Cardarine /GW 501516

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  1. Quote Originally Posted by lokedog View Post
    Its how its mechanism of action, according to the abstracts , dictate it would cause you to plow through your fat stores like a fat chic through cake. I guess real world states otherwise. Good to know because energy is not an issue as far as working out.. im balls to the wall and get more work done in an hr than most i see taking 2 hrs.
    And if i can't be done in an hr n 20-30 minutes, it means I'm not working that hard. Im completely over the gym by then and the last thing i wanna do is even spend 5 more minutes there.. looks like cardarine is not for me.
    It's more for hard cardio mate you can just keep going and going past where you'd normally collapse with exhaustion. IME it doesn't help you with workouts it would just be a waste of money if you were using it for that.


  2. Oh and na it doesn't do anything for fat loss just lets you do longer cardio sessions which doesn't really mean **** all cos ya could just eat 50 less calories that day and save the money you'd spend on expensive pills.
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  3. About improving cardio one thing that scares me about this compound is the pounding your heart will take from having to oxygenate so much blood. I understand this may make you have better endurance but what about heart health?

  4. Quote Originally Posted by JCR97 View Post
    About improving cardio one thing that scares me about this compound is the pounding your heart will take from having to oxygenate so much blood. I understand this may make you have better endurance but what about heart health?
    Currently on gw, and I've been having so weird heart feelings. Like it feels heavy
  5. Cardarine /GW 501516


    Quote Originally Posted by Ihatbanas View Post
    Currently on gw, and I've been having so weird heart feelings. Like it feels heavy
    Don't mean to scare you bro. I actually ordered GW for myself and I'm scared because of this. Although I found a bit of info:

    GW 501516 prevents oxidative damage in the heart (R).
    It decreases the risk and severity of atherosclerosis (plaque buildup in the arteries) through a number of mechanisms. GW 501516 increased levels of nitric oxide, which protects against atherosclerosis (R).
    It also reduces lesions and inflammation associated with atherosclerosis in mice (R).
    GW 501516 increases VEGF production from human blood vessel cells, which triggers cell and blood vessel formation (R).
    GW 501516 results in an increase of HDL cholesterol and a decrease in triglycerides in animal studies, potentially decreasing the risk of cardiovascular disease in patients (R).
    https://selfhacked.com/blog/gw501516...fits_the_Heart


    Usually a heavy heart means you're not getting enough oxygen to the coronary arteries or you are getting fluid buildup in your pericardium which is extremely rare. Which by reading this I'm not too sure what to make of it. But hypertrophy of the heart could be possible.
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  6. So I can tell you that the "feeling of a heavy heart" has absolutely no correlation or indication that you have cardiac hypertrophy. Evidence of this would be a laterally displace PMI, some changes heard on auscultation, and imaging can also show evidence for cardiomegaly. But having the feeling of a heavy heart is as helpful as saying that you feel feverish without taking your temperature...and you end up not having a fever. If you feel that your heart is heavy that is prob just from being tired/exhausted and you just need to rest. However, unchecked hypertension, diabetes, prolonged AAS use (talking decades), and smoking are a few factors that can lead to cardiac hypertrophy, but I would have no worries of that being the case while running GW

  7. I recently got a bottle of GW with the thought that it may offset the low endurance/lethargy of doing a short course of an oral methylated anabolic.. or offset fatigue from tren use.. It could be very helpful in that regard if it indeed does improve endurance capacity.. Thoughts on this anyone?

  8. Quote Originally Posted by JCR97 View Post
    Don't mean to scare you bro. I actually ordered GW for myself and I'm scared because of this. Although I found a bit of info:

    GW 501516 prevents oxidative damage in the heart (R).
    It decreases the risk and severity of atherosclerosis (plaque buildup in the arteries) through a number of mechanisms. GW 501516 increased levels of nitric oxide, which protects against atherosclerosis (R).
    It also reduces lesions and inflammation associated with atherosclerosis in mice (R).
    GW 501516 increases VEGF production from human blood vessel cells, which triggers cell and blood vessel formation (R).
    GW 501516 results in an increase of HDL cholesterol and a decrease in triglycerides in animal studies, potentially decreasing the risk of cardiovascular disease in patients (R).
    https://selfhacked.com/blog/gw501516...fits_the_Heart


    Usually a heavy heart means you're not getting enough oxygen to the coronary arteries or you are getting fluid buildup in your pericardium which is extremely rare. Which by reading this I'm not too sure what to make of it. But hypertrophy of the heart could be possible.
    would be amazing if it could increase my hdl. my ldl is always low in the 110s but the hdl is also low never making it over 30ish. Its a familial thing. Both my parents are the same way. Nothing has made it go up and using anabolics lowers it to the mid 20s usually. But like I said even before I cycled my hdl was always low..

