Bulk P-Slin is a powerful glucose-disposal and nutrient-partitioning agent, featuring one of the highest per-gramme concentrations of not only the pentacyclic triterpenoid, corosolic acid, but also bioactive tannins from the Banaba plant. Benefitting from USPowders' unique herbal extraction technology and unmatched value-for-money, Bulk P-Slin was specifically designed to deliver the following benefits, amongst others:
• Incredibly potent concentration not just of corosolic acid but also of highly extracted and profoundly bioactive tannins, both in effective amounts
• Pronounced glucose disposal and nutrient partitioning effects
• Significant improvement in body composition
• Enhanced fat loss and increased muscle-mass-to-fat-mass ratio
• Intense utilization of the anabolic power of food
• Dramatic induction of vascularity and muscle pump
• Improved cellular glucose sensitivity
• No loss in effectiveness during Bulk P-Slin cycle
• Unmistakeable increases in strength, endurance, and recovery, via improved cellular integrity
• Systematic improvement in various metabolic markers
A popular medicinal plant in India, the Philippines, and South East Asia, Banaba (also known Crepe Myrtle or Lagerstroemia speciosa L.) contains bioactive ingredients that include corosolic acid, a pentacyclic triterpenoid agent structurally similar to ursolic acid, as well as tannic acid (or tannins). Tannic acid contains gallotannins as its main components. Besides, another tannin found in Crepe Myrtle is the ellagitannin known as lagerstroemin. One of the most distinctive properties of Bulk P-Slin, in contrast with other corosolic-acid-containing products, is not only that Bulk P-Slin contains one of the highest per-gramme concentrations of corosolic acid ever developed, but also contains highly extracted and profoundly bioactive tannins that combine with corosolic acid to deliver truly potent downstream effects that include glucose-regulation and blood-sugar regulation.
To understand the predominant pathway for the pharmacological activity of Bulk P-Slin, a brief review of the biology of glucose transporter proteins is warranted. A key biochemical pathway for the action of corosolic acid and its related tannins is the glucose transport-4 (GLUT-4) protein gene. Glucose transport proteins shuttle glucose from the blood into cells. A specific glucose transporter protein, GLUT-4, found in skeletal muscle, fat, and cardiac (heart) cells, transports glucose from the blood into these cells. Usually, GLUT-4 resides deep within the cell, but can be translocated to the surface of the cell by insulin, exercise, or by corosolic acid/tannins. The more GLUT-4 cells are recruited to the cell surface, the greater the amount of glucose clearance that occurs. It has been shown in clinical trials that corosolic acid and its related tannins can cause the translocation of GLUT-4 proteins from deep within the cell to the cell membrane to trigger glucose disposal, completely independent of insulin. The consequent reduction in the levels of circulating glucose promotes reduced adipogenesis. Furthermore, in clinical trials, corosolic acid and its related tannins have been shown to down-regulate the expression of PPARg and not only suppressed the expression of pre-adipocytes, but also suppressed the differentiation of pre-adipocytes into mature adipocytes, while stimulating efficient glucose uptake, leading to significantly lower fasting and post-prandial (after-meal) blood glucose levels.
Bulk P-Slin contains highly concentrated tannins extracted from Lagerstroemia speciosa. Tannins play a crucial role in the known pharmacological action of Lagerstroemia speciosa. Corosolic acid induces GLUT-4 translocation in skeletal muscle cells while tannins suppress the expression of these glucose transport proteins in fat cells. Furthermore, Bulk P-Slin contains one of the highest concentrations of corosolic acid per gramme seen in any product around. This is crucial, and is a distinctive feature of Bulk P-Slin, as both corosolic acid and tannins are required to obtain optimal results from Lagerstroemia speciosa.
As already stated, GLUT4 is found in both muscle tissue and adipose cells. Bulk P-Slin, as well as a series of cellular phosphorylations (ranging from the phosphorylation of tyrosine residues and tyrosine kinase activity within cytoplasmic proteins, to insulin receptor substrate activation of phosphatidylinositol-3-kinase, to activation of GTP-binding protein ras, and ultimately to the mitogen-activated protein kinase system (MAPK)) induce several effects, including the translocation of glucose transporter proteins, especially GLUT4, to the cell membrane, leading to glucose uptake, higher glycogen formation, increased activity of the glucose synthase enzyme, activation of transcription factors leading to improved DNA synthesis, and so on. In fact, GLUT4 is one of the only GLUT proteins specifically present in adipose cells.
For those interested, GLUT1, for instance, is found in all tissues, especially in red cells, and in the brain. It is mainly involved in glucose uptake and transport across the blood-brain barrier. GLUT2 is mainly found in the liver, in the gut, in the kidney, and in the B cells of the pancreas, and is involved in the transport of glucose and fructose, as well as in glucose homeostasis, especially in the regulation of the release of insulin. GLUT3 is primarily found in the brain, in the placenta, in the kidney, and in some other tissues. It is involved in glucose uptake in neurons and other tissues. GLUT5 is found in the gut and kidney, and is involved in the absorption of fructose. While GLUT5 is not the only protein that transports fructose, it is the only GLUT protein that transports fructose.Altogether, 14 GLUT proteins have been identified. Only 1-5 have been well characterized. GLUT-4 transport proteins are at the core of glucose disposal. Like GLUT-1, GLUT-2, GLUT-3, and GLUT-5, GLUT-4 is technically a hexose transporter that effectively transports hexose down a concentration gradient. As it turns out, cellular glucose uptake occurs via facilitated diffusion through these so-called hexose transporters.
One of the most powerful supplements for inducing and sustaining true food-induced anabolic activity, Bulk P-Slin contains one of the highest concentrations of Corosolic Acid (and tannins) per gramme around, leading to incredibly profound stimulation of GLUT-4 activation. Given corosolic and tannic acids' key role in GLUT-4 activation and downstream glucose disposal, Bulk P-Slin is especially efficient in shuttling large amounts of glucose to skeletal muscle cells. As a consequence, Bulk P-Slin can be used for meals with relatively high carbohydrate loads (including pre-workout meals). Consequently, it does not come as a surprise that Bulk P-Slin users have reported improved vascularity and pumps, strength and endurance, as well as enhanced recovery. With Bulk P-Slin, food becomes truly anabolic in a primal sense!
Overall, Bulk P-Slin is a USPowders-unique product that boasts effective amounts of highly extracted, super-concentrated pharmaceutical-grade corosolic acid and tannic acid that combine to induce profound glucose-disposal and nutrient-partitioning properties, leading to pronounced improvements in lean mass, enhancements in fat-loss, reduction in circulating blood-glucose levels, as well as improvements in overall metabolic integrity.
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