- 09-17-2008, 08:55 AM
Been doing a little research on res. Turns out that it has a molecular weight of 228.25 and is readily dissolved in DMSO and ethenol and other organic solvents. This just sounds too perfect for a transdermal! With its poor oral bioavailibility, TD would seem to make a lot more sense.
Anyone have any input on what concentration to make? Or how would one tell if it was really working or not.
I have everything I need to try this. I'm thinking 6grams of Res dissolved in approx. 10ml DMSO then add penetrate to bring the final volume to 120ml. This would give 50mg/ml concentration. Could always take it to 100mg/ml.
- 09-17-2008, 09:06 AM
Hmm that would be nice. I have some penetrate and still lots of TRez, sounds like it should have been done already though if this were the case.
- 09-17-2008, 09:08 AM
09-17-2008, 03:33 PM
I don't know much about transdermals but I think Sustain Alpha by Primordial contains it. Here's a quote from Nutra's product description:
"Sustain Alpha utilizes a blend of 99% pure Resveratrol, 7,8 Benzoflavone, and a combination of lightweight volatile oils to create a synergistic surge in LH & FSH for increased Testosterone production."
09-17-2008, 03:42 PM
09-17-2008, 10:23 PM
Another thing, wold penetrate work? I do not remember what type of carrier it is. I have only made 1 homemade transdermal and it was for acne and it was very successful.
09-17-2008, 10:36 PM
Penetrate should work fine. I am going to dissolve it in DMSO first though then add that to the penetrate. Still looking for a good price on the 99% stuff before I give up and use the 50% res.
01-10-2009, 11:00 PM
01-11-2009, 12:17 PM
Not yet. Couldn't find the pharmaceutical grade for a decent price, but I did pick up some 50% bulk that I'm going to try. I'm just not sure how to judge its effectiveness. If I take it orally, I assume through data that I have read that it is doing what resveritol does. How would I know if it is doing its thing transdermally?
01-13-2009, 10:47 PM
02-04-2009, 11:59 PM
02-05-2009, 02:25 PM
I've got 12g of 98% res I kept planning to do this with, but keep forgetting
03-04-2009, 07:54 PM
03-04-2009, 11:15 PM
03-05-2009, 08:11 AM
03-15-2009, 10:08 AM
Check this out on Wikipedia. (I couldn't post the link)
"The most efficient way of administering resveratrol in humans appears to be buccal delivery, that is without swallowing, by direct absorption through the inside of the mouth. When one mg of resveratrol in 50 mL solution was retained in the mouth for one min before swallowing, 37 ng/ml of free resveratrol were measured in plasma two minutes later. This level of unchanged resveratrol in blood can only be achieved with 250 mg of resveratrol taken in a pill form."
"About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolized in intestines and liver into conjugated forms: glucuronate and sulfonate. Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose. Even when a very large dose of resveratrol (2.5 and 5 g) was given as an uncoated pill, the concentration of resveratrol in blood failed to reach the level necessary for the systemic cancer prevention. However, resveratrol given in a proprietary formulation SRT-501 (3 or 5 g), developed by Sirtris Pharmaceuticals, reached 5-8 times higher blood levels. These levels did approach the concentration necessary to exert the effects shown in animal models and in vitro experiments."
"According to Patrick Arnold, it also significantly increases natural testosterone production from being both a selective estrogen receptor modulator and an aromatase inhibitor."
I am going to try a sublingual formula using 40% Distilled water, 30% 100 Proof Vodka, and 30% Propylene Glycol as a Penetration Enhancer. With this level of efficacy the Resveratrol would be quite affordable.
03-15-2009, 11:47 AM
03-15-2009, 06:29 PM
03-15-2009, 07:08 PM
03-15-2009, 07:32 PM
03-15-2009, 10:08 PM
03-15-2009, 11:57 PM
03-16-2009, 12:07 AM
03-16-2009, 12:17 AM
03-16-2009, 07:50 AM
03-16-2009, 10:10 AM
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03-16-2009, 07:20 PM