Lowering blood pressure while getting shredded, have a look!

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  1. Lowering blood pressure while getting shredded, have a look!


    The "wonder" drug is called: Telmisartan

    It's a prescription med to lower BP.
    Following are excerpts of study findings and below the relevant studies:

    -In addition to blocking the RAS, telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism. It is believed that telmisartan’s dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD).[7]

    Telmisartan's activity at the peroxisome proliferator-activated receptor delta (PPAR-δ) receptor has prompted speculation around its potential as a sport doping agent as an alternative to GW 501516.[8] Telmisartan activates PPAR-δ receptors in several tissues.[9][10][11][12]

    https://en.wikipedia.org/wiki/Telmisartan

    -treatment of insulin resistance, diabetes and metabolic syndrome, whose activation is also correlated to anti-inflammatory and, finally, anti-atherosclerotic properties. Telmisartan shows peculiar features that go beyond blood pressure control. It presents promising and unique protective properties against target end-organ damage, potentially able to open a scenario of new therapeutic approaches to cardiovascular disease.

    https://www.ncbi.nlm.nih.gov/pubmed/22077832

    -In conclusion, these results suggest that telmisartan is more effective at protecting renal function and vascular endothelial function, and at improving arteriosclerosis than the calcium channel blocker in patients with essential hypertension.

    https://www.ncbi.nlm.nih.gov/pubmed/17137211

    -There were significant reductions in visceral fat. In conclusion, telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin.

    https://www.ncbi.nlm.nih.gov/pubmed/18344626

    -Telmisartan improves both hemodynamic and metabolic abnormalities found in hypertensive patients with obesity. The additional benefits may be partly due to visceral fat remodeling.

    https://www.ncbi.nlm.nih.gov/pubmed/22008920

    -Telmisartan is a potent target for prevention and treatment in human prostate cancer.

    https://www.ncbi.nlm.nih.gov/pubmed/18636189


    And much more....

    I'm on this drug for about 7 weeks with awesome effects in reducing my mid section, even with a normal diet.
    Me: 49yo/5'8/215lbs/18-20% BF
    Life is fair it's your expectations that aren't.


  2. What about the side effects.. there are some nasty ones
    Now remember, when things look bad and it looks like you're not gonna make it, then you gotta get mean. I mean plumb, mad-dog mean. 'Cause if you lose your head and you give up then you neither live nor win. That's just the way it is.
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  3. Quote Originally Posted by DennisTheDane View Post
    What about the side effects.. there are some nasty ones
    Surprisingly, the list of common sides is short and really harmless looking.
    Like with ALL drugs, side effects may occur. I did not feel any negative sides -and no, no nasty ones are reported, if nasty means life threatening.

    https://www.drugs.com/sfx/telmisartan-side-effects.html

    One thing to note:
    -Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, indomethacin) may decrease telmisartan's effectiveness and the risk of kidney problems may be increased

    Well, Telmisartan has an anti inflammatory effect by itself
    Life is fair it's your expectations that aren't.

  4. For all you "AAS abusers" and "Hawthorn-eaters", it's really worth to look into this, not much feedback here.



    Anyone?
    Life is fair it's your expectations that aren't.

  5. I'd be up for trying this on cycle, always in to prevent BP issues! What are the possible "side effects"?
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  6. Quote Originally Posted by Juicedeez utz View Post
    I'd be up for trying this on cycle, always in to prevent BP issues! What are the possible "side effects"?
    They are sick! But look at a glass of asprin... They can kill you hahahaha!
    I found that the sides are like any other BP meds. You have to be carefull not to crash your BP while on...It can get to low.
    Now remember, when things look bad and it looks like you're not gonna make it, then you gotta get mean. I mean plumb, mad-dog mean. 'Cause if you lose your head and you give up then you neither live nor win. That's just the way it is.
  7. May I suggest using this app to track your bloodwork tests:
    myBloodTracker for IPhone and IPad
    https://appsto.re/us/vvMndb.i

  8. Interesting topic. Also "Hawthorne eaters " implies something negative about HB. What's the drawback?

  9. Quote Originally Posted by celc5 View Post
    Interesting topic. Also "Hawthorne eaters " implies something negative about HB. What's the drawback?
    "Hawthorne-eaters" are usually guys who inject UGL AAS into their bodies, not knowing whats in it -but use "natural supplements" to try to control their blood pressure (hilarious, don't you think?).

