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You testers know Drive works, period- but how?
What is one of the mechanisms through which Drive increases anabolism? Here is a sneak preview
cAMP is classified as a second messenger, meaning that it exerts its effects by acting in a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, another secondary (hence “second” messenger) pathway is activated that increases cAMP production. Increased cAMP production is responsible for the activation of protein kinase A- an enzyme that has some positive effects androgen receptor (AR) binding even in the absence of other androgens. cAMP also is a signal for steroidogenesis (testosterone production) in the Leydig cells of the testes, accomplishing this action by increasing levels of StAR (steroidogenic acute regulatory protein). StAR is noteworthy, because it is a Leydig cell cholesterol transfer protein, and testosterone is synthesized from cholesterol.
Therefore, StAR activation is necessary, because it stimulates enzymes involved in the transfer of cholesterol to testosterone. By increasing the intermediate between these two processes, a resulting positive shift in anabolism can occur. High cAMP levels also equate to high levels of luteinizing hormone (the hormone responsible for mediating endogenous spermatogenesis), and when cAMP levels are elevated (Drive causes a marked elevation of cAMP), it serves as an intermediate in the signaling cascade that ranges from LH binding to testosterone production, resulting in marked increases in anabolism and protein synthesis. Numerous other studies have shown parallels between increased cAMP levels and increased anabolism, and a ground-breaking 2005 study found that men taking one of the main components in Drive (and at roughly the same amount of this compound included in the daily dosage of Drive) significantly increased free testosterone levels, lowered body fat levels, and increased lean mass (an average of 3.5 kg.!!!). Another 2001 study also yielded similar results!! These findings are extremely promising, for another important reason: when an athlete uses anabolics for any length of time, impairment of the HPTA (hypothalamo-pituitary gonadal axis, the entity responsible for endogenous testosterone production) tends to occur. This is important, because when HPTA shutdown occurs, it cripples (albeit temporarily) the ability of the athlete to synthesize testosterone endogenously. A large part of HPTA shutdown is due to decreased cAMP levels and LH levels, and Drive increases both of these. By upping cAMP and LH post-cycle, it allows the body to resume testosterone production safely, and even to greatly surpass pre-cycle baseline levels!!! It is also notable to mention that Drive also has some effects on the androgen receptor, and may exert some positive anabolic effects through this channel as well, but has not been shown to effect the HPTA.
Keep Drive in mind for your next PCT, to stack with RPM, or simply to use as a stand alone anabolic- you will be happy that you did
More to come later this week:woohoo:
What is one of the mechanisms through which Drive increases anabolism? Here is a sneak preview
cAMP is classified as a second messenger, meaning that it exerts its effects by acting in a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, another secondary (hence “second” messenger) pathway is activated that increases cAMP production. Increased cAMP production is responsible for the activation of protein kinase A- an enzyme that has some positive effects androgen receptor (AR) binding even in the absence of other androgens. cAMP also is a signal for steroidogenesis (testosterone production) in the Leydig cells of the testes, accomplishing this action by increasing levels of StAR (steroidogenic acute regulatory protein). StAR is noteworthy, because it is a Leydig cell cholesterol transfer protein, and testosterone is synthesized from cholesterol.
Therefore, StAR activation is necessary, because it stimulates enzymes involved in the transfer of cholesterol to testosterone. By increasing the intermediate between these two processes, a resulting positive shift in anabolism can occur. High cAMP levels also equate to high levels of luteinizing hormone (the hormone responsible for mediating endogenous spermatogenesis), and when cAMP levels are elevated (Drive causes a marked elevation of cAMP), it serves as an intermediate in the signaling cascade that ranges from LH binding to testosterone production, resulting in marked increases in anabolism and protein synthesis. Numerous other studies have shown parallels between increased cAMP levels and increased anabolism, and a ground-breaking 2005 study found that men taking one of the main components in Drive (and at roughly the same amount of this compound included in the daily dosage of Drive) significantly increased free testosterone levels, lowered body fat levels, and increased lean mass (an average of 3.5 kg.!!!). Another 2001 study also yielded similar results!! These findings are extremely promising, for another important reason: when an athlete uses anabolics for any length of time, impairment of the HPTA (hypothalamo-pituitary gonadal axis, the entity responsible for endogenous testosterone production) tends to occur. This is important, because when HPTA shutdown occurs, it cripples (albeit temporarily) the ability of the athlete to synthesize testosterone endogenously. A large part of HPTA shutdown is due to decreased cAMP levels and LH levels, and Drive increases both of these. By upping cAMP and LH post-cycle, it allows the body to resume testosterone production safely, and even to greatly surpass pre-cycle baseline levels!!! It is also notable to mention that Drive also has some effects on the androgen receptor, and may exert some positive anabolic effects through this channel as well, but has not been shown to effect the HPTA.
Keep Drive in mind for your next PCT, to stack with RPM, or simply to use as a stand alone anabolic- you will be happy that you did
More to come later this week
:woohoo:
