Lowering blood pressure while getting shredded, have a look!

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  1. Quote Originally Posted by GreekTheBrick View Post
    A good friend suggested it and suddenly I see this thread popping. I am here for the knowledge. Thanks bro
    this friend is me bro :P


  2. Quote Originally Posted by ManuR View Post
    this friend is me bro :P
    True bro!
    Anything, just ask
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  3. Quote Originally Posted by hairygrandpa View Post
    The "wonder" drug is called: Telmisartan

    It's a prescription med to lower BP.
    Following are excerpts of study findings and below the relevant studies:

    -In addition to blocking the RAS, telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism. It is believed that telmisartan’s dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD).[7]

    Telmisartan's activity at the peroxisome proliferator-activated receptor delta (PPAR-δ) receptor has prompted speculation around its potential as a sport doping agent as an alternative to GW 501516.[8] Telmisartan activates PPAR-δ receptors in several tissues.[9][10][11][12]

    https://en.wikipedia.org/wiki/Telmisartan

    -treatment of insulin resistance, diabetes and metabolic syndrome, whose activation is also correlated to anti-inflammatory and, finally, anti-atherosclerotic properties. Telmisartan shows peculiar features that go beyond blood pressure control. It presents promising and unique protective properties against target end-organ damage, potentially able to open a scenario of new therapeutic approaches to cardiovascular disease.

    https://www.ncbi.nlm.nih.gov/pubmed/22077832

    -In conclusion, these results suggest that telmisartan is more effective at protecting renal function and vascular endothelial function, and at improving arteriosclerosis than the calcium channel blocker in patients with essential hypertension.

    https://www.ncbi.nlm.nih.gov/pubmed/17137211

    -There were significant reductions in visceral fat. In conclusion, telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin.

    https://www.ncbi.nlm.nih.gov/pubmed/18344626

    -Telmisartan improves both hemodynamic and metabolic abnormalities found in hypertensive patients with obesity. The additional benefits may be partly due to visceral fat remodeling.

    https://www.ncbi.nlm.nih.gov/pubmed/22008920

    -Telmisartan is a potent target for prevention and treatment in human prostate cancer.

    https://www.ncbi.nlm.nih.gov/pubmed/18636189


    And much more....

    I'm on this drug for about 7 weeks with awesome effects in reducing my mid section, even with a normal diet.
    Me: 49yo/5'8/215lbs/18-20% BF
    Do you think telmisartan and UDCA/TUDCA (and maybe NAC?)will be enough as a cycle support for any sensible cycle? Considering that BP, prostate and liver health are our mainly concerns?
    Anything, just ask

  4. Quote Originally Posted by GreekTheBrick View Post
    Do you think telmisartan and UDCA/TUDCA (and maybe NAC?)will be enough as a cycle support for any sensible cycle? Considering that BP, prostate and liver health are our mainly concerns?
    hey bro!
    for me, telmisartan is strong enough to get my bp down to 115/68 (last measurement @ docs office) from 152/83 @40mg/day.
    so i would say yes, it is enough for bp in my opinion. (you would have to up the dose to 60/80 maybe if you are on strong stuff that has strong estrogen conversion..)

  5. Quote Originally Posted by GreekTheBrick View Post
    Do you think telmisartan and UDCA/TUDCA (and maybe NAC?)will be enough as a cycle support for any sensible cycle? Considering that BP, prostate and liver health are our mainly concerns?
    Telmisartan is, IMHO, better for controlling BP than using hawthorn berry extract. Keep in mind that Telmisartan is lowering BP moderately, if on stuff like D-bol, Deca, NPP, Anadrol -and/or high doses of test, taking Telmisartan may not be sufficient. I would consider having a diuretic at hand and a vasodilator like Cialis.

    Tudca and Nac for liver health is nowadays the mainstream approach.

    Please remember, Telmisartan can't be taken with some NSAID's. It may increase the risk of a decline in kidney function.
    Life is fair it's your expectations that aren't.
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  6. Quote Originally Posted by hairygrandpa View Post
    Telmisartan is, IMHO, better for controlling BP than using hawthorn berry extract. Keep in mind that Telmisartan is lowering BP moderately, if on stuff like D-bol, Deca, NPP, Anadrol -and/or high doses of test, taking Telmisartan may not be sufficient. I would consider having a diuretic at hand and a vasodilator like Cialis.

    Tudca and Nac for liver health is nowadays the mainstream approach.

