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite; and

(7) presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as such as norepinephrine and acetylcholine.

The drug clenbuterol is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that this drug has little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol to reduce reversible airway obstruction (and effect of beta-2 stimulation) with much less cardiovascular side effects compared to nonselective beta agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance. Clenbuterol also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours. This makes steady blood levels easy to achieve, requiring only a single or twice daily dosing schedule at most. This of course makes it much easier for the patient to use, and may tie in to its high compliance rate. In spite that clenbuterol is available in a wide number of other countries however; this compound has never been approved for use in the United States. The fact that there are a number of similar, effective asthma medications already available in this country may have something to do with this, as a prospective drug firm would likely not find it a profitable enough product to warrant undergoing the expense of the FDA approval process. Regardless, foreign clenbuterol preparations are widely available on the U.S. black market.

HOW TO USE CLENBUTEROL: Numerous athletes use Clenbuterol after steroid treatment to balance the resulting catabolic phase and thus obtain maximum strength and muscle mass. A further aspect of Clenbuterol is its distinct fatburning effect. Clenbuterol burns fat without dieting because it increases the body temperature slightly, forcing the body to burn fat for this process. Due to the higher body temperature Clenbuterol magnifies the effect of anabolic/androgenic steroids taken simultaneously

CLENBUTEROL DOSAGE: Athletes usually take 100-140 mcg/day. For women 80-100 mcg/day are usually sufficient, It is important that the athlete begin by taking only one tablet on the first day and then increasing the dosage by one tablet each of the following days until the desired maximum dosage is reached. The compound is usually taken over a period of 8-10 weeks. Since Clenbuterol is not a hormone compound. It has no has no side effects typical of anabolic steroids. For this reason it is also liked by women.

Side Effects of CLENBUTEROL: Possible side effects of Clenbuterol include restlessness, palpitations, tremor (involuntary trembling of fingers), headache, increased perspiration, insomnia, possible muscle spasms, increased blood pressure, and nausea. Note that these side effects are of a temporary nature and usually subside after 8-10 days, despite continuation of the product.

Many competitors also find the fat burning effect of clenbuterol can be further enhanced by additional substances. When combined with thyroid hormones, specifically T3, the thermogenic effect can become extremely dramatic. This can be to a point that the athlete could shred exceptional amounts of extra fat during contest preparations, without a dramatic restriction in calories. Such a mix can be further used during a steroid cycle, eliciting a much harder look from the anabolics. These cutting agents can often greatly inhibit extra fat storage during the cycle, even when using strong aromatizing androgens. A clenbuterol/thyroid mix is also common when using growth hormone, further enhancing the thermogenic and anabolic effect of this therapy.

[futurepilot]

Heres what i know about Clen. The question is if i decided to dose it with T3, what is a "standard" T3 dose?

If I include T3 should I include an AAS to prevent muscle wasting?

[ManBeast]

standard dosing of t3 involves tapering up and tapering down since it will shut down your own natural production of t3. the tapering down is critical.

MB

[futurepilot]

Maybe the answer could be found in an old post? I read an off hand remark about losing muscle while on clen/t3 so i figured id ask. If anyone knows about an old post that might have the answer i can always read it for myself, no luck so far searching.

[Rhyno]

T-3 and muscle loss

[futurepilot]

I dont know how i didnt see this but its a beauty of write up.

[z06]

Originally Posted by futurepilot

Heres what i know about Clen. The question is if i decided to dose it with T3, what is a "standard" T3 dose?

If I include T3 should I include an AAS to prevent muscle wasting?

I've used both t3 and clen in the past. Here's my personal example of how I would run it without the use of AAS:

CLEN:
You must start at a low dose and taper up until you've found your "sweet spot" so to say. Mine for example is 120mcg, which i now can just run without tapering up since I know my body can handle and react to it in a proper and safe manner. I'd start at 40mcg/day and increase by 20mcg every 3 days. If you get to a dose that is simply too much for you to handle lower the dose and maintain it there for the remainder of the cycle. Clen should also be run on a 2 week on, 2 week off basis since after prolonged use it become ineffective since it burns out your beta-2 receptors. A good way to keep these receptors fresh is by taking Benadryl at night before sleep.

T3:
A very catabolic agent that can cause significant muscle loss if used in too high of a dose. I found this out the hard way and ran 100mcg/day for 3 weeks and noticed its glycogen depleting properties as well as its catabolic effects. Once again you must play it safe so you don't permanently screw up your natural t3 levels which could lead to poor thyroid values. Start your dosing low at lets say 25mcg and increase it every 5-7 days until you've come to your proposed dose. Then it is vital to taper back down to ensure your natural t3 levels go back to normal. A diet of high protein is recommended and I would never take t3 any other way since it increases your metabolism.

HOW TO RUN A 6 WEEK CYCLE OF CLEN & T3 THE SMART WAY:

wk1 T3 @ 25mcg/day
wk2-5 T3 @ 50mcg/day
wk6 T3 @ 25mcg/day

wk1-2 Clen @ 40mcg-120mcg (tapering up)
wk3-4 OFF
wk5-6 Clen @ 120mcg/day (or your limit from experimenting the first 2 weeks, as you no longer need to taper up)

***Diet should be strict and high in protein as weight loss always comes down to diet & cardio. If you play by the rules the weight will drop.***

[futurepilot]

Solid advice. Much appreciated.