    Hawthorne doesn't even come close to Telmisartans effects.
    Life is fair it's your expectations that aren't.

  10. @kenpoengineer 's link summarizes Telmisartan nicely:

    Telmisartan

    by Bill Roberts – Telmisartan (Micardis) is an oral prescription medication most commonly used to treat hypertension, including mild hypertension where blood pressure is only moderately elevated or borderline. If choosing to self-medicate for mild hypertension or borderline high blood pressure, telmisartan is an excellent or even best choice.

    As elevated blood pressure is often an undesired side effect of anabolic steroid cycles and can even limit use of androgens, this use of telmisartan is already enough to make the drug of value to many.

    However, telmisartan also has an entirely different category of use, due to having quite a number of other interesting properties which can be valuable in some instances.

    I don’t know of a term to describe this second category of use. The closest is a category I call “metabolic healing,” though that’s not a scientific term, in which I’ve been working to develop new administrations of natural product compounds. This has been an ongoing process I haven’t yet completed, but to me it’s extremely promising. What I mean by this category is, use of substances or combinations of substances to change gene expression in a way working to correct damages in gene expression associated with age, development of insulin resistance, and/or chronic poor diet. The goal is to return the expression (mRNA production) levels of these genes for receptors, cofactors, and cytokines to healthy values. This also is generally what telmisartan does, to a large extent, in a drug that’s already available and fairly easily obtained.

    Benefits can include improvement to fat loss, endurance, insulin sensitivity, reduction of risk of atherosclerosis, stroke, and of heart attack, and possible benefit to brain health. In some cases mood or energy can be improved as well.
    When to use telmisartan

    If blood pressure needs to be moderated, I’d certainly consider using telmisartan. If there is no such need, factors that could suggest its use include interest in reducing visceral fat, of improving impaired insulin sensitivity, of reducing risk of atherosclerosis, or depending on personal interest, of possibly improving brain health and function.

    Reasons not to use telmisartan could include unwillingness to accept the risk of possible side effects, or unwillingness to shift the balance of fat loss towards visceral fat loss versus subcutaneous fat loss. In general, if dieting and training achieve only the same bodyfat percentage despite the positive effects of telmisartan, appearance could be smoother due to the same amount of bodyfat being present but with less of it stored as unhealthful visceral fat. On the other hand, if taking advantage of improved loss of visceral fat with telmisartan to achieve a lower bodyfat percentage, then there’s no smoothness penalty. However, when aiming for contest condition there’s a certain amount of fat that the body must retain: theoretically, reducing visceral fat in this case might force retention of a greater amount of subcutaneous fat. So I wouldn’t advise telmisartan use in the last few weeks before a bodybuilding contest.
    How to use telmisartan

    To reduce risk of atherosclerosis, cardiovascular disease, or stroke where risk is only moderate in the first place, I suggest a dose from 20 to 40 mg taken orally once per day. Dosing would be the same where the interest is slowing loss of brain function with age, or potentially improving brain function.

    For possible improvement in fat loss, particularly of visceral fat, or improvement of endurance I suggest dosing of 80-160 mg/day. Starting dose, however, generally should be only 40 mg/day until tolerance is assessed.

    While it’s not required and telmisartan users in general do not do so, when using this drug I suggest supplementing with oleuropein 200-400 mg/day and Vitamin D 5000 IU/day. These are to reduce or perhaps eliminate two activities of telmisartan that I would not consider desirable for physique or performance enhancement, though they add to its medical use.

    Telmisartan should not be used in combination with a diuretic, and I would avoid allowing severe dehydration while using this drug.

    Blood pressure should be monitored while using telmisartan. Typically, any decrease of blood pressure is simply to healthful levels or more-nearly healthful levels, and those who do not have high blood pressure see no decrease with telmisartan. Still, there can be exceptions, so this should be watched.

