For Your Viewing Pleasure, The Detailed RPM Write-up
- 04-20-2007, 03:39 PM
For Your Viewing Pleasure, The Detailed RPM Write-up
Goal. We all have them. But what truly is a goal. Webster dictionary defines goal as:
1. The end toward which effort is directed
2. The terminal point of a race.
When we think of our goals we think of how quickly can we accomplish them. Whether your goal is losing a few pounds, increasing performance, or bursting through a new plateau, we all want to race to the finish line. Unfortunately, we all have lives and sometimes life gets in the way and knocks us out of the race. We seek out products that make claims that will help us reach our goals and reach them quickly. However, we find only once again we have lost our hard earned dollars and have become no closer to the finish line. Well, not anymore!
Applied Nutriceuticals has the answer to putting you back in the drivers seat and racing towards your goal at speeds you never thought possible! Finally there is a product that makes every day…..Race Day! That product is from Applied Nutriceuticals. What is RPM? Rpm is an exclusive formula that provides explosive energy, crisp uncanny mental focus, noticeable strength increases, all while giving you insane pumps, suppressed estrogen, increased testosterone, while incinerating fat!!!! RPM is instant gratification from the very first dose! RPM is in its own race class!
Lets look under the hood at this super-charged formula………………
RPM’s formula is so unique it requires it’s own class. RPM, the supplement world’s first Anabolic-Cognitive Energy System Enhancer (A-CESE), where anabolics meet cognitive psy-stimulants!
How do A-CESEs differ from other product categories on the market? An A-CESE is a product that contains testosterone-like, anti-catabolic, and aromatase-inhibiting properties, while at the same time delivering optimal mind/muscle connection/contraction through unique peripheral vasostimulatory perfusion and increased cognitive psycho-motor control. RPM combines P-SARM Synthase AI- a unique blend of research-grade icariin, Arginine , Naringenin, and oligomeric proanthocyanidins (OPC’s), and Methyl-AMP Complex, a powerful blend of methyl-xanthine caffeine and chocamine.
AN uses the highest quality ingredients in scientifically-proven doses to achieve maximal results!! In the product constituent P-SARM Synthase AI, RPM utilizes pharmaceutical-grade Icariin, a potent vasodilator with anabolic and anti-catabolic effects, that can also yield stronger, more forceful muscle contractions!! Icariin works through several different mechanisms: by increasing nitric oxide (NO) through PDE5 inhibition, by acting as a potent anti-catabolic agent that increases the testosterone to cortisol ratio, by increasing muscle contractility by deactivating AchE (Acetycholinesterase), and by boosting endogenous testosterone levels through increasing cAMP and luteinizing hormone and decreasing prolactin. It also is considered a Phytochemical Selective Androgen Receptor Modulator or P-SARM. A P-SARM is a phytochemical (plant-derived) compound that mimics the effects of androgens on , strength, bone growth, drive, and sexual function, while at the same time not negatively effecting blood lipids or blood pressure. P-SARMs provide an excellent alternative to other “enhancement” products on the market, including oral bioavailability, biochemical structure, and lack of steroid-related side-effects!!!
As mentioned before, Icariin has potent anti-catabolic effects, along with testosterone-mimicking and muscle-contraction-enhancing benefits - several studies have shown that it actually competes with glucocorticoids for receptor sites in a manner similar to testosterone, while at the same time improving the testosterone to cortisol ratio. This is caused by two different mechanisms of action: the aforementioned competition with glucocorticoids, and also increased testosterone production, through increased cAMP (cyclic AMP, a second messenger important in hormone signaling) levels, luteininzing hormone (LH) levels, the actual mimicry of testosterone in spermatogenesis, and decreased prolactin levels. Icariin seems to block glucorticoids from binding to cortisol receptors, thus blocking the action of cortisol. This alone will cause an anabolic effect by positively skewing the T:C ratio, which is a trigger for greater protein synthesis, increased aggression towards the iron, and insane muscle contractions!!
RPM also reduces aromatase and estradiol, allowing for the greater production of T as a substrate for aromatase activity- as users of RPM report huge rises in strength, physique hardness, and positive aggression while using this compound, an effect that can be at least partially attributed to the androgen-mimicking qualities of Icariin. RPM also has a dopaminergic effect, allowing for increased dopamine levels and decreased prolactin levels, both of which are triggers for increased testosterone. Also, icariin can enhance muscle contraction by decreasing the effects of acetylcholinesterase (AChE). Acetylcholine (Ach) is a neurotransmitter necessary for muscle contraction, and AChE is responsible for disabling ACh at the neuromuscular junction. Icarin actually blocks this disabling action, allowing for ACh to stay at the synapse, and better exert its effects, for a longer period of time- allowing for harder and stronger muscle contractions!!!
