Does Forskolin/Forslean help to increase Test or Free Test?
- 10-12-2007, 11:54 AM
Does Forskolin/Forslean help to increase Test or Free Test?
I did the search and read several logs on the compound but there was no clear answer.
I know its great for body recomp from the many comments. The gastro effects might be due to a somewhat cleansing function of the colon???
Anyway I am just wondering if in some way it does increase test?
Would be a nice addition to a stack I am dreaming up.. with tidbits here and there.
- 10-12-2007, 12:00 PM
10-12-2007, 12:03 PM
10-12-2007, 12:06 PM
10-12-2007, 12:09 PM
I'll have to look into Drive when I finish my current regimen and take a break.
it seems to be a nice piece of work.
10-12-2007, 12:15 PM
I am going to minimize all the dosages and cap so I can have my own little mix... might add in forslean/forskolin... do not know about icariin yet because other parts might mimic its usability....
and maybe some beta alanine / cissus/ turk for endurance, bone strength and muscle strength
that will probably be it though...
I already have a natural formula with the cordyceps and reishii and stuff like that...
basically writing ideas now until I get ready to put it into effect.
10-12-2007, 12:16 PM
10-12-2007, 12:23 PM
Just trying to get a nice cross section of a lot of beneficial herbals.
stuff I can cycle on an off into old age and it stil be helpful.
10-12-2007, 05:27 PM
10-13-2007, 07:23 AM
10-13-2007, 10:40 AM
Great Stack you got going there bud. Now only if you could find some dodder seed and safed musli in bulk you would have the ultimate NHA stack. However, I assume you have done some reading on coleus forskolin, but I figured I would mention that you would certainly want to add it to your stack. The main benefit of adding it to the stack is that it works as an amplifier/second messenger. In other words, while the stack your creating will boost your testosterone the forskolin will actually take that extra test and do something with it more or less. I have plenty of resources on this, but not enough time to go into depth and list them. Lanbane already dropped you that link on Drive, which gives you a good scientific in-depth look at forskolin/forslean. Anyway, good luck and good home brewing there bud. Note: You should post up some results when you figure out your stack and how you'll be dosing everything...I'm curious.
"Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
10-13-2007, 11:38 PM
Forslean increases cAMP, which increases hormones in the body. This was a problem for me because it irritated my existing gyno. Itchy chest, and tender nipples. I also noticed that if you dont burn the fat off that forslean draws out of the stores then it is rediposited. I didnt do cardio while on Forslean but continued to lift regularly, and noticed an increase of abdominal, and chest fat, but other areas of the body looked leaner. This stuff is for an individual who is dedicated to cardio on a regular basis in my opinion.
10-14-2007, 12:38 AM
I'm too lazy to look it up right now, but Bobo has posted some VERY in-depth writings about the anabolic/anti-catabolic effects of forskolin. Look it up so my lazy ass doesn't have to
10-14-2007, 01:10 AM
10-14-2007, 10:26 AM
You must spread some Reputation around before giving it to rpen22 again.
10-14-2007, 09:24 PM
10-14-2007, 09:45 PM
10-14-2007, 10:02 PM
Inhibitory effects of superoxide dismutase and cyclic guanosine 3',5'- monophosphate on estrogen production in cultured rat granulosa cells
PS LaPolt and LS Hong
Department of Obstetrics and Gynecology, University of California School of Medicine, Los Angeles 90095-1740, USA.
Superoxide dismutases (SOD) modulate oxygen free radical metabolism and influence second messenger signaling in a variety of cell types. We have investigated the influence and possible mechanisms of action of SOD on aromatase activity in cultured rat granulosa cells. Although treatment of granulosa cells with FSH (0.3-30 ng/ml) resulted in a dose- dependent stimulation of estrogen levels, cotreatment of cells with SOD (10(-6) M) significantly attenuated estrogen production at the highest doses of FSH. The effects of SOD were dose dependent between 10(-7)-10(- 5) M, with increasing amounts of SOD causing decreasing concentrations of estrogen. Cotreatment of cells with catalase (1500 U/ml) failed to prevent the inhibitory influence of SOD on estrogen production, indicating that the effects of SOD were not due to accumulation of hydrogen peroxide. Although incubation with either forskolin or (Bu)2cAMP alone stimulated estrogen production from granulosa cells, cotreatment with SOD significantly attenuated estrogen levels, indicating that SOD can inhibit aromatase activity at one or more post- FSH receptor sites. Treatment of cells with SOD, FSH, or forskolin resulted in small, but significant, increase in cGMP concentrations. In contrast, cotreatment of cells with FSH plus SOD as well as forskolin plus SOD had a marked synergistic effect on cGMP content, increasing cGMP levels over 100-fold. Incubation of granulosa cells with (Bu)2cGMP (2 mM) significantly decreased FSH-induced estrogen levels in a dose- dependent manner (0.25-2 mM). In addition, (Bu)2cGMP attenuated both forskolin- and (Bu)2cAMP-induced estrogen production. In contrast to the effects of (Bu)2cGMP and SOD on estradiol levels, these agents had no significant effect on progesterone production by cultured granulosa cells. These results demonstrate attenuated induction of aromatase activity by FSH in cultured rat granulosa cells cotreated with SOD, suggesting a potential modulatory role of this antioxidant on granulosa cell functions. The findings that SOD and activators of the cAMP- dependent signaling pathway synergistically increase the levels of the second messenger cGMP and that (Bu)2cGMP treatment attenuates FSH-, forskolin-, and cAMP-induced aromatase activity suggest a potential mechanism of SOD action and demonstrate the antagonist action of cGMP on cAMP-mediated estrogen production.
10-14-2007, 10:04 PM
Inhibitory effects of nitric oxide on estrogen production and cAMP levels in rat granulosa cell cultures
RS Ishimaru, K Leung, L Hong, and PS LaPolt
Previous studies demonstrated inhibitory effects of nitric oxide (NO) and cGMP on ovarian steroidogenesis. This study examined the effects of NO on estrogen levels and cAMP accumulation from immature cultured rat granulosa cells. Granulosa cells were incubated with media alone (control), FSH or FSH plus increasing concentrations of the NO generator, (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA/NO). While FSH increased estrogen levels 15-fold compared with controls, DETA/NO inhibited FSH-stimulated aromatase activity in a dose-dependent manner. Time-course studies revealed that the inhibitory effects of DETA/NO on aromatase activity persisted throughout the 72 h culture period. Treatment with DETA/NO also inhibited the stimulatory effects of forskolin on estrogen production, indicating that NO can influence steroidogenesis by actions downstream of the FSH receptor. Incubation of cells with FSH plus DETA/NO increased cGMP accumulation over 100-fold, compared with cells treated with media or FSH alone. In this regard, a cGMP analog mimicked the inhibitory effects of NO on FSH- and forskolin-stimulated estrogen production, indicating a potential mechanism of NO action. NO also decreased FSH-stimulated (cAMP) accumulation from cultured cells, indicating an antagonistic effect of NO on the second messenger mediating FSH actions. These findings demonstrate that NO inhibits estrogen production from rat granulosa cells, potentially reflecting actions on the second messengers cGMP and cAMP.
10-14-2007, 10:14 PM
10-14-2007, 10:19 PM
10-14-2007, 10:55 PM
10-14-2007, 11:00 PM
10-15-2007, 01:17 PM
10-15-2007, 01:19 PM
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