For Your Viewing Pleasure, The Detailed RPM Write-up
- 04-20-2007, 04:39 PM
For Your Viewing Pleasure, The Detailed RPM Write-up
Goal. We all have them. But what truly is a goal. Webster dictionary defines goal as:
1. The end toward which effort is directed
2. The terminal point of a race.
When we think of our goals we think of how quickly can we accomplish them. Whether your goal is losing a few pounds, increasing performance, or bursting through a new plateau, we all want to race to the finish line. Unfortunately, we all have lives and sometimes life gets in the way and knocks us out of the race. We seek out products that make claims that will help us reach our goals and reach them quickly. However, we find only once again we have lost our hard earned dollars and have become no closer to the finish line. Well, not anymore!
Applied Nutriceuticals has the answer to putting you back in the drivers seat and racing towards your goal at speeds you never thought possible! Finally there is a product that makes every day…..Race Day! That product is from Applied Nutriceuticals. What is RPM? Rpm is an exclusive formula that provides explosive energy, crisp uncanny mental focus, noticeable strength increases, all while giving you insane pumps, suppressed estrogen, increased testosterone, while incinerating fat!!!! RPM is instant gratification from the very first dose! RPM is in its own race class!
Lets look under the hood at this super-charged formula………………
RPM’s formula is so unique it requires it’s own class. RPM, the supplement world’s first Anabolic-Cognitive Energy System Enhancer (A-CESE), where anabolics meet cognitive psy-stimulants!
How do A-CESEs differ from other product categories on the market? An A-CESE is a product that contains testosterone-like, anti-catabolic, and aromatase-inhibiting properties, while at the same time delivering optimal mind/muscle connection/contraction through unique peripheral vasostimulatory perfusion and increased cognitive psycho-motor control. RPM combines P-SARM Synthase AI- a unique blend of research-grade icariin, Arginine , Naringenin, and oligomeric proanthocyanidins (OPC’s), and Methyl-AMP Complex, a powerful blend of methyl-xanthine caffeine and chocamine.
AN uses the highest quality ingredients in scientifically-proven doses to achieve maximal results!! In the product constituent P-SARM Synthase AI, RPM utilizes pharmaceutical-grade Icariin, a potent vasodilator with anabolic and anti-catabolic effects, that can also yield stronger, more forceful muscle contractions!! Icariin works through several different mechanisms: by increasing nitric oxide (NO) through PDE5 inhibition, by acting as a potent anti-catabolic agent that increases the testosterone to cortisol ratio, by increasing muscle contractility by deactivating AchE (Acetycholinesterase), and by boosting endogenous testosterone levels through increasing cAMP and luteinizing hormone and decreasing prolactin. It also is considered a Phytochemical Selective Androgen Receptor Modulator or P-SARM. A P-SARM is a phytochemical (plant-derived) compound that mimics the effects of androgens on , strength, bone growth, drive, and sexual function, while at the same time not negatively effecting blood lipids or blood pressure. P-SARMs provide an excellent alternative to other “enhancement” products on the market, including oral bioavailability, biochemical structure, and lack of steroid-related side-effects!!!
As mentioned before, Icariin has potent anti-catabolic effects, along with testosterone-mimicking and muscle-contraction-enhancing benefits - several studies have shown that it actually competes with glucocorticoids for receptor sites in a manner similar to testosterone, while at the same time improving the testosterone to cortisol ratio. This is caused by two different mechanisms of action: the aforementioned competition with glucocorticoids, and also increased testosterone production, through increased cAMP (cyclic AMP, a second messenger important in hormone signaling) levels, luteininzing hormone (LH) levels, the actual mimicry of testosterone in spermatogenesis, and decreased prolactin levels. Icariin seems to block glucorticoids from binding to cortisol receptors, thus blocking the action of cortisol. This alone will cause an anabolic effect by positively skewing the T:C ratio, which is a trigger for greater protein synthesis, increased aggression towards the iron, and insane muscle contractions!!
