Carbohydrates on GH / Protein synthesis

justinmonty

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Here is an interesting study I found, It may suggest that eating protein,carbs seperate from eachother may be the best way to go:

Response of plasma insulin and Growth Hormone to carbohydrate and protein feeding
Johanna A. Pallottaand Patricia J. Kennedy
Radioisotope Service, Veterans Administration Hospital, Bronx, N.Y., USA


Received 5 February 1968.
Available online 24 February 2004.


Abstract

Twelve male patients were fed diets of glucose, protein, starch and combinations of protein with either glucose or starch. Protein was a weak stimulus to insulin production compared to carbohydrate, which is a powerful insulin secretagogue. Combination feedings led to a synergistic effect on insulin secretion. Protein caused a greater plasma insulin response in the two patients with maturity-onset diabetes than it did in non-diabetic subjects. Protein feeding led to a rise in plasma HGH at the 2nd to the 4th hour. After glucose or starch there was a rise in plasma HGH at the 4th–5th hour following an initial suppression. HGH responses were blunted when combinations of carbohydrate and protein were fed. These interrelationships are discussed.
furthermore this was taken from layne nortons article on broscience forum where he states:

I therefore suggest that one consume 4-6 larger protein doses per day instead of 6-8 meals and wait 4-5 hours between meals rather than 2-3 hours.


At the moment, there is no clear way to overcome the refractory response. However, there is evidence that supplementing with free form amino acids with carbohydrates between meals may improve protein synthesis compared to normal meals alone8.

It is possible that a free form amino acid supplement could spike plasma levels of amino acids to a far greater level than can be achieved with whole foods and perhaps this supraphysiological response is enough to overcome the refractory response. It is also possible that the carbohydrates in the supplement have an effect.

The insulin time course in the experiment we performed lasted 3 hours, the same as protein synthesis. Additionally, Wolfe et al. also showed that the timecourse of insulin seemed to track protein synthesis during an essential amino acid infusion5. Perhaps maintaining elevated plasma insulin levels is required to prolong protein synthesis in response to a meal. In either case, it appears that supplementing with an amino acid supplement containing ~2-3g of leucine along with some carbohydrates (~20-30g) is an effective way to maximize muscle protein synthesis.
 

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