Q&A for BloodShot

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Supplement Information​

Citrulline Malate 4000mg

L-Citrulline is used as a sports performance and cardiovascular health supplement. L-Citrulline supplementation results in reduced fatigue and improved endurance for both aerobic and anaerobic prolonged exercise. There is not enough evidence to support the claim that L-citrulline supplementation improves power output during exercise.

Supplementing L-citrulline also increases ornithine and arginine plasma content. This means L-citrulline supplementation improves the ammonia recycling process and nitric oxide metabolism. L-citrulline is also used to alleviate erectile dysfunction caused by high blood pressure.

After supplementation, L-citrulline is converted into arginine in the kidneys. Supplemental L-arginine provides a spike of L-arginine in plasma, while supplemental L-citrulline increases arginine plasma levels over a longer period of time.

Beta Alanine 2000mg

Beta-alanine is a modified version of the amino acid alanine.

Beta-alanine has been shown to enhance muscular endurance. Many people report being able to perform one or two additional reps in the gym when training in sets of 8–15 repetitions. Beta-alanine supplementation can also improve moderate- to high-intensity cardiovascular exercise performance, like rowing or sprinting.

When beta-alanine is ingested, it turns into the molecule carnosine, which acts as an acid buffer in the body. Carnosine is stored in cells and released in response to drops in pH. Increased stores of carnosine can protect against diet-induced drops in pH (which might occur from ketone production in ketosis, for example), as well as offer protection from exercise-induced lactic acid production.

Large doses of beta-alanine may cause a tingling feeling called paresthesia. It is a harmless side effect.

Rhodiola Rosea 300mg

Rhodiola rosea is a herb in the rhodiola genera (Crassulaceae family) which has traditional usage as an anti-fatigue agent and adaptogen compound, and rhodiola is likely the second most popular adaptogen (second only to panax ginseng).

In regards to fatigue, rhodiola appears to be able to significantly reduce the effects of prolonged and minor physical exhaustion that results in fatigue. This is more related to stress and the 'burnout' effect, or prolonged but low intensity physical exercise. There is some limited evidence that parameters of physical exercise can be improved with rhodiola, but this appears to be limited to untrained persons with numerous studies on trained athletes suggesting that rhodiola does not have an acute ergogenic effect. Despite this, rhodiola appears to be highly reliable in reducing fatigue symptoms and improving symptoms of stress (and secondary to that, well-being) in persons fatigued from non-exercise related stressors.

Rhodiola can improve cognitive functioning in persons who experience a reduction in fatigue, but there is insufficient evidence to support an outright increase in cognition (which should occur in non-fatigued persons) and not enough studies have assessed cognitive decline for conclusions to be made.

Other potential uses of rhodiola include preliminary evidence that it is highly neuroprotective against toxins (requires more evidence) and that ingestion of rhodiola or its active component can reduce stress-induced binge eating in female rats. In the brain, rhodiola appears to be highly serotonergic (increases serotonin) and reduces corticosteroids; the inhibition of monoamine oxidases (MAOs) commonly attributed to rhodiola may not be relevant following oral ingestion of rhodiola, however.

Rhodiola may also promote longevity, with preliminary (non-mammalian) evidence suggesting up to a 20% increase in lifespan secondary to mechanisms that are indepedent of caloric restriction. Although very promising, mammalian evidence is needed to confirm.

Caffeine 200mg

Caffeine comes from coffee beans, but it can also be synthesized in a laboratory. It has the same structure whether it’s in coffee, energy drinks, tea or pills.

Caffeine is a powerful stimulant, and it can be used to improve physical strength and endurance. It is classified as a nootropic because it sensitizes neurons and provides mental stimulation.Habitual caffeine use is also associated with a reduced risk of Alzheimer's, cirrhosis, and liver cancer. So, drink that coffee.

Caffeine’s main mechanism concerns antagonizing adenosine receptors. Adenosine causes sedation and relaxation when it acts upon its receptors, located in the brain. Caffeine prevents this action and causes alertness and wakefulness. This inhibition of adenosine can influence the dopamine, serotonin, acetylcholine, and adrenaline systems.

N-phenethyl dimethylamine 100mg

Eria Jarensis is an orchidaceae alkaloid, meaning it is derived from the orchid family of flowering plants. It is the only known plant derivative to contain N-phenethyl dimethylamine. Phenethylyamines (PEA) Increases levels of epinephrine and norepinephrine that can stimulate beta-adrenergic receptors located on adipose (fat) tissue to release fatty acids into circulation as a fuel source.

However, PEAs effects are relatively short-lived because the compound is broken down by the MAO-B enzyme within hours. N-Phenethyl dimethylamine rectifies that issue so you can realize the thermogenic benefits without having to dose the ingredient every few hours for it to be effective as you would PEA. Therefore, Eria Jarensis has become popular as a supplement for its energy and thermogenic benefits.

1,3-dimethylamylamine - DMAA 60mg

Although seemingly well tolerated in pre-workout supplemental form, DMAA has been linked to a cerebral haemorrhage in a case study with party pill usage.[3]

No long-term toxicity studies are in existence, although acute LD50 of DMAA has been established at 39mg/kg bodyweight intravenous injection and 185mg/kg bodyweight intraperitoneal injection.[4] Theoretically well below what can be achieved via oral ingestion.

A typical starting dose of 1,3-DMAA is in the 10-20mg range and eventually reaching up to 40-60mg a day, there is no actual evidence to support this dosage range but it seems to be the standard dosages range for supplemental 1,3-DMAA on the market.

1,4-dimethylamylamine - DMAA 60mg
This is another form of DMAA, more to follow.

Noopept 60mg

The usual Noopept dosage is around 10 – 30 mg daily.[8] Some people will take a Noopept dose around two to three times daily. Others look for a much bigger Noopept dosage. This is often called a Noopept megadose.

There is one user who has written about his experience on 100 mg Noopept, twice daily. The Noopept megadose didn’t have any negative side effects for him.[9] If you want to use a dosage that is higher than the recommended dosage of 10 – 30 mg, once to three times daily, please read up about it and be careful. We do not advise using a dosage that is higher than normal because of the lack of studied side effects.

 

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