    Please remember, Telmisartan can't be taken with some NSAID's. It may increase the risk of a decline in kidney function.
    It seems the benefits are too many to pass! I will definitely add it to my upcoming cycle! Doing homework based on what you said and the links you provided. Thanks man
    Anything, just ask

  7. Quote Originally Posted by ManuR View Post
    hey bro!
    for me, telmisartan is strong enough to get my bp down to 115/68 (last measurement @ docs office) from 152/83 @40mg/day.
    so i would say yes, it is enough for bp in my opinion. (you would have to up the dose to 60/80 maybe if you are on strong stuff that has strong estrogen conversion..)
    Thats a big difference man. Were you on cycle during the two measurements?
    Anything, just ask

  8. I've been using Telmisartan for 3 weeks, and I believe I am noticing some subtle improvement in leptin response. I have been trying to figure out why I am NEVER really full, or even satisfied from food. I don't even have a stomach stretch pain that tells me to stop eating.

    Since on Telmisartan I find that I am naturally finding satisfaction in small treats. Before, once I started eating, say, a peanut butter cup from a bag of peanut butter cups, I would keep going and going until I ran out of PB cups. There was no real sense of satisfaction. Now, I eat 1 PB cup and I feel happy I did and don't need to eat more. I wasn't expecting this, and it may be in my head or something else, but this is exactly what I've been trying to achieve for a LOOOONG time now.

    ACE inhibitors do seem to have some influence on leptin ...so it makes some sense. And it isn't a super crazy powerful appetite suppressant. I almost wouldn't even call it a suppressant - it just brought an ability to be satisfied that is suprising. It would be good to see if others have a similar experience.

  9. Quote Originally Posted by HIT4ME View Post
    I've been using Telmisartan for 3 weeks, and I believe I am noticing some subtle improvement in leptin response. I have been trying to figure out why I am NEVER really full, or even satisfied from food. I don't even have a stomach stretch pain that tells me to stop eating.

    Since on Telmisartan I find that I am naturally finding satisfaction in small treats. Before, once I started eating, say, a peanut butter cup from a bag of peanut butter cups, I would keep going and going until I ran out of PB cups. There was no real sense of satisfaction. Now, I eat 1 PB cup and I feel happy I did and don't need to eat more. I wasn't expecting this, and it may be in my head or something else, but this is exactly what I've been trying to achieve for a LOOOONG time now.

    ACE inhibitors do seem to have some influence on leptin ...so it makes some sense. And it isn't a super crazy powerful appetite suppressant. I almost wouldn't even call it a suppressant - it just brought an ability to be satisfied that is suprising. It would be good to see if others have a similar experience.
    ....
    Last edited by rtmilburn; 06-04-2017 at 05:27 PM. Reason: I was wrong

  10. What I noted most is the up regulation of my metabolism. Only looking at one noodle made me fat.
    Even though I'm 218 lbs, my maintenance cals were around 2300. Now I'm eating in excess of 3000kcal/day without fat gain.
    I'm on 80mg Telmisartan/day.
    For me the effect on my BP is not that pronounced, like 8-12 points less on the systolic value and only 3-5 points to the diastolic value.
    Life is fair it's your expectations that aren't.

  11. Quote Originally Posted by hairygrandpa View Post
    What I noted most is the up regulation of my metabolism. Only looking at one noodle made me fat.
    Even though I'm 218 lbs, my maintenance cals were around 2300. Now I'm eating in excess of 3000kcal/day without fat gain.
    I'm on 80mg Telmisartan/day.
    For me the effect on my BP is not that pronounced, like 8-12 points less on the systolic value and only 3-5 points to the diastolic value.
    Really even with Cialis? I would expect much more.
  12. Lowering blood pressure while getting shredded, have a look!


    Quote Originally Posted by rtmilburn View Post
    Telmisartan is not an ace inhibiter it is a ppar-(not sure which one) antagonist.
    Its main MOA (very good for controlling blood pressure) is being an Angiotensin II receptor, type 1 antagonist. It does display high affinity to ppar delta/gamma.
    OLYMPUS LABS
    My posts outside of OL threads are my opinion, don't take them as offensive!
    ADAM@OLYMPUS-LABS.COM

  13. Quote Originally Posted by NoAddedHmones View Post
    Its main MOA (very good for controlling blood pressure) is being an Angiotensin II receptor, type 1 antagonist. It does display some affinity to ppar gamma.
    Really? My bad. I need to keep up with this stuff more. Just been busy as hell for the past year. Thanks for letting me know

  14. Quote Originally Posted by NoAddedHmones View Post
    Its main MOA (very good for controlling blood pressure) is being an Angiotensin II receptor, type 1 antagonist. It does display high affinity to ppar delta/gamma.
    Wonder if it would have synergy with gw?

  15. Quote Originally Posted by rtmilburn View Post
    Really? My bad. I need to keep up with this stuff more. Just been busy as hell for the past year. Thanks for letting me know
    Here's another fun fact, in theory one could use it when using long acting beta agonists to protect against left Ventricular hypertrophy and simultaneously enhancing fat loss.
    OLYMPUS LABS
    My posts outside of OL threads are my opinion, don't take them as offensive!
    ADAM@OLYMPUS-LABS.COM

  16. Quote Originally Posted by rtmilburn View Post
    Really even with Cialis? I would expect much more.
    Cialis had a very bad side effect at 10mg/day. I'm not talking about the constant boner here. Pain in the back and hams, a side effect only 3-7% of people get.
    The pump in the gym is phenomenal from cialis, I had to keep taking it somehow.
    Now I'm taking 5mg every 3 days, with only slight pain.
    Life is fair it's your expectations that aren't.

  17. Quote Originally Posted by NoAddedHmones View Post
    Here's another fun fact, in theory one could use it when using long acting beta agonists to protect against left Ventricular hypertrophy and simultaneously enhancing fat loss.
    It's superior to some beta blockers and even achieves regression of left ventricular hypertrophy (mainly caused by long term high BP in obese persons).

    https://www.ncbi.nlm.nih.gov/pubmed/23998064
    Life is fair it's your expectations that aren't.

  18. Quote Originally Posted by hairygrandpa View Post
    Cialis had a very bad side effect at 10mg/day. I'm not talking about the constant boner here. Pain in the back and hams, a side effect only 3-7% of people get.
    The pump in the gym is phenomenal from cialis, I had to keep taking it somehow.
    Now I'm taking 5mg every 3 days, with only slight pain.
    Okay I see

  19. Quote Originally Posted by rtmilburn View Post
    Okay I see
    Was thinking to switch to viagra pre-workout, the guys from "enhanced athlete" doing it, as it has a way shorter HL.
    Not knowing what to do with all the cialis I bought, I'm stuck with it for months at low dose now, LOL.

    Life is fair it's your expectations that aren't.

  20. Quote Originally Posted by NoAddedHmones View Post
    Its main MOA (very good for controlling blood pressure) is being an Angiotensin II receptor, type 1 antagonist. It does display high affinity to ppar delta/gamma.
    Quote Originally Posted by rtmilburn View Post
    Really? My bad. I need to keep up with this stuff more. Just been busy as hell for the past year. Thanks for letting me know
    RTMilburn - you and I were both slightly wrong and @NoAddedHmones is more correct.

    If I am thinking correctly, what Noaddedhmones is saying is that this is NOT an ACE inhibitor (which makes you right) but actually antagonizes the Angiotensin II receptor site. The ACE Inhibitor action prevents angiotensin converting enzyme from doing its job, which lowers Angiotensin II. Telmisartan doesn't lower Angiotensin II - it binds the receptor site that A2 binds to, so you can still have it floating around and it won't have anything to bind to and cause an effect. This kind of explains why it may be a weaker BP drug than something like Lisinopril.

    However, a logical jump is that if ACE inhibitors increase leptin or leptin sensitivity, then preventing A2 from doing it's job may also do the same thing (or may not).

  21. Quote Originally Posted by NoAddedHmones View Post
    Here's another fun fact, in theory one could use it when using long acting beta agonists to protect against left Ventricular hypertrophy and simultaneously enhancing fat loss.
    Quote Originally Posted by hairygrandpa View Post
    It's superior to some beta blockers and even achieves regression of left ventricular hypertrophy (mainly caused by long term high BP in obese persons).

    https://www.ncbi.nlm.nih.gov/pubmed/23998064
    This is actually one of the things that attracted me to Telmisartan - a weight loss drug that may help prevent damage caused by T3 and/or clen usage.

  22. Quote Originally Posted by HIT4ME View Post
    RTMilburn - you and I were both slightly wrong and @NoAddedHmones is more correct.

    If I am thinking correctly, what Noaddedhmones is saying is that this is NOT an ACE inhibitor (which makes you right) but actually antagonizes the Angiotensin II receptor site. The ACE Inhibitor action prevents angiotensin converting enzyme from doing its job, which lowers Angiotensin II. Telmisartan doesn't lower Angiotensin II - it binds the receptor site that A2 binds to, so you can still have it floating around and it won't have anything to bind to and cause an effect. This kind of explains why it may be a weaker BP drug than something like Lisinopril.

    However, a logical jump is that if ACE inhibitors increase leptin or leptin sensitivity, then preventing A2 from doing it's job may also do the same thing (or may not).
    Yep sounds like you are correct

  23. Cool thread. Late to the party
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  24. Interested.
    Training & everything else log: http://anabolicminds.com/forum/workout-logs/275307-bam-bam-goes-30.html

  25. Some of these popular ACE's and ARB's can cause kidney stress. Just wanted to add this caveat to this cool thread.
    A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
    "The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction"
    Proverbs 1:7
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