RPM also reduces aromatase and estradiol, allowing for the greater production of T as a substrate for aromatase activity- as users of RPM report huge rises in strength, physique hardness, and positive aggression while using this compound, an effect that can be at least partially attributed to the androgen-mimicking qualities of Icariin. RPM also has a dopaminergic effect, allowing for increased dopamine levels and decreased prolactin levels, both of which are triggers for increased testosterone. Also, icariin can enhance muscle contraction by decreasing the effects of acetylcholinesterase (AChE). Acetylcholine (Ach) is a neurotransmitter necessary for muscle contraction, and AChE is responsible for disabling ACh at the neuromuscular junction. Icarin actually blocks this disabling action, allowing for ACh to stay at the synapse, and better exert its effects, for a longer period of time- allowing for harder and stronger muscle contractions!!!
Icariin is a selective inhibitor of cyclic guanosine monophosphate (cGMP)- specific phosphodiasterase type 5 (PDE5 for the purposes of this article). This is important, because PDE5 hydrolyze cGMP into an inactive molecule. cGMP is important because nitric oxide (NO) requires cGMP to moderate vascular control and vasodilation. So, essentially, no cGMP, no vasodilation (the “PUMP”), because NO requires cGMP to work. The more cGMP, the more NO-induced vasodilation- therefore greater pumps!! Icariin stops PDE5 from disabling cGMP and allowing cGMP to extend its activity, which exerting the effects of NO in skeletal muscle, allowing for a stronger muscle contraction and pump. Viagra is probably the most well known PDE5 inhibitor on the market- but how does Icariin compare? In scientific studies, pure icariin has been found to have roughly one-tenth the PDE5 inhibitory activity and nitric oxide productivity of Viagra- and in P-SARM Synthase AI, the dosage is tailored appropriately to reflect these findings!! In short, the PDE5 inhibition displayed by icariin puts RPM in a class above all other NO enhancers- the effects can actually be viewed as “pharmaceutical-like!!!!”
The inclusion of oligomeric proanthocyanidins (OPCs) are also essential in the creation of any good A-CESE, because OPCs contain their own combination of unique and effective constituents, which allows P-SARM Synthase AI to exert potent anti-aromatase (AI), anti-oxidant, and vasodilatory effects. OPCs have been shown in numerous studies to have the ability to block the conversion of androgens to estrogens, with a potency comparable to several widely marketed pharmaceutical AI inhibitors (Arimidex). RPM reduces aromatase activity and estradiol as well, allowing for more testosterone (T) to be produced!!
Compounds exhibiting AI characteristics also reduce SHBG (steroid hormone binding globulin) as well. This is important, because this allows for a drastic increase in free testosterone (T). When this occurs, coupled with T levels that are already high from decreased aromatization of estrogen, WATCH OUT!!!! Look for longer, harder more workouts, rapid strength increases with personal records on all your lifts, greater protein synthesis, quicker recovery, while also allowing for increased lipolysis (fat burning)!! This, coupled with the androgen-mimicking qualities of the P-SARM Icariin, gives the product a unique “hardness” enhancing quality, giving the user of the product an “eye” popping type of physique that looks to be cut from stone!!!
OPCs also protect against free radicals and subsequent DNA and oxidative damage, qualities that are extremely important to the hard-training athlete. Oxidative damage is a common occurrence during stress and hard training, and it can stop lean body mass gains in their tracks!! Less oxidative damage, better recovery, giving you the ability to train longer and harder!!! The nitric oxide-enhancing, vasodilatory properties of OPCs have also been documented in countless studies. The flavonoids contained in OPCs actually increase levels of Nitric Oxide Synthase (NOS), the enzyme that allows for the conversion of arginine to nitric oxide. This is very important, as nitric oxide synthase competes with arginase for the utilization of the amino acid . Arginase converts L-arginine into ornthine, and increased arginase and ornthine activity, are counteractive to the nitric oxide production pathway. By increasing NOS, the flavonoids in OPCs “crowd out” arginase, allowing for more arginine to be processed into NO. The result is higher NO levels, even greater vasodilation, and gigantic pumps and a physique hard as nails!!
Naringin, and its novel component Naringenin, also exert extensive effects within the P-SARM Synthase AI complex. Naringin (and Naringenin) exhibit remarkable aromatase and estrogen-inhibiting properties by decreasing the cytochrome P450arom isoform, an enzyme that also allows for the oxidative metabolism for chemical modification and degradation of oral medications. This can have very positive effects on the T:E ratio, and the combination of OPCs and Naringenin can be potentially additive or synergistic in eliminating estrogen, and allowing for more circulating free testosterone and all of its benefits!!! Naringin and Naringenin have also been shown to have profound effects on the metabolism of caffeine and PDE5 inhibitors such as Icariin, allowing for these compounds to be much more effective on a per dose basis- by up to 35%!!!
