[SprtNvolcoM]

http://www.greatvistachemicals.com/h...forskolin.html

Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) is the main active ingredient in the Ayurvedic herb Coleus forskohlii. Coleus is a member of the mint family and grows in subtropical areas in India, Burma, and Thialand. Forskolin has been extensively researched in the medical field for use in the treatment of allergies, respiratory problems, cardiovascular diseases, glaucoma, and many other conditions. It has also recently gained popularity as a fat loss agent.


Forskolin is an extract of an Ayurvedic herb that resensitizes cell receptors by activating the enzyme adenylcyclase and increasing the levels of cyclic AMP in cells. Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones, including thyroid, HGH, Cortisol, DHEA, Testosterone, and Melatonin.

Forskolin appears to bypass this need for direct hormonal activation of adenylate cyclase via transmembrane activation. As a result of this activation of adenylate cyclase intracellular cAMP levels rise. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation and degranulation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; and increased lipolysis (fat destruction). Recent studies have found forskolin to possess additional mechanisms of action independent of its ability to directly stimulate adenylate cyclase and cAMP dependent physiological responses. Specifically forskolin has been shown to inhibit a number of membrane transport proteins and channel proteins through a mechanism that does not involve the production of cAMP. The result is again a transmembrane signaling that results in activation of other cellular enzymes.

Forskolin causes the arteries to relax. Because this can lower blood pressure, forskolin should not be used in tandem with blood pressure-lowering medications. Forskolin relaxes the bronchial muscles and may dangerously increase the potency or action of certain asthma drugs, including albuterol, theophylline, and beclomethasone. The basic mechanism of action of forskolin is the activation of an enzyme, adenylate cyclase, which increases cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP is perhaps the most important cell-regulating compound. Once formed it activates many other enzymes involved in diverse cellular functions. Under normal situations cAMP is formed when a stimulatory hormone (e.g., epinephrine) binds to a receptor site on the cell membrane and stimulates the activation of adenylate cyclase. This enzyme is incorporated into all cellular membranes and only the specificity of the receptor determines which hormone will activate it in a particular cell. Forskolin appears to bypass this need for direct hormonal activation of adenylate cyclase via transmembrane activation. As a result of this activation of adenylate cyclase intracellular cAMP levels rise. The physiological and biochemical effects of a raised intracellular cAMP level include: inhibition of platelet activation and degranulation; inhibition of mast cell degranulation and histamine release; increased force of contraction of heart muscle; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; and increased lipolysis. Recent studies have found forskolin to possess additional mechanisms of action independent of its ability to directly stimulate adenylate cyclase and cAMP dependent physiological responses. Specifically forskolin has been shown to inhibit a number of membrane transport proteins and channel proteins through a mechanism that does not involve the production of cAMP. The result is again a transmembrane signaling that results in activation of other cellular enzymes. Research is underway in the attempt to determine the exact receptors to which the forskolin is binding. Another action of forskolin is on antagonizing the action of platelet-activating factor (PAF) by interfering with PAF binding to receptor sites. PAF plays a central role in many inflammatory and allergic processes including neutrophil activation, increasing vascular permeability, smooth muscles contraction including bronchoconstriction, and reduction in coronary blood flow.

I'm also looking into cAMP itself, which is available online at certain supp sites. http://www.synergymuscle.com/catalog...products_id=35

USPlabs has ventured into a territory no other supplement company could imagine. Our innovative research teams developed cAMPHIBOLIC, which is the first non-stimulant based thermogenic that’s actually WORKS! Beyond cAMPHIBOLIC's thermogenic properties, cAMPHIBOLIC was the first product to halt muscle catabolism that occurs during dieting.

USPlabs has tweaked the cAMPHIBOLIC formula into the first NightTime Thermobolic. Yes, A product that will trick the body into using fat for fuel instead of glycogen and protein while increasing thermogenisis at NIGHT! cAMPHIBOLIC will shift the ratio of fat to carbohydrate for use as fuel towards fat burning. This helps preserve glycogen and skeletal muscle, which would otherwise be relied upon more heavily for fuel without cAMPHIBOLIC. By mobilizing fat, will make even more fat available as a fuel source, sparing more glycogen and muscle. The thyroid stimulating effect will further elevate RMR, leading to greater fat burning. By Blocking cortisol will help to preserve muscle tissue as well. An anabolic effect due to increased release of gonadotropins, as well as up regulation cholesterol transport into the testes, where it is converted to testosterone. Finally, a benzodiazepine-like anxiolytic effect that will doubtless promote sleep.

Interesting ... what do ou guys think about this liturature i found on forskolin & this particlar cAMP product (up above)???

I have actually found a company in germany that distributes cAMP in raw form ... I think its actually the "real" deal, and not just some mix of extracts found in USPlabs product. Check it:

The second messenger cyclic AMP activates the holo enzyme complex of the cAMP dependent protein kinase PKA, the Rap1 guanine-nucleotide-exchange factor Epac, cAMP-gated ion channels, CAP protein and some other target receptors. It is metabolized rapidly by cyclic nucleotide-dependent phosphodiesterases. Sodium salt. Molecular weight 351.2 g/mol. Appearance: White solid. Solubility: soluble in water. Purity: >99% (HPLC). Formula C10H11N5O6P . Na.

Product name: cAMP, sodium salt

Adenosine- 3', 5'- cyclic monophosphate (cyclic AMP), sodium salt





Order number / sizes:

order-no. PKE-CAMP-500: 500 µmol (~176 mg)
60,- EUR

I'm not to keen on the german symbols and such, maybe someone can help explain them. What do you all thik of this and the pricing?? They also sell in bulk. Is this cAMP any different the the previous cAMP by USPlabs I posted just above. I'm comparing the ingredients and I see no similarities.

Thanks,
Sprt

[diminuendo]

cyclic adenosine monophosphate and USPLabs camphibolic are not the same thing, though camphibolic is supposed to exert its effects through the manipulation of cAMP.

[Schwaugher]

Your research was a good read, but I haven't got a damn clue what would happen if you were to put pure cAMP into your body, that decision is completely up to you. Would you like to be the guinea pig?

[SprtNvolcoM]

Originally Posted by Schwaugher

Would you like to be the guinea pig?

YES!!!

lol, now more seriously ... what do you guy think about USPlabs cAMP or camphobics product? I had already made plans on purchasing this item but had not run it by a review yet. As anyone used it? I'd like to try it.

Also, the same german company sells forskolin in bulk as well. Would anyone, as schwauger put it, put that in your body or use it (not like a guinea pig)? It is in Liposolv and many other products. What would be the difference in supplimenting it straight? BBing.com sales this extract for like 8.99. I'm thinking of ordering a bottle for shits and giggles and through it into my mix of goodies. Ya or Na?

Thanks,
Sprt

[unitas27]

I am about to finish my bottle of USP Labs Camphibolic, honestly I didn't notice much from it, but it did seem to harden me up a little. Nutraplanet is having a blowout sale on USP Labs products right now. If I had a choice between Camphibolic or straight Forskolin, I would def choose Camphibolic.

[SprtNvolcoM]

Originally Posted by unitas27

I am about to finish my bottle of USP Labs Camphibolic, honestly I didn't notice much from it, but it did seem to harden me up a little. Nutraplanet is having a blowout sale on USP Labs products right now. If I had a choice between Camphibolic or straight Forskolin, I would def choose Camphibolic.

You just said that camphibolic produced no noticable changes other than hardness. Its suppusd to be thermobolic and work even in your sleep. In that case, i think Melting point and Forskolin would be a better option. Dont you?

On top of that, I can buy Green Tea Extract 200mg per capsule 95% Polyphenols for dirt cheap; which seems to be camphibolics main ingredient.

