I was looking a little more closely to the supplement fact on this and I noticed 1 scoop of NO Explode has 25mg of vitamin B6. This might not sound bad a first until you realize that high dosages of B6 can cause nerve damage!! And it takes about 3scoops for No Explode to work and if you do that every time you workout then that equals a lot of B6 and thats not counting the B6 that you get from natural sources!