L-Arginine is also an essential component of the P-SARM Synthase AI . L-Arginine is an amino acid that is necessary for cell division, the healing of wounds, displacing ammonia from the body, the release of hormones, and immune function. Most importantly, L-arginine is necessary for the production of Nitric Oxide (NO, as mentioned above), a messenger gas responsible for the promotion of blood vessel relaxation (“pump”), and the regulation of vascular tone. NO is derived from arginine and oxygen via Nitric Oxide synthase (NOS), and, as mentioned above, NO exerts its effects on tissue through cGMP. The inclusion of Arginine in the P-SARM Synthase AI complex allows for a steady, continuous supply of L-arginine for conversion to NO, allowing for a more effective product. Numerous research studies document the positive effects of L-Arginine and NO on increasing lean body mass, and possibly even mediating greater growth hormone response!!
As you can see, the P-SARM Synthase AI decoction offers an extremely potent blend of testosterone-optimizing, estrogen eliminating, and NO-enhancing effects. The “other” synergistic component blend of RPM, Methyl-AMP Complex, makes this A-CESE unmatched as a mind/muscle connector/contractor through unique peripheral vasostimulatory perfusion and increased cognitive psycho-motor control!!
Methyl-Xanthine Anhydrous Caffeine (MXAC), the first component of the Methyl-AMP Complex, is a metabolic stimulant that heightens mental alertness and focus and improves muscle contraction and coordination. MXAC exerts very strong effects on vasodilation- a process that begins with the activation of Norepinephrine (NE) by MXAC, and the deactivation of cAMP-PDE, an enzyme that breaks down cAMP When MXAC acts on a cell, cAMP-PDE can no longer turn cAMP into AMP, so the action of cAMP is prolonged within the cell. Sound like boring biochemistry? Let’s take a look at the overall effect on the body- when cAMP levels are increased due to cAMP-PDE inactivation, the blood vessels in skeletal muscle tend to relax- the result? More rapid blood flow into the muscle, resulting in bulging vascularity and massive pumps!! MXAC also contains significant amounts of theobromine, a vasodilator that ups the amount of nutrients and oxygen into the brain and skeletal muscle. This greater blood flow to the brain contributes to the cognitive enhancement capabilities of MXAC, by blocking adenosine uptake without activating adenosine receptors- resulting in an increase in dopamine and serotonin levels, causing a positive influence on mood, allowing the user to maintain an optimal training environment.
Another added benefit of MXAC is the ability to stimulate the central nervous system, which may help the athlete feel better and more alert, allowing for focus and clear-headedness. It also stimulates the neural system to fire muscles into action more effectively via norepinephrine stimulation, and also by producing changes in calcium activity, thus stimulating ion transport of potassium into non-contracting tissues. This is important because ion transport helps reduce the increase in blood potassium concentrations during exercise, helping maintain the excitability of the muscle fiber, allowing for a stronger, longer muscle contraction!!
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Chocamine, the other component of the Methyl-AMP Complex, is a specially standardized cocoa extract comprised of several different important constituents that enhance mood, cognitive awareness, and muscle contraction. PEA, tyramine, and L-Tyrosine are the most prevalent constituents of chocamine, and have the biggest impact on the positive effects of the compound. The amino acid tyrosine has profound psycho-stimulant effects for maximal cognitive enhancement- Tyrosine is a precursor to the neurotransmitter dopamine, and in human subjects tyrosine (and Chocamine) supplementation causes increased dopamine and norepinephrine levels, which can be helpful for increasing athletic ability and cognitive function. Tyrosine has the ability to ward off exercise-related fatigue by creating a favorable dopamine to serotonin ratio, which can alter the psychological profile of fatigue for the user. A simple shift in amino acid ratio can create a large difference in perception and concentration, and higher dopamine levels are highly correlated with increased focus and mental connection, along with some mood enhancement/anti-depressant activities. Tyrosine has been shown to reduce or prevent stress-related cognitive impairment, along with preventing the oversecretion of glucocorticoids.