    Lastly, I would cycle telmisartan use rather than use it continuously. There’s no proof of what cycling method might be optimal, but for example I’d suggest being “off” about as many weeks per year as “on” as a minimum. This is not because of proven problem, but simply because I expect the benefits can be fully or nearly fully realized with this amount of use, and where any of the changes to gene expression or receptor blocking might be adverse in the individual case rather than beneficial, this will then be no more than half the time.
    Pharmacological effects of telmisartan

    Briefly, telmisartan is in the pharmacological class of angiotensin receptor blocker, but has many effects on gene expression which generally are favorable to metabolism, endurance, and body composition. Results can include increasing PPAR-delta, GLUT4, UCP1, SIRT1, AMPK, HDL, phospho-AMPK-α, hormone lipase, adiponectin, leptin, CRP, IL-1β, and fatty acid oxidation in muscle; decreasing aldosterone, TNFα, LDL, serum triglycerides, inflammation in adipose tissue, and fasting blood glucose; and inhibiting adipogenesis.

    All these can be helpful activities for fat loss or for improved health; PPAR-delta activation also can result in increased muscle endurance via increasing oxidative capacity of Type II fibers.

    Telmisartan also is a partial agonist of PPAR-gamma, which while useful for those with diabetes, I would not choose for a physique-enhancing drug because activating PPAR-gamma works towards enhancing fat storage. Telmisartan has so many activities working against fat storage that overall it’s unlikely to gain bodyfat from the PPAR-gamma mechanism, but still I would prefer to minimize this activation. Oleuropein supplementation can work towards blocking this activation, so it’s a suggested supplement to use in combination with telmisartan.

    The other undesired activity is partial blocking of the 1,25-dihydroxyvitamin-D receptor. I would address this with supplementation of Vitamin D.
    Muscle fiber type switching?

    Telmisartan has a biochemical effect on muscle cells which is very similar to the effect of exercise. A consequence of this is increased oxidative capacity of Type II muscle fibers, which may be called “switching” from Type IIb to Type IIa. It’s possible that such switching could be a significant concern for powerlifters, Olympic lifters, shotputters, or other extremely explosive athletes. On the other hand, ordinary resistance training also induces the same effect, and any such effect is likely reversible in any case.

    Switching between Type II and Type I fibers, which would be of more concern, does not happen with telmisartan so far as is known. (Such switching in humans appears possible only by changing the nerve to which the muscle fiber is connected.

    In general, it’s not necessary to be concerned that telmisartan use will result in a bodybuilder-type physique becoming an endurance athlete-type physique. But increased ability to do high rep work is common.
    Telmisartan and left ventricle hypertrophy

    There’s no human evidence as yet as to whether telmisartan use may reverse or partially reverse anabolic steroid induced left ventricle hypertrophy (LVH), but in animal models telmisartan can act to reverse LVH. Time will tell whether reversal or partial reversal of anabolic steroid-induced LVH might be yet another benefit of telmisartan use.
    Possible side effects of telmisartan

    While telmisartan is generally well-tolerated, potential side effects include headache, dizziness, diarrhea, tiredness, and similar complaints though these are relatively uncommon. Serious side effects of rhabdomyolysis and angioedema are known but very rare. Allergic response is possible. Discontinue telmisartan use if experiencing serious side effects.

    A fuller listing of potential side effects may be found here. It should be kept in mind that nearly every side effect mentioned is also reported by the placebo group, and generally with similar frequency.
    Conclusion

    Telmisartan can be useful for moderating blood pressure of those with elevated blood pressure, both when using anabolic steroids and when not doing so, and also can improve endurance, aid fat loss, and potentially may improve long term health.
    Source:
    https://thinksteroids.com/steroid-profiles/telmisartan/
    Life is fair it's your expectations that aren't.

  11. Quote Originally Posted by hairygrandpa View Post
    "Hawthorne-eaters" are usually guys who inject UGL AAS into their bodies, not knowing whats in it -but use "natural supplements" to try to control their blood pressure (hilarious, don't you think?).

    Hawthorne doesn't even come close to Telmisartans effects.
    Ha Ha! Yes, makes sense in that context!

    For the gen pop avid gym goer, u still believe HB can lower BP a few points though, right?

  12. Quote Originally Posted by celc5 View Post
    Ha Ha! Yes, makes sense in that context!

    For the gen pop avid gym goer, u still believe HB can lower BP a few points though, right?
    Yes, sure! Especially for young people who do occasionally PH cycles, HB is fine.