[SprtNvolcoM]

After comparing the before and after side by side, I do notice a difference; even if only slightly. I think the measurements are more note worthy. I still need a lot of work though. Looking back, I don't even remember noticing myself get this out of control. I would appreciate all the constructive criticisms you guys can give; it will help keep my on the right track and point me to focus more on the problems you see rather than the total overall appearance. Right now, if you asked me, I would say my number one concern is my lower abdominal and side (hip) love handles. I must stay the course. I know I still have a loooooong way to go, but I'm prepared and have all the necessary arsenal to get the job done. There is no deadline in my goals, but will definitely meet my goals sooner or later. Here are the pictures I promised. Enjoy.

Before:
Weight: 192.8lbs
Wasit: 37.5 inches



After:
Weight: 179.2lbs
Wasit: 34.75 inches



Total Loses to date:
Weight: 13.6lbs
Wasit: 2.75 inches

I'm extremely happy with the weight and waist measurments. They exceeded my previous expectations.

Thanks,
Sprt

PS: You should be able to click on the pictures to enlarge and veiw them better.

[unitas27]

I can def. notice the difference in the lower abs. Nice results so far! Sprt you have mail.

[SprtNvolcoM]

Date: 02/28/06, Tuesday (Day 23 -- 6 days post DNP)

Starting Weight: 192.8lbs (Morning Weigh)
Current Weight: 179.2lbs (Morning Weigh)
Total Loss 13.6lbs!!! (jumping around in weight a bit)
BF% Unknown (15%-ish @ start - you tell me?)

Suppliments:
- Multi Vitamin
- Vitamin B12
- Vitamin E
- Vitamin C
- Cranberry
- Garlic
- Fish Oil
- Selenium
- Chromium
- Pyruvate
- CLA

Diet:
Diet went very well today, but I am lacking in the water department. I also had a pepsi. Other than that, I havent eaten out side my previously planned meal plan. I thought I was going to have a cook off today and cook some new plates, but I decided to wait until tomorrow.

Training:
Workouts are so much better off DNP. Its like night and day; literally. Tonights workout went great. I'm back to all my previous loads. I'm not back to previous volume or intensity though. I've also switched from a full body HST type workout to a 3 day split. Before the cycle I was doing a 2on/1off/2on/2off upper/lower (low volume, high frequency) split; which worked out pretty good. Now, however, I'm doing a more traditional Back/Bi, Chest/Tri, Legs/Shoulder routine ... abs every other day (3x a week at least).

Personal Note:
I woke up this morning not thinking to much about my weight. I have been off DNP and any sort of dermals for 6 days today; well I started my dermals again tonight. I got on the scale and thought "that cant be right." I weighed a second time and sure enough ... 179.2lbs. That's down from 182.8lbs the day before. WTF?? I did cut carbs yesturday and I have been shitting alot ... lol ... but I wouldnt think it would leave me nearly 3lbs lighter. We'll see what the scale says tomorrow.

Thanks you to those who responded to my before and after. I'm still a fat bastard, but 13lbs down in 23 days (6 of which were drug free). I hope this second cycle (starting next monday) yields similar results. Even if I lose another 10lbs, I'll still see myself as a fatty. Maybe you guys can relate ... I havent had a 6pak in 6yrs, but when I did I still thought I was fat (I am a former fat kid, which is probably why this happens). Below 10% and I still thought I looked fat. lol, its weird how the mind works. I remember seeing a picture of someone on spring break that year. Who ever took the picture sucked ass because they cut the head of who ever was in the picture. When I saw it, i was like "damn ... who is that ripped mother @#$%!?" The motha @#$%! was me!! I was blown away.

Anyhow ... looking forward to trying out some new products. We have breifly discussed some of them. Liposolv, raw forskolin, camphibolics, Clen, Albuterol, ect. Well, I got to thinking ... what about the good old fashion E/C/A's during my off weeks?? I have a at work on the stuff and he's lost 11lbs.