Phenylethylalanine (PEA) and tyramine are two more important constituents of Chocamine. PEA is a biogenic amine derived from the amino acid phenylalanine, and it has some effects very similar to amphetamine. It has strong mood-enhancing qualities, along with the ability to increase focus and offset lack of sleep. Tyramine is another biogenic amine found in Chocamine- it is responsible for the increased release of NE in the neurons, creating an excitatory effect on the CNS. It has also been shown to increase dopamine levels and increase the generation of cAMP, and also to aid in lipolysis (another added bonus of this product). Chocamine also contains significant amounts of caffeine and theobromine, both of which also add a psycho-motor stimulatory effect, thus resulting in increased peripheral vasodilation, muscle contractility, and the mind/muscle stimulatory link!!!
Ready to rev up your workout? RPM takes the guesswork out of your supplementation. Finally there is 1 product that will make selecting your supplements easy. RPM does it all and does it effectively. You feel it from the very first dose. RPM is backed by proven scientific research that will have you reaching your goals in no time. With RPM….. everyday is race day!
Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jun 2;84(11):954-7. Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model
Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Asian J Androl. 2003 Mar;5(1):15-8. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jan 17;84(2):142-5. [Article in Chinese] Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat
Hull EM, Muschamp JW, Sato S. Dopamine and serotonin: influences on male sexual behavior. Physiol Behav. 2004 Nov 15;83(2):291-307
Pavone C, Curto F, Anello G, Serretta V, Almasio PL, Pavone-Macaluso M. J Urol. 2004 Dec;172(6 Pt 1):2347-9. Prospective, crossover comparison of sublingual apomorphine (3mg) with oral sildenafil (50mg) for male erectile dysfunction.
Kruger TH, Haake P, Hartmann U, Schedlowski M, Exton MS. Orgasm-induced prolactin secretion: feedback control of sexual drive? Neurosci Biobehav Rev. 2002 Jan;26(1):31-44.
Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H. BJU Int. 1999 Feb;83(3):269-73. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study.
Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol Int. 1999;63(4):220-3. PMID: 10743698
Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 2003 May-Jun;29(3):207-13. PMID: 12851125
Kim NN, Christianson DW, Traish AM. Role of arginase in the male and female sexual arousal response. J Nutr. 2004 Oct;134(10 Suppl):2873S-2879S; discussion 2895S. Review. PMID: 15465804
Ying, Pan, Wei-Yun Zhang, Xing Xia, and Ling-Dong Kong, “Effects of Icariin on Hypothalamic-Pituitary-Adrenal Axis Action and Cytokine Levels in Stressed Sprague-Dawley Rats” Biol. Pharm. Bull., Vol. 29, 2399-2403.
Aghdasi B, Reid MB, and Hamilton SL. (1997) Nitric oxide protects the skeletal muscle Ca2+ release channel from oxidation induced activation. J Biol Chem 272:25462-25467
Balon TW, Nadler JL. (1997)Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol. 1997 Jan;82(1):359-63.
Etgen GJ Jr, Fryburg DA, Gibbs EM. (1997) Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes Nov;46(11):1915-9.
McAllister RM, Hirai T, Musch TI. (1995) Contribution of endothelium-derived nitric oxide (EDNO) to the skeletal muscle blood flow response to exercise. Med Sci Sports Exerc. Aug;27(8):1145-51
Wilson, JR and Kapoor S. (1993) Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans. J. Appl. Physiol. 75:2740-2744.
12. Young ME, Leighton B.(1998) Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle. Biochem J. Jan 1;329 ( Pt 1):73-9
Liu, HJ et al. [The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells] Zhong Yao Cai. 2006 Oct;29(10):1062-5. Chinese.
PMID: 17326409 [PubMed - in process]
Ning, H et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4.
PMID: 17169663 [PubMed - indexed for MEDLINE]
Jiang, Z. et al Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats. Biol Pharm Bull. 2006 Dec;29(12):2399-403.
PMID: 17142971 [PubMed - indexed for MEDLINE]
Zhang, Z. et al The testosterone mimetic properties of icariin. Asian J Androl. 2006 Sep;8(5):601-5. Epub 2006 Jun 5.