Icariin is a selective inhibitor of cyclic guanosine monophosphate (cGMP)- specific phosphodiasterase type 5 (PDE5 for the purposes of this article). This is important, because PDE5 hydrolyze cGMP into an inactive molecule. cGMP is important because nitric oxide (NO) requires cGMP to moderate vascular control and vasodilation. So, essentially, no cGMP, no vasodilation (the “PUMP”), because NO requires cGMP to work. The more cGMP, the more NO-induced vasodilation- therefore greater pumps!! Icariin stops PDE5 from disabling cGMP and allowing cGMP to extend its activity, which exerting the effects of NO in skeletal muscle, allowing for a stronger muscle contraction and pump. Viagra is probably the most well known PDE5 inhibitor on the market- but how does Icariin compare? In scientific studies, pure icariin has been found to have roughly one-tenth the PDE5 inhibitory activity and nitric oxide productivity of Viagra- and in P-SARM Synthase AI, the dosage is tailored appropriately to reflect these findings!! In short, the PDE5 inhibition displayed by icariin puts RPM in a class above all other NO enhancers- the effects can actually be viewed as “pharmaceutical-like!!!!”
The inclusion of oligomeric proanthocyanidins (OPCs) are also essential in the creation of any good A-CESE, because OPCs contain their own combination of unique and effective constituents, which allows P-SARM Synthase AI to exert potent anti-aromatase (AI), anti-oxidant, and vasodilatory effects. OPCs have been shown in numerous studies to have the ability to block the conversion of androgens to estrogens, with a potency comparable to several widely marketed pharmaceutical AI inhibitors (Arimidex). RPM reduces aromatase activity and estradiol as well, allowing for more testosterone (T) to be produced!!
Compounds exhibiting AI characteristics also reduce SHBG (steroid hormone binding globulin) as well. This is important, because this allows for a drastic increase in free testosterone (T). When this occurs, coupled with T levels that are already high from decreased aromatization of estrogen, WATCH OUT!!!! Look for longer, harder more workouts, rapid strength increases with personal records on all your lifts, greater protein synthesis, quicker recovery, while also allowing for increased lipolysis (fat burning)!! This, coupled with the androgen-mimicking qualities of the P-SARM Icariin, gives the product a unique “hardness” enhancing quality, giving the user of the product an “eye” popping type of physique that looks to be cut from stone!!!
OPCs also protect against free radicals and subsequent DNA and oxidative damage, qualities that are extremely important to the hard-training athlete. Oxidative damage is a common occurrence during stress and hard training, and it can stop lean body mass gains in their tracks!! Less oxidative damage, better recovery, giving you the ability to train longer and harder!!! The nitric oxide-enhancing, vasodilatory properties of OPCs have also been documented in countless studies. The flavonoids contained in OPCs actually increase levels of Nitric Oxide Synthase (NOS), the enzyme that allows for the conversion of arginine to nitric oxide. This is very important, as nitric oxide synthase competes with arginase for the utilization of the amino acid . Arginase converts L-arginine into ornthine, and increased arginase and ornthine activity, are counteractive to the nitric oxide production pathway. By increasing NOS, the flavonoids in OPCs “crowd out” arginase, allowing for more arginine to be processed into NO. The result is higher NO levels, even greater vasodilation, and gigantic pumps and a physique hard as nails!!
Naringin, and its novel component Naringenin, also exert extensive effects within the P-SARM Synthase AI complex. Naringin (and Naringenin) exhibit remarkable aromatase and estrogen-inhibiting properties by decreasing the cytochrome P450arom isoform, an enzyme that also allows for the oxidative metabolism for chemical modification and degradation of oral medications. This can have very positive effects on the T:E ratio, and the combination of OPCs and Naringenin can be potentially additive or synergistic in eliminating estrogen, and allowing for more circulating free testosterone and all of its benefits!!! Naringin and Naringenin have also been shown to have profound effects on the metabolism of caffeine and PDE5 inhibitors such as Icariin, allowing for these compounds to be much more effective on a per dose basis- by up to 35%!!!
