Gamma oryzanol is a mixture of substances derived from rice bran oil, including sterols and ferulic acid. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol. However, there is no meaningful evidence supporting the use of gamma oryzanol for any of these purposes.
Scientific names: “Oz,” gamma-orizanol, caclate, gammajust 50, gamma-oz, gammariza, gammatsul, guntrin, hi-z, maspiron, oliver, oryvita, oryzaal, thiaminogen
Common names: Gamma oryzanol also is known as rice bran oil.
Safety rating: No safety concerns despite wide use.
What is Gamma Oryzanol?
Gamma oryzanol is a mixture of ferulic acid esters of sterols and triterpene alcohols, extracted from rice bran oil and other grain oils such as corn and barley. Ferulic acid compounds also are present in many foods, including oats, berries, citrus fruits, tomatoes, olives, and vegetables. Gamma oryzanol serves as an important antioxidant within plant cells.
What is Gamma Oryzanol used for?
Early reports from the mid-1950s reported , extraction, and purification of gamma oryzanol. However, the Japanese have been using it as a medicine since 1962. It first was used to treat anxiety. In the 1970s it was found to be an effective treatment for menopause. Gamma oryzanol therapy was approved to treat elevated cholesterol and triglyceride levels in the late 1980s.
Gamma oryzanol has been proven effective to treat symptoms of menopause, such as hot flashes and aging syndromes. One report found a 50% reduction of menopausal symptoms in about 70% of patients. The proposed mechanisms of action are the reduction in secretion of leutinizing hormone by the pituitary gland and promotion of endorphin release by the hypothalamus. The overall importance of these effects has not been fully determined. More human clinical trials are needed.
Human studies using gamma oryganol for hyperlipidemias also are promising. Reduced total cholesterol and triglyceride levels, and increased HDL levels were noted in hyperlipidemic patients given gamma oryzanol.
Gamma oryzanol has been used to treat GI problems. The mechanisms by which gamma oryzanol exerts its effects appear to be the normalizaton of nervous system control of digestive secretion.
Gamma oryzanol also is used as a supplement in bodybuilding, but few well controlled human trials exist indicating any benefits.
Gamma oryzanol's effects on the CNS and endocrine system have been sporadically reported. Animal studies show that gamma oryzanol increases brain norepinephrine content. In humans, gamma oryzanol inhibits TSH levels in patients with hypothyroidism, possibly by a direct action at the hypothalamus. The overall importance of these effects requires more clinical trials.
I went to the web page. The main warning sign was the claims. If a otc suppliment claims to raise your test by 800%, you better think twice before plopping down $80 for this stuff.
HAHAHAHAHAHAHA"What started in 2005 as an innovative product development plan with a goal to develop a functionally superior free-testosterone elevating product has resulted in the supplement breakthrough of the ages—ARIMATEST. A recent ZRT trial documented increases in free testosterone of up to 12,149%. Yes, you read right. That’s 12,149%. While other supplements are bragging about 200%, 300% and the closest competitor brags about 600% increases—ARIMATEST at 12,149% blows them away.
the Vitamin Shoppe has 200 60 mg caps for $15.