D-aspartic Acid >> Transdermal ??
- 07-19-2010, 01:08 PM
- 07-19-2010, 01:20 PM
Molecular Weight ??
www biopeptide com/PepCalc/PepMWCalc2.dll/Calculate
Peptide Sequence: D.
D = Aspartic Acid
Would the D- Change the molecular weight significantly ??
I'm not a chemist just love a good transdermal so take it steady.....
- 08-04-2010, 09:14 PM
I'm not sure if a transdermal would be an effective application for DAA. I don't know the exact % of how much DAA is orally bioavailble, but keep in mind that with a transdermal you are only getting somewhere in the realm of 30-40% of the product. Transdermals are better reserved for less orally-active compunds (formestane, resveratrol, etc.). It seems that DAA is active enough orally, so a transdermal would be a waste.
08-09-2010, 08:54 PM
D and L are just referring to optical activity, except in a lab most compounds do not exist in both forms, just one or the other. Seems from all the logs daa works just fine orally. It can be used as a transdermal but I haven't found any studies on an effective dosage when used td. I personally use tcf-1 and it works just fine for me.
08-13-2010, 06:21 PM
What is your reasoning for wanting this to have a transdermal application?
Grab a bottle of TCF-1: Tastes delicious, contains the effective dose of DAA, allows custom accurate dosing, and is on sale at nutra.
08-13-2010, 07:00 PM
The only thing I could see was if oral bioavailability was low it might be worth it cost wise. I'm not sure i've seen studies that show blood levels of DAA x hours after ingestion of DAA though to be able to tell. Still, since its a common amino acid, i tend to doubt it has bad bioavailability.
08-17-2010, 12:01 PM
08-17-2010, 12:36 PM
Sorry about late response but have been on holiday. Just received 80 grams DAA in the post today.
Chequamegon: Thanks for the info - I just liked the sound of a little Form/DAA in a bottle of penetrate as it would be easier to combine and apply.
HATEFULone: I wonder what the % adsorption of DAA is in a transdermal ?? There must be some difference in the two methods as it would not have been through the digestive system ??
Perhaps I'll give it a try and let you know how it works out and the dosages used ;0)...
HereToStudy: I wrote the question to promote a little discussion. I went with the bulk because of the low dosages in the TCF-1, although I'm now aware that your getting 24 doses and the price has come down...Good Show !!!
EasyEJL: I believe that DAA is stored in the testes perhaps a little DAA in penetrate rubbed directly in the area may add a little to the efficacy of the DAA.
Been doing a little reading around and have seen that DAA has oestrogen promoting side-effect and also raises anxiety in others perhaps a different method of delivery allowing a lower dose to be effective may make a little difference.
Little busy this week but I may add a little DAA to some penetrate next week and see how it goes...
Thanks for your help and please feedback anything that may further this discussion
08-19-2010, 03:37 AM
What's oral BA of DAA? I would be inclined to think that with a transdermal you could hope for maybe 30% BA. Seeing as how you still need multi gram dosages it's not feasible. Also DAA's lipophilic/hydrophilic balance does not appear to be ideal for a transdermal. I',m basing this off aspartic acid so I'm not sure how the optical orientation would effect figures.
08-26-2010, 02:00 AM
id mice mine in my ASGT pre-WO for a good kick, then drink it with water in the other doses of the day.
08-27-2010, 09:35 AM
Rahhh, do you mix bulk daa or your tcf-1 with asgt? And is there any difference in just plane asgt vs asgt pluss daa?
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