L-Arginine is also an essential component of the P-SARM Synthase AI . L-Arginine is an amino acid that is necessary for cell division, the healing of wounds, displacing ammonia from the body, the release of hormones, and immune function. Most importantly, L-arginine is necessary for the production of Nitric Oxide (NO, as mentioned above), a messenger gas responsible for the promotion of blood vessel relaxation (“pump”), and the regulation of vascular tone. NO is derived from arginine and oxygen via Nitric Oxide synthase (NOS), and, as mentioned above, NO exerts its effects on tissue through cGMP. The inclusion of Arginine in the P-SARM Synthase AI complex allows for a steady, continuous supply of L-arginine for conversion to NO, allowing for a more effective product. Numerous research studies document the positive effects of L-Arginine and NO on increasing lean body mass, and possibly even mediating greater growth hormone response!!
As you can see, the P-SARM Synthase AI decoction offers an extremely potent blend of testosterone-optimizing, estrogen eliminating, and NO-enhancing effects. The “other” synergistic component blend of RPM, Methyl-AMP Complex, makes this A-CESE unmatched as a mind/muscle connector/contractor through unique peripheral vasostimulatory perfusion and increased cognitive psycho-motor control!!
Methyl-Xanthine Anhydrous Caffeine (MXAC), the first component of the Methyl-AMP Complex, is a metabolic stimulant that heightens mental alertness and focus and improves muscle contraction and coordination. MXAC exerts very strong effects on vasodilation- a process that begins with the activation of Norepinephrine (NE) by MXAC, and the deactivation of cAMP-PDE, an enzyme that breaks down cAMP When MXAC acts on a cell, cAMP-PDE can no longer turn cAMP into AMP, so the action of cAMP is prolonged within the cell. Sound like boring biochemistry? Let’s take a look at the overall effect on the body- when cAMP levels are increased due to cAMP-PDE inactivation, the blood vessels in skeletal muscle tend to relax- the result? More rapid blood flow into the muscle, resulting in bulging vascularity and massive pumps!! MXAC also contains significant amounts of theobromine, a vasodilator that ups the amount of nutrients and oxygen into the brain and skeletal muscle. This greater blood flow to the brain contributes to the cognitive enhancement capabilities of MXAC, by blocking adenosine uptake without activating adenosine receptors- resulting in an increase in dopamine and serotonin levels, causing a positive influence on mood, allowing the user to maintain an optimal training environment.
Another added benefit of MXAC is the ability to stimulate the central nervous system, which may help the athlete feel better and more alert, allowing for focus and clear-headedness. It also stimulates the neural system to fire muscles into action more effectively via norepinephrine stimulation, and also by producing changes in calcium activity, thus stimulating ion transport of potassium into non-contracting tissues. This is important because ion transport helps reduce the increase in blood potassium concentrations during exercise, helping maintain the excitability of the muscle fiber, allowing for a stronger, longer muscle contraction!!
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Chocamine, the other component of the Methyl-AMP Complex, is a specially standardized cocoa extract comprised of several different important constituents that enhance mood, cognitive awareness, and muscle contraction. PEA, tyramine, and L-Tyrosine are the most prevalent constituents of chocamine, and have the biggest impact on the positive effects of the compound. The amino acid tyrosine has profound psycho-stimulant effects for maximal cognitive enhancement- Tyrosine is a precursor to the neurotransmitter dopamine, and in human subjects tyrosine (and Chocamine) supplementation causes increased dopamine and norepinephrine levels, which can be helpful for increasing athletic ability and cognitive function. Tyrosine has the ability to ward off exercise-related fatigue by creating a favorable dopamine to serotonin ratio, which can alter the psychological profile of fatigue for the user. A simple shift in amino acid ratio can create a large difference in perception and concentration, and higher dopamine levels are highly correlated with increased focus and mental connection, along with some mood enhancement/anti-depressant activities. Tyrosine has been shown to reduce or prevent stress-related cognitive impairment, along with preventing the oversecretion of glucocorticoids.
Phenylethylalanine (PEA) and tyramine are two more important constituents of Chocamine. PEA is a biogenic amine derived from the amino acid phenylalanine, and it has some effects very similar to amphetamine. It has strong mood-enhancing qualities, along with the ability to increase focus and offset lack of sleep. Tyramine is another biogenic amine found in Chocamine- it is responsible for the increased release of NE in the neurons, creating an excitatory effect on the CNS. It has also been shown to increase dopamine levels and increase the generation of cAMP, and also to aid in lipolysis (another added bonus of this product). Chocamine also contains significant amounts of caffeine and theobromine, both of which also add a psycho-motor stimulatory effect, thus resulting in increased peripheral vasodilation, muscle contractility, and the mind/muscle stimulatory link!!!