PMID: 16751992 [PubMed - indexed for MEDLINE]
Liu, W. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl. 2005 Dec;7(4):381-8.
PMID: 16281085 [PubMed - indexed for MEDLINE]
Xin, ZC Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8.
PMID: 12646997 [PubMed - indexed for MEDLINE]
Stanislavov, R. and Nikolova. 2003. Treatment of Erectile Dysfunction with Pycnogenol and L-arginine. Journal of Sex and Marital Therapy, 29(3): 207 – 213.
Alba-Roth J, Müller O, Schopohl J, von Werder K (1988). "Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion". J Clin Endocrinol Metab 67 (6): 1186-9.
Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. JPEN. 1986; 10:227-238.
Adams MR, McCredie R, Jessup W, et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 1997; 129:261-269.
Andres A, Morales JM, Praga M, et al. L-arginine reverses the antinatriuretic effect of cyclosporin in renal transplant patients. Nephrol Dial Transplant. 1997; 12:1437-1440.
Bode-Boger SM, Boger RH, Galland A, et al. L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol. 1998; 46:489-497.
Isidori A, Lo Monaco A, Cappa M. A study of growth hormone release in man after oral administration of amino acids. Current Med Res Opinion. 1981; 7:475-481.
Wascher TC, Posch K, Wallner S, et al. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem Biophys Res Commun. 1997; 234:35-38.
Kijuma, I. et al Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.
Sano, T. et al Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed. Thromb Res. 2005;115(1-2):115-21.
Eng, ET et al Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.
Fitzpatrick, DF et al Vasodilating procyanidins derived from grape seeds. Ann N Y Acad Sci. 2002 May;957:78-89.
Yu, H et al [Study of anti-atherosclerosic effect of grape seed extract and its mechanism] Wei Sheng Yan Jiu. 2002 Aug;31(4):263-5. Chinese.
Dell’Agli, H et al n vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.J Agric Food Chem. 2005 Mar 23;53(6):1960-5.
Sen, SK et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci. 2002 May;957:239-49. Review.
LeBail, JC et al Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.Life Sci. 2001 Jan 5;68(7):751-61.
LeBail, JC et al Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells.
Life Sci. 2000 Feb 25;66(14):1281-91.
LeBail, JC et al Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids. .Cancer Lett. 1998 Nov 13;133(1):101-6.
LeLain, L et al Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.
Arayne, LS. Et al Grape fruit juice-drug interactions.Pak J Pharm Sci. 2005 Oct;18(4):45-57. Review.
Ho, PC et al. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds.
J Pharm Pharm Sci. 2001 Sep-Dec;4(3):217-27.
Fuhr, U Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.
Br J Clin Pharmacol. 1993 Apr;35(4):431-6.
Jetter, A. et al Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther. 2002 Jan;71(1):21-9.
Nehlig, A; Daval JL, Debry G (1992 May-Aug). "Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic, and psychostimulant effects". Brain Res Brain Res Rev 17 (2):
Bolton, Ph.D., Sanford; Gary Null, M.S. (1981). Caffeine: Psychology, Use, and Abuse. Orthomolecular Psychiatry 10 (3): 202-211.
Newton, R; Broughton LJ, Lind MJ, Morrison PJ, Rogers HJ, Bradbrook ID (1981). "Plasma and salivary pharmacokinetics of caffeine in man". European Journal of Clinical Pharmacology 21 (1): 45-52.
Ortweiler, W; Simon HU, Splinter FK, Peiker G, Siegert C, Traeger A. (1985). "Determination of caffeine and metamizole elimination in pregnancy and after delivery as an in vivo method for characterization of various cytochrome p-450 dependent biotransformation reactions". Biomed Biochim Acta. 44 (7-8): 1189-99
Graham T, Rush J, van Soeren M (1994). "Caffeine and exercise: metabolism and performance.". Can J Appl Physiol 19 (2): 111-38.
Fredholm B, Bättig K, Holmén J, Nehlig A, Zvartau E (1999). "Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.". Pharmacol Rev 51 (1): 83-133
Verkhratsky A. (2005). "Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons". Physiol. Rev. 85 (1): 201-279.