    I got in trouble while on NPP. BP was 180/120. No amount of Hawthorne Berry extract -or garlic would have an impact on that numbers.
    Now that I'm on Telmisartan, my BP is optimal and I'm getting lean!
    My bet is: for chubby -beer-belly dudes around their 50's, Telmisartan could be the answer to all prayers.
    Life is fair it's your expectations that aren't.

  13. LMAO I love your posts! I share ur internet dad-humor

  14. In on this...I have a bunch of this stuff on hand but for some reason I stopped using it. I need to start back up....I stopped using it because I was having vision issues and wasn't sure if it was from Nolvadex or Telmisartan...and then I got checked, everything was fine, I think my contact prescription was just bad, and I never got back to using it. You may have me interested again.

  15. Quote Originally Posted by HIT4ME View Post
    In on this...I have a bunch of this stuff on hand but for some reason I stopped using it. I need to start back up....I stopped using it because I was having vision issues and wasn't sure if it was from Nolvadex or Telmisartan...and then I got checked, everything was fine, I think my contact prescription was just bad, and I never got back to using it. You may have me interested again.
    Me too, I have vision issues. When I look in the mirror I always see this old fugger looking at me.
    Life is fair it's your expectations that aren't.

  16. Quote Originally Posted by hairygrandpa View Post
    Me too, I have vision issues. When I look in the mirror I always see this old fugger looking at me.
    Wait, are you suggestion that the reason my abs were blurry in the mirror wasn't because of my vision?

  17. Quote Originally Posted by HIT4ME View Post
    Wait, are you suggestion that the reason my abs were blurry in the mirror wasn't because of my vision?
    What? Your abs were blurry? That is just fat, son.

    My guess is that telmisartan is most useful for people with more visceral fat deposits, mainly older "non-moving" individuals -and formerly heavy drinkers...
    Life is fair it's your expectations that aren't.

  18. Quote Originally Posted by hairygrandpa View Post
    What? Your abs were blurry? That is just fat, son.

    My guess is that telmisartan is most useful for people with more visceral fat deposits, mainly older "non-moving" individuals -and formerly heavy drinkers...
    Yeah. Yeah you got me.

  19. Quote Originally Posted by HIT4ME View Post
    Yeah. Yeah you got me.
    My guess is, for you it would be only beneficial if using it for augmenting metabolism, as from what I could see, there is not much visceral fat on you. If you start using it, please review your findings! How is your BP?
    Life is fair it's your expectations that aren't.

  20. Seems amazing, but I don't like to take medicine, I prefer to naturally treatment.

  21. Quote Originally Posted by David Smith View Post
    Seems amazing, but I don't like to take medicine, I prefer to naturally treatment.
    That is fine -as long as you stay away from most oral steroids -and heavy doses of injectable AAS.
    The thing is, high BP is a very known side effect when on cycle. Natural supps are often not enough.

    People who like Cardarine (GW) should consider Telmisartan, its well researched and has you not wondering if it causes cancer, like GW.
    Life is fair it's your expectations that aren't.

  22. Well this thread was entertaining haha

  23. i am on it since monday due to high bp..
    currently taking 20mg a day but i guess i have to increase to 40 or 60 to get desired bp (i would like to be @ 120/70)
    i have pushed to get this bp med since its the best and if you already have to take something.. why not the best for our lovely sport?

  24. Quote Originally Posted by ManuR View Post
    i am on it since monday due to high bp..
    currently taking 20mg a day but i guess i have to increase to 40 or 60 to get desired bp (i would like to be @ 120/70)
    i have pushed to get this bp med since its the best and if you already have to take something.. why not the best for our lovely sport?
    I'm also now on Cialis, 10mg/day, vasodilator, gives you awesome pumps in the gym, eases symptoms of enlarged prostate, lowers BP.

    Downside:
    -stuffy nose, congestion
    -acid reflux
    Life is fair it's your expectations that aren't.

  25. Quote Originally Posted by ManuR View Post
    i am on it since monday due to high bp..
    currently taking 20mg a day but i guess i have to increase to 40 or 60 to get desired bp (i would like to be @ 120/70)
    i have pushed to get this bp med since its the best and if you already have to take something.. why not the best for our lovely sport?
    A good friend suggested it and suddenly I see this thread popping. I am here for the knowledge. Thanks bro
    Anything, just ask
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