Ready to rev up your workout? RPM takes the guesswork out of your supplementation. Finally there is 1 product that will make selecting your supplements easy. RPM does it all and does it effectively. You feel it from the very first dose. RPM is backed by proven scientific research that will have you reaching your goals in no time. With RPM….. everyday is race day!
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04-20-2007, 03:48 PM
AWE YEAH BABY!! Thats right i will say it again A supplement in a league of its own most innovative product to DATE!!!!! WE need to think of a whole new category for this one!!! HMMMMM........
You know i will let you guys decide!!
04-20-2007, 03:49 PM
04-20-2007, 03:51 PM
Too much nerd stuff to read all at once. I limit my nerdom to computer books!. Other things I like explained to me in plain and simple terms.
04-20-2007, 03:55 PM
04-20-2007, 03:57 PM
04-20-2007, 03:59 PM
04-20-2007, 04:20 PM
04-20-2007, 04:21 PM
04-20-2007, 04:22 PM
04-20-2007, 05:21 PM
hmm... the suspense builds.........
Applied Nutriceuticals Representative
Better Results Through Science
Success occurs when everything you have is APPLIED.
Have you heard about N.O. Uptake? ;-)
04-20-2007, 05:26 PM
04-20-2007, 05:42 PM
04-20-2007, 06:05 PM
04-20-2007, 06:09 PM
One question though, anyone popping accidental hard on's on this stuff? I already get that, lol And if this stuff is as potent as you say my gf is going to be very very sore, lol
04-20-2007, 06:13 PM
04-20-2007, 06:13 PM
04-20-2007, 06:25 PM
04-20-2007, 06:30 PM
04-20-2007, 06:36 PM
I signed up for a sample, and got an email back, so I presume a sample is on its way...So, let's say I like this sample. How do I get more? Is the product available yet?
04-20-2007, 06:44 PM
We are waiting for everything to come in Labels and ect. Rms correct me if i am wrong but prob about 3-4 weeks till we release it!!
The sample should give you enough for 2-3 workouts!! Then you have to go through RPM withdraw till we get them out!!
04-20-2007, 06:55 PM
04-20-2007, 06:56 PM
04-20-2007, 07:50 PM
Naringin is also a PDE inhibitor w/ vasodillatory properties as well
Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin.
* Orallo F,
* Camina M,
* Alvarez E,
* Basaran H,
* Lugnier C.
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela (La Coruna), Spain. email@example.com
The potential vasorelaxant, antioxidant and cyclic nucleotide phosphodiesterase (PDE) inhibitory effects of the citrus-fruit flavonoids naringin and (+/-)-naringenin were comparatively studied for the first time in this work. (+/-)-Naringenin (1 microM - 0.3 mM) did not affect the contractile response induced by okadaic acid (OA, 1 microM). However, (+/-)-naringenin relaxed, in a concentration-dependent manner, the contractions elicited by phenylephrine (PHE, 1 microM) or by a high extracellular KCl concentration (60 mM) in intact rat aortic rings. Mechanical removal of endothelium and/or pretreatment of aorta rings with glibenclamide (GB, 10 microM) or tetraethylammonium (TEA, 2 mM) did not significantly modify the vasorelaxant effects of this flavanone. (+/-)-Naringenin (10 microM - 0.1 mM) did not alter the basal uptake of 4) Ca2+ but decreased the influx of 45Ca2+ induced by PHE and KCl in endothelium-containing and endothelium-denuded rat aorta. (+/-)-Naringenin (10 microM - 0.1 mM) was ineffective to scavenge superoxide radicals (O*2-) generated by the hypoxanthine (HX)-xanthine oxidase (XO) system and/or to inhibit XO activity. (+/-)-Naringenin (0.1 mM) significantly increased the production of cGMP and cAMP decreased by PHE (1 microM) and high KCl (60 mM) in cultured rat aortic myocytes. (+/-)-Naringenin preferentially inhibited calmodulin (CaM)-activated PDE1, PDE4 and PDE5 isolated from bovine aorta with IC50 values of about 45 microM, 60 microM and 68 microM, respectively. In contrast, the 7-rhamnoglucoside of (+/-)-naringenin, naringin (1 microM - 0.3 mM), was totally inactive in all experiments. These results indicate that the vasorelaxant effects of (+/-)-naringenin seem to be basically related to the inhibition of PDE1, PDE4 and PDE5 activities.
04-20-2007, 08:15 PM
Okay, enough waiting! What have he attempted again? Enough questioning, and let's get this on!