Dews, P.B. (1984). Caffeine: Perspectives from Recent Research. Berlin: Springer-Valerag.
Ivy, JL; Costill DL, Fink WJ, Lower RW (1979 Spring). "Influence of caffeine and carbohydrate feedings on endurance performance". Med Sci Sports 11 (1): 6-11.
Graham, TE; Spriet, LL (1991 Dec). "Performance and metabolic responses to a high caffeine dose during prolonged exercise". J Appl Physiol 71 (6): 2292-8.
Trice, I; Haymes, EM (Mar 1995). "Effects of caffeine ingestion on exercise-induced changes during high-intensity, intermittent exercise". Int J Sport Nutr 5 (1): 37-44
Lieberman, HR, Corkin S, Spring BJ, Wurtman RJ, and Growden JH. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 42: 366-370, 1985.
Banderet, LE, and Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762, 1989.
Gelenberg AJ, Gibson CJ, Wojcik JD. Neurotransmitter precursors for the treatment of depression. Psychopharmacol Bull 1982;18:7-18.
Wurtman, RJ, and Lewis MC. Exercise, plasma composition and neurotransmission. In: Advances in Nutrition and Top Sport, edited by Brouns F.. Basel: Karger, 1991, vol. 32, p. 94-109.
Romanowski, W, and Grabiec S. The role of serotonin in the mechanism of central fatigue. Acta Physiol Pol 25: 127-134, 1974.
David L. Nelson, Michael M. Cox (2005). Lehninger Principles of Biochemistry. W.H. Freeman and Company, 435–439.
Sir Ghillean Prance, Mark Nesbitt (2004). The Cultural History of Plants. New York: Routledge.
William Gervase Clarence-Smith (2000). Cocoa and Chocolate, 1765-1914. London: Routledge, 10, 31.
Usmani O; Belvisi M, Patel H, Crispino N, Birrell M, Korbonits M, Korbonits D, Barnes P (2005). "Theobromine inhibits sensory nerve activation and cough.". FASEB J 19 (2): 231-3.
Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S. & Crozier, A. 2003. Plasma antioxidants from chocolate. Nature 424, 1013.
Kondo K, Hirano R, Matsumoto A, Igarashi O, Itakura H., Inhibition of LDL oxidation by cocoa, Lancet, November 1996; 348(2):1514.
MATISSEK R., Evaluation of xanthine derivatives in chocolate: nutritional and chemical aspects.
Smit HJ, Gaffan EA, Rogers PJ. (2004) Methylxanthines are the psycho-pharmacologically active constituents of chocolate. Psychopharmacology Nov;176(3-4):412-9.
Bitter Chocolate: Investigating the Dark Side of the World's Most Seductive Sweet, by Carol Off, Random House, 2006.
Chocolate, by the editors of Fine Cooking magazine, 2006.
The True History of Chocolate, by Sophie D. Coe & Michael D. Coe, Thames & Hudson, 1996.
Naked Chocolate, by David Wolfe and Shazzie, Rawcreation, 2005.
The Great Book of Chocolate, by David Lebovitz, Ten Speed Press, 2004.
The Chocolate Connoisseur, by Chloe Doutre-Roussel, Piatkus, 2005.
Green & Black's Chocolate Recipes, by Kyle Cathie Limited, 2003.
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04-20-2007, 04:48 PM
AWE YEAH BABY!! Thats right i will say it again A supplement in a league of its own most innovative product to DATE!!!!! WE need to think of a whole new category for this one!!! HMMMMM........
You know i will let you guys decide!!
04-20-2007, 04:49 PM
04-20-2007, 04:51 PM
Too much nerd stuff to read all at once. I limit my nerdom to computer books!. Other things I like explained to me in plain and simple terms.
04-20-2007, 04:55 PM
04-20-2007, 04:57 PM
04-20-2007, 04:59 PM
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04-20-2007, 06:42 PM
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04-20-2007, 07:09 PM
One question though, anyone popping accidental hard on's on this stuff? I already get that, lol And if this stuff is as potent as you say my gf is going to be very very sore, lol
04-20-2007, 07:13 PM
04-20-2007, 07:13 PM
04-20-2007, 07:25 PM
04-20-2007, 07:30 PM
04-20-2007, 07:36 PM
I signed up for a sample, and got an email back, so I presume a sample is on its way...So, let's say I like this sample. How do I get more? Is the product available yet?