Here is a few links:
http://www.fixfitness.com/index.asp?...&ProdID=7&HS=1
http://www.fixfitness.com/index.asp?...ProdID=45&HS=1
http://www.fixfitness.com/index.asp?...ProdID=60&HS=1

What do you guys think about any of those?? I can find C & A anywhere else pretty easily. The E is what concerns me. Any of these the old E we used back int he day?

That's all for now?
Sprt

[SprtNvolcoM]

Date: 02/29/06, Wednesday (Day 24 -- 7 days post DNP)

Starting Weight: 192.8lbs (Morning Weigh)
Current Weight: 178.6lbs (Morning Weigh)
Total Loss 14.2lbs!!! (a steady drop, once again)
BF% Unknown (15%-ish @ start - you tell me?)

Suppliments:
- Multi Vitamin
- Vitamin B12
- Vitamin E
- Vitamin C
- Cranberry
- Garlic
- Fish Oil
- Selenium
- Chromium
- Pyruvate
- CLA

Personal Note:
Blue higjhlights I believe are a huge contributer to my continuious drop in weight these last 7 dayd off DNP. That, and have been slight cal deficient the last 3 to 4 days along with minimzing carb intake in the pm hours. WO's and cardo sessions have not really change much other then they are returning to nromal statue in terms of previous loads, volume, & intsity (although the latter two more slowly than other factors). That being said, I am still not up the frequency i was once in the gym, yet continue to drop the weight. So what I am going, it seesm to be working.

I think since I have been taking this since my last cycle od DNP this next cycle should go twice as well. I've alwasy heard that your second bout with DNP is better anyhow. We'll see soon enough.

That's all for now?
Sprt

[SprtNvolcoM]

Say I wantd to try a different dermal in the future. From your experiences, which is better ...

[unitas27]

Skulpt smells like soy sauce, and it stains clothes. Liposolv does not, and the ingredients in liposolv are superior (so says Patrick Arnold).

[SprtNvolcoM]

Originally Posted by unitas27

Skulpt smells like soy sauce, and it stains clothes. Liposolv does not, and the ingredients in liposolv are superior (so says Patrick Arnold).

So Skult smells and stains the clothes, and liposolv cuaes kidney pains. lol. I think that I'm going to so is stick with what has worked for me; that being lipoderm-ultra & lipoder-ultra with the addition of clen.

To kick it up a knotch, I plan on using 70% ISOA with 10% DMSO added to it in a spray bottle, which will be used as an after spray several minutes after the Cap-HP and Lipoderm-U or Lipoderm/Clen mixture has been applied. That is basically all Liposolv and skulpt are anyway ... with the acception of forskolin, which I have ordered 60g (20% forskolin or forskihlii root extrack) to be capped and eaten immediatly upon recieving.

lol, f*ck all this dermal mess. Stick to what you know works and if necessary, add to it. I have two bottles of lipoderm ... no need to have more dermals; especially if they stain clothes and hurt kidneys.

Just my .2 cents,
Sprt

[unitas27]

The DMSO should be applied before the lipoderm. DMSO will suck all off lipoderms ingredients right into the subq layer with a quickness.

[SprtNvolcoM]

Originally Posted by unitas27

The DMSO should be applied before the lipoderm. DMSO will suck all off lipoderms ingredients right into the subq layer with a quickness.

isnt that what we want? plus, its only DMSO at or just under 10% the total mixture ... the rest of the after spray will be 90% 70% ISOA (rubbing alcohol). That will should limit the DMSO's dermal intensity enough to allow all the ingredients to inter the dermis and hit the adipose tissue.

Or am I way off??

Liposolve and Skulpt carrier is DMSO. So whats the difference. I just plan on using this as an after spray say 30min after I apply the CAP-HP and Lipoderm.