As most of you know, I am logging X2 and had the opportunity to test this product. All I can say is: Surprising, subtile, and very good stuff. Okay, the dosage is 4 caps. I noticed that like some mentionned in this thread, that the magic stick is just getting crazy. Some might not want to hear this, but I had to beat the meat 3 times in one evening!! Enough of that subject. On with my crazy plans. I took 8 caps pre wo. Yes, 8 caps. I am in a recomp phase and training every set to failure. On top of that, they're all drop sets! AAAAAAAAARRRRRRRRRRRRGGGGGGGGG GGGHHHHHHHHHHHHHH! I WAS ON FIRE! GET OUT OF MY WAY YOU WEAKS! RPM at 8 caps made me pumped until the last rep. when putting my t-shirt, it felt so tight, it was incredible. I still am on a very high cal. diet, and let me tell you, I can't wait to train again monday!
04-20-2007, 08:22 PM
Bro you have got some BALLS!!!! 8!!!!?
The highest I have gone is 5 before a workout, and I seriously thought I was going to kill someone- it just gives you this super-intense DRIVE to not just complete the workout, but to kill the iron in the process- makes me aggressive as hell, and crazy focused.....
Don runs about 3 bills, and he is even afraid to take any more than 5- Johnny S. won't take more than 4- he says it makes him too aggressive!!!
04-20-2007, 08:25 PM
04-20-2007, 08:30 PM
I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
04-20-2007, 08:35 PM
Naringin makes PDE5 inhibitors more bioavaliable and last longer in the system (hint: Icariin is a PDE5 inhibitor)
check out this study w/ slidenafil (Viagra)
Clin Pharmacol Ther. 2002 Jan;71(1):21-9. Links
Clin Pharmacol Ther. 2005 Oct;78(4):441-3.
Effects of grapefruit juice on the pharmacokinetics of sildenafil.
* Jetter A,
* Kinzig-Schippers M,
* Walchner-Bonjean M,
* Hering U,
* Bulitta J,
* Schreiner P,
* Sorgel F,
* Fuhr U.
Institute for Pharmacology, Clinical Pharmacology, University of Koln, Germany. firstname.lastname@example.org
BACKGROUND AND OBJECTIVES: Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N -desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this study we investigated the influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N -desmethylsildenafil. METHODS: In a randomized crossover study, 24 healthy white male volunteers received single 50-mg doses of sildenafil. Two doses each of 250 ml grapefruit juice or water, respectively, were administered 1 hour before and together with the drug. Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). RESULTS: Grapefruit juice changed the area under the sildenafil plasma concentration-time curve from time zero to infinity [AUC(0-infinity) from 620 [1.53] ng/ml x h to 761 [1.58] ng/ml x h (geometric mean with geometric standard deviation), corresponding to a 23% increase (90% confidence interval, 13%-33%). N-Desmethyl sildenafil AUC(0-infinity) increased by 24% (90% confidence interval, 17%-32%). Maximum plasma concentrations (C(max)) of sildenafil and N -desmethylsildenafil were essentially unchanged. There was a trend toward a prolonged time to reach C(max) during the grapefruit juice period (from a median of 0.75 hour to a median of 1.13 hours), corresponding to an increase by 0.25 hour (90% confidence interval, 0-0.63 hour). Interindividual variability was pronounced in both periods. CONCLUSIONS: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.
04-20-2007, 08:36 PM
04-20-2007, 08:37 PM
04-20-2007, 08:55 PM
04-20-2007, 08:58 PM
04-20-2007, 09:19 PM
Awesome NEWS GUYS!!!!
JJ you are a mad man taking 8 prework out you are a CHAMP!!!!
Glad to see the great results!!
This stuff just keeps BUILDING IT NEVER STOPS!!!! I NEED MORE I RAN OUT!!!!
But being a team player i want everyone on the board to get them i can wait!! I am already hooked!!!
Hey Rms can you set some carolina girls aside for me when i come and visit!!!!!
04-20-2007, 09:47 PM
And yeah, jjohn, poppin 8 caps is MANIACAL. Any more than 4 for me and I'd probably go RPM-rage on some random passerby.
Oh random: I got Cable internet hooked up at da crib.... I'm about to multiply my posts. lol
Applied Nutriceuticals Representative
Better Results Through Science
Success occurs when everything you have is APPLIED.
Have you heard about N.O. Uptake? ;-)
04-20-2007, 09:50 PM
LAN We need to get together and POP 8 pills AND ROCK SOME WEIGHTS!! MAKE A VIDEO CAUSE THERE WILL BE BLOOD!!!!!
PROB our own due to BLEED FROM THE EYES WITH INTENSITY!!!! AHHHHHH!!!!
04-20-2007, 09:53 PM
04-21-2007, 02:29 AM
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