04-20-2007, 07:44 PM
We are waiting for everything to come in Labels and ect. Rms correct me if i am wrong but prob about 3-4 weeks till we release it!!
The sample should give you enough for 2-3 workouts!! Then you have to go through RPM withdraw till we get them out!!
04-20-2007, 07:55 PM
04-20-2007, 07:56 PM
04-20-2007, 08:50 PM
Naringin is also a PDE inhibitor w/ vasodillatory properties as well
Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin.
* Orallo F,
* Camina M,
* Alvarez E,
* Basaran H,
* Lugnier C.
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela (La Coruna), Spain. [email protected]
The potential vasorelaxant, antioxidant and cyclic nucleotide phosphodiesterase (PDE) inhibitory effects of the citrus-fruit flavonoids naringin and (+/-)-naringenin were comparatively studied for the first time in this work. (+/-)-Naringenin (1 microM - 0.3 mM) did not affect the contractile response induced by okadaic acid (OA, 1 microM). However, (+/-)-naringenin relaxed, in a concentration-dependent manner, the contractions elicited by phenylephrine (PHE, 1 microM) or by a high extracellular KCl concentration (60 mM) in intact rat aortic rings. Mechanical removal of endothelium and/or pretreatment of aorta rings with glibenclamide (GB, 10 microM) or tetraethylammonium (TEA, 2 mM) did not significantly modify the vasorelaxant effects of this flavanone. (+/-)-Naringenin (10 microM - 0.1 mM) did not alter the basal uptake of 4) Ca2+ but decreased the influx of 45Ca2+ induced by PHE and KCl in endothelium-containing and endothelium-denuded rat aorta. (+/-)-Naringenin (10 microM - 0.1 mM) was ineffective to scavenge superoxide radicals (O*2-) generated by the hypoxanthine (HX)-xanthine oxidase (XO) system and/or to inhibit XO activity. (+/-)-Naringenin (0.1 mM) significantly increased the production of cGMP and cAMP decreased by PHE (1 microM) and high KCl (60 mM) in cultured rat aortic myocytes. (+/-)-Naringenin preferentially inhibited calmodulin (CaM)-activated PDE1, PDE4 and PDE5 isolated from bovine aorta with IC50 values of about 45 microM, 60 microM and 68 microM, respectively. In contrast, the 7-rhamnoglucoside of (+/-)-naringenin, naringin (1 microM - 0.3 mM), was totally inactive in all experiments. These results indicate that the vasorelaxant effects of (+/-)-naringenin seem to be basically related to the inhibition of PDE1, PDE4 and PDE5 activities.
04-20-2007, 09:15 PM
Okay, enough waiting! What have he attempted again? Enough questioning, and let's get this on!
As most of you know, I am logging X2 and had the opportunity to test this product. All I can say is: Surprising, subtile, and very good stuff. Okay, the dosage is 4 caps. I noticed that like some mentionned in this thread, that the magic stick is just getting crazy. Some might not want to hear this, but I had to beat the meat 3 times in one evening!! Enough of that subject. On with my crazy plans. I took 8 caps pre wo. Yes, 8 caps. I am in a recomp phase and training every set to failure. On top of that, they're all drop sets! AAAAAAAAARRRRRRRRRRRRGGGGGGGGG GGGHHHHHHHHHHHHHH! I WAS ON FIRE! GET OUT OF MY WAY YOU WEAKS! RPM at 8 caps made me pumped until the last rep. when putting my t-shirt, it felt so tight, it was incredible. I still am on a very high cal. diet, and let me tell you, I can't wait to train again monday!
04-20-2007, 09:22 PM
Bro you have got some BALLS!!!! 8!!!!?
The highest I have gone is 5 before a workout, and I seriously thought I was going to kill someone- it just gives you this super-intense DRIVE to not just complete the workout, but to kill the iron in the process- makes me aggressive as hell, and crazy focused.....
Don runs about 3 bills, and he is even afraid to take any more than 5- Johnny S. won't take more than 4- he says it makes him too aggressive!!!
04-20-2007, 09:25 PM
04-20-2007, 09:30 PM
I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
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