Very nice, just a few questions tho
Why are all the ingredients just their common name instead of something cooler sounding?
35%? that sounds high, but not impossible. For some reason I had always assumed 5-10%
Damn, don't take drive with Aspire36. Oh wait, I already have
That also explains a few things.
And dodder seed "Effects of semen Cuscutae, rhizoma Curculiginis, radix Morindae officinalis on human spermatozoan's motility and membrane function in vitro" - CONCLUSIONS: Semen Cuscutae decoction is an effective promoting preparation for sperm motility and the membrane function stabilized. Therefore, Semen Cuscutae may be beneficial in treating male sterility and may raise success rate in artificial insemination.
Can I sue AN for child support for my wife being pregnant now?
Here ya go
...
Ther Drug Monit. 2001 Feb;23(1):21-6. Links
Determination of sildenafil citrate in plasma by high-performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate.Lee M, Min DI.
Division of Clinical and Administrative Pharmacy, College of Pharmacy, The University of lowa, Iowa City 52242, USA.
This study was designed to establish a simple and reliable assay method that could be routinely used in the clinical laboratory setting using liquid extraction and high-performance liquid chromatography (HPLC). In addition, a case of potential interaction of grapefruit juice with sildenafil citrate is presented. The peaks of sildenafil (measured as sildenafil salt) and internal standard were identified with an ultraviolet detector at 230 nm and detection limit at 10 ng/mL. In a single elderly male patient, grapefruit juice increased the Cmax of sildenafil by 42% (1067.7 ng/mL to 1517.0 ng/mL) although AUC was not significantly altered (4082.9 ng x h/mL to 4171.9 ng x h/mL) by grapefruit juice. Sildenafil could be determined in a simple and reliable method using HPLC with liquid extraction. This case indicated that grapefruit juice might increase the Cmax of sildenafil without significant change in AUC. A further study with an appropriate number of subjects is needed before determining the degree of interaction between grapefruit juice and sildenafil.
Clin Pharmacol Ther. 2002 Jan;71(1):21-9. Links
Comment in:
Clin Pharmacol Ther. 2005 Oct;78(4):441-3.
Effects of grapefruit juice on the pharmacokinetics of sildenafil.Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, Hering U, Bulitta J, Schreiner P, Sörgel F, Fuhr U.
Institute for Pharmacology, Clinical Pharmacology, University of Köln, Germany.
[email protected]
BACKGROUND AND OBJECTIVES: Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N -desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this study we investigated the influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N -desmethylsildenafil. METHODS: In a randomized crossover study, 24 healthy white male volunteers received single 50-mg doses of sildenafil. Two doses each of 250 ml grapefruit juice or water, respectively, were administered 1 hour before and together with the drug. Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). RESULTS: Grapefruit juice changed the area under the sildenafil plasma concentration-time curve from time zero to infinity [AUC(0-infinity) from 620 [1.53] ng/ml x h to 761 [1.58] ng/ml x h (geometric mean with geometric standard deviation), corresponding to a 23% increase (90% confidence interval, 13%-33%). N-Desmethyl sildenafil AUC(0-infinity) increased by 24% (90% confidence interval, 17%-32%). Maximum plasma concentrations (C(max)) of sildenafil and N -desmethylsildenafil were essentially unchanged. There was a trend toward a prolonged time to reach C(max) during the grapefruit juice period (from a median of 0.75 hour to a median of 1.13 hours), corresponding to an increase by 0.25 hour (90% confidence interval, 0-0.63 hour). Interindividual variability was pronounced in both periods. CONCLUSIONS: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.
As for the ingredients- we prefer the KISS principle- and I give special thanks to ALL of the testers for this product- you guys made this blend happen- the product speaks for itself, w/o any "sexy" ingredients
I started with one simple hypothesis for DRIVE: that a number of novel herbal compounds commonly used in many supplements can be used in a synergistic manner to create a compound that delivers steroid-like results, w/o HPTA shutdown. I had several ideas, and you guys helped narrow it down into the finished product- I took all the subjective data from the testers, put it in a spreadsheet, and looked at the components and how they seemed to effect users at each given dosage....blood tests probably would have been better- but I don't have a reliable source to carry them out.
And yes, some of the components in DRIVE will actually increase spermatogenesis....
