My weakest points from a pure muscle/appearance standpoint are calves and upper chest.
Calves are in great condition -- but don't have all that much girth to them lol. But I can live with it.
Upper chest isn't terrible, but I just have a miserable time focusing on it. Whenever I do incline, my front delts want to take over. So I try to vary things as much as possible to keep the focus/tension on the upper pec, but sometimes it just doesn't get all that much.
And the thing that pains me (not physical pain, but just makes me sad lol) the most is I have a hip imbalance. Because of that, my left shoulder looks like it's slightly rolled forward. It's a total nightmare with any arm work (including bench and presses) because I have to try really hard to draw that left shoulder and shoulderblade back to keep it tucked and have pressure go where it's meant to. But most importantly, when I drop down into a squat or a crouch (I was a catcher in baseball for years when I was younger), my quads aren't parallel -- one is even with the ground and the other isn't. So I do as much solo leg work as I can and when I do outright squats, I can't go as heavy as I used to because it's unevenly distributed and I'll blow out a knee or a hammy.
Pretty sure it goes back to when I blew a hamstring out playing slow pitch softball (of all things...) a little over 5 years ago. Sad, because I weighed less and was squatting, benching, etc. significantly more than I do now.