Everyone is different. I run usually 3-4 months and take a week off. Sometimes less, sometimes more. Technically speaking, if your supps are on point, you wouldn't have to but I feel it gives me a re charge mentally. Just came off taking my 7 days off.... Stuck to my same diet/supplement regimen and when I hit chest yesterday, literally every lift I hit was a PR. More weight and more reps. It's like a job and people/ your body, need a break once in awhile.