is it possible? yes.
is it easy? no.
will it have a reduced negative effect on your liver? most likely not. you just avoid first pass, but it all still gets filtered through the liver. There is no evidence to for or against t/d administration & hepatotoxicity of methylated compounds.
you would most likely get better conversion via t/d admin. but this may even out with less compound delivered.
I really think compounds like hd, m14add, boladrol, ect even though methylated, would be just as good if not better ran transdermally.
I just base this off of using hd transdermally, and finding it as good, if not better than orally.