looking for proven supps that increase receptorand sensitivity, and by proven I guess I mean it's been tried by the AM community in general and accepted. Only three that come to mind are
JW- increase receptor sensitivity
Xfactor- increase and sensitivity
Viraloid- "opens" additional receptors (not sure if 'proven', going off product literature)
just trying to come up with stacking options for supps that are very anabolic in nature and get some really good synergy going.
opinions appreciated. thanks
X-Factor (AA) release controls much of the local shift in physiology that will facilitate growth. Among other things it sensitizes the local tissues to hormones and growth factors, directing growth to them, and not to areas of the body that don't need it. Much of its anabolic effect is mediated by eicosanoids (PGE2/PGF2alpha), however, other products of AA have been implicated in these functions as well. The actions of AA in regards to local muscle repair are very diverse, and include:
- Increasing the density of androgen receptors/local T sensitivity (PG's)
- Upregulating local insulin sensitivity (PGE2)
- Upregulating local NO production, which