  9. Quote Originally Posted by Ihatbanas View Post
    Currently on gw, and I've been having so weird heart feelings. Like it feels heavy
    Does the product you take have any other compounds included? I know some include low doses of thyroid hormone analogs. and if this is the case, it could be the cause of your symptoms.

  10. Quote Originally Posted by bigdavid View Post
    I recently got a bottle of GW with the thought that it may offset the low endurance/lethargy of doing a short course of an oral methylated anabolic.. or offset fatigue from tren use.. It could be very helpful in that regard if it indeed does improve endurance capacity.. Thoughts on this anyone?
    I have heard things about scar tissue being built up while on GW. Not sure about it tho. Here's the link. the truth on cardarine

  11. So I don't know if I'm brakikng any rules but I got gw from Olympus uk, but I really don't feel any extra ordinary with it, I was doing 21mg a day but I went back to 14mg, but I haven't really feel anything than a pre workout wouldn't do.

  12. Quote Originally Posted by Ihatbanas View Post
    So I don't know if I'm brakikng any rules but I got gw from Olympus uk, but I really don't feel any extra ordinary with it, I was doing 21mg a day but I went back to 14mg, but I haven't really feel anything than a pre workout wouldn't do.
    How long have you been on it?

  13. Quote Originally Posted by Ihatbanas View Post
    So I don't know if I'm brakikng any rules but I got gw from Olympus uk, but I really don't feel any extra ordinary with it, I was doing 21mg a day but I went back to 14mg, but I haven't really feel anything than a pre workout wouldn't do.
    Well the fact that you are comparing it to a preworkout product tells me that it is indeed working!

  14. Seems like some people think it's going to kick in like DMAA, well it will not.
    Take it for a couple of days and then stand on a treadmill and you will at first see that you can easily last a lot longer without getting as tired as you would be without it.
    It will not motivate you to do cardio (give you that stim feel) but once you do it it will be a lot easier.
    No magic pill out there, only hard work and supplements that help you do it.

  15. Quote Originally Posted by xo0ox View Post
    Seems like some people think it's going to kick in like DMAA, well it will not.
    Take it for a couple of days and then stand on a treadmill and you will at first see that you can easily last a lot longer without getting as tired as you would be without it.
    It will not motivate you to do cardio (give you that stim feel) but once you do it it will be a lot easier.
    No magic pill out there, only hard work and supplements that help you do it.
    That's the thing I already do lots of cardio, and I don't feel that extra push..

  16. If your cardio is already decent then cardarine is not going to make you feel like superman.

    It's more subtle than that. Aside from time trials, I found that once I really started pushing myself, my leg muscles were giving out before my lungs while I was on the stuff.

  17. Proper amateur question here: would taking a large(ish) (still safe, of course) dose of 4-andro late in a cycle help with lethargy? Or does it need time to build-up / only minimise the onset of lethargy?

    Edit: Wrong thread. I'll leave it here just so you can see how I stupid I am.

  18. Quote Originally Posted by Eight View Post
    Proper amateur question here: would taking a large(ish) (still safe, of course) dose of 4-andro late in a cycle help with lethargy? Or does it need time to build-up / only minimise the onset of lethargy?
    Depends on what you are taking and how long you have left.

  19. Quote Originally Posted by Ihatbanas View Post
    That's the thing I already do lots of cardio, and I don't feel that extra push..
    Some said they don't feel anything on it and other swear by it.
    You got the product from a good source (not ebay we hope ).
    Blue/white caps.

    I'm on 7mg/day OL ghar1ne and today I had a 30 min low intense cardio with no problem (could easily gone on for 30 more min) and some abs after that.
    I also have a god cardio capacity but i though my self feel a better recovery after the cardio as well as a more steady breathing. So i did not get a push like a PWO but i eased though it with what feel like a less effort from what it otherwise would be.
    But only 4 days in so placebo could be all over the place.

  20. Quote Originally Posted by xo0ox View Post
    Depends on what you are taking and how long you have left.
    Oops, posted this is the wrong thread. Lol. But thanks mate.

  21. Quote Originally Posted by bigdavid View Post
    I recently got a bottle of GW with the thought that it may offset the low endurance/lethargy of doing a short course of an oral methylated anabolic.. or offset fatigue from tren use.. It could be very helpful in that regard if it indeed does improve endurance capacity.. Thoughts on this anyone?
    Like said before, avoid this since GW promotes scar tissue in the liver over regeneration.

    We found that GW501516 treatment enhanced the fibrotic response. Compared to the other experimental groups, CCl4/GW501516-treated wild type mice exhibited increased expression of various profibrotic and pro-inflammatory genes, such as those involved in extracellular matrix deposition and macrophage recruitment. Importantly, compared to healthy liver, hepatic fibrotic tissues from alcoholic patients showed increased expression of several PPAR target genes, including phosphoinositide-dependent kinase-1, transforming growth factor beta-1, and monocyte chemoattractant protein-1. GW501516 stimulated HSC proliferation that caused enhanced fibrotic and inflammatory responses, by increasing the phosphorylation of p38 and c-Jun N-terminal kinases through the phosphoinositide-3 kinase/protein kinase-C alpha/beta mixed lineage kinase-3 pathway.

    Conclusions

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519722/

  22. IIRC Basically, be ****ing careful with cardarine if you're taking anything that messes with your liver. It may make it worse.

  23. Quote Originally Posted by Eight View Post
    If your cardio is already decent then cardarine is not going to make you feel like superman.

    It's more subtle than that. Aside from time trials, I found that once I really started pushing myself, my leg muscles were giving out before my lungs while I was on the stuff.
    Ok this is what my Trainning looks like. I don't think I can add more cardio/high resistance

    Monday through Thursday crossfit class.

    Once a week track work

    Once a week swimming intervals for 45 to 60 mins.

    Once a week soccer game for 2 hours

    Once a week Olympic lifting

    Once a week I target a specific group muscle.

    Plus my usual stretching and warm ups.

    I've lost close to 20 lbs in 3 months. Went from 180 lbs to 159 and now I'm around 162.

    I want to be 10% bf

  24. Quote Originally Posted by xo0ox View Post
    Like said before, avoid this since GW promotes scar tissue in the liver over regeneration.

    We found that GW501516 treatment enhanced the fibrotic response. Compared to the other experimental groups, CCl4/GW501516-treated wild type mice exhibited increased expression of various profibrotic and pro-inflammatory genes, such as those involved in extracellular matrix deposition and macrophage recruitment. Importantly, compared to healthy liver, hepatic fibrotic tissues from alcoholic patients showed increased expression of several PPAR target genes, including phosphoinositide-dependent kinase-1, transforming growth factor beta-1, and monocyte chemoattractant protein-1. GW501516 stimulated HSC proliferation that caused enhanced fibrotic and inflammatory responses, by increasing the phosphorylation of p38 and c-Jun N-terminal kinases through the phosphoinositide-3 kinase/protein kinase-C alpha/beta mixed lineage kinase-3 pathway.

    Conclusions

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519722/
    I wish I had the time to respond to all the issues I have with this study and it’s relevance to this discussion. Mouse models are good for detailing fine biochemical pathways, but they are lousy in regards to extrapolation/application to human physiology (along with a multitude of other factors). Case in point: do you know how many treatments for mouse models of ALS have been “successful”? Do you know how many of those same treatment modalities ended up being efficacious in human trials? Long story short: we haven’t made much process in the past 30 years...

    Also, one thing I have to respond to specifically from this study is the method of administration: intraperitoneal injection... do you know what organs have direct exposure in that cavity? The liver for one. And before you say that taking a drug orally makes it pass through the liver anyway...my response is that the surface of the liver is particularly susceptible to inflammatory mediators, and doesn’t have the same metabolic capacity or blood flow to deal with direct stress. Also not all of an orally administered drug is metabolized directly by the liver. It only gets a certain percent of what you initially ingest... and then subsequent passes through the liver ensure that the detox pathways don’t get overloaded. Intraperitoneal injection forces the liver to deal with direct exposure all at once and that also skews the comparison. And sure... this may only account for 5-10% of the results (if even that, who knows) but there are more issues that in total make the jump to humans rather speculative.

    I hear you and understand your skepticism and caution in regards to the theoretical risk associated with this compound, but honestly it is no more dangerous or toxic than a methylated PH cycle. And for this one study showing harm there are even more showing the opposite (let’s not forget selection bias...and of course the trap of latching on to information that confirms what was initially believed). Etc etc etc... (also if this comes across as aggressive, I apologize...this is just how my thoughts flow, nothing personal...INTP here lol).

  25. Quote Originally Posted by Jeffcarelly View Post
    So I'm on day two of taking Cardarine got it from a reputable source SARMS1 liquid version.. taste like crap so I'm pretty sure I got the right stuff.. I'm wondering if anyone else here has taken it before.. this will be my first time using it.. I heard rumors of shedding lots of fat but I hear from others all it did was increase endurance but no fat loss..

    I'm also stacking it with n2slin.. But I got a pill version from N2B and I'm not sure if it's just bunk.
    Cardarine did absolutely nothing for me. I took it from 2 different brands while on diet and it didnt work at all. Its a complete waste of money. Stick with albuterol and eca with ketotifen
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