I did a little resaerch on this at my off time at work. Since DMSO is so great on breaking the skin barrier, it also has the potential of pulling other things in with it. The thing I read about is toxins and other such things that are on the skin but you don't want in the blood sttream. Perhaps this was not the correct place to post this, but I am wondering if anyone has any concern on this. Does cleaning off the surface area before hand help ie. shower, swab of alcohol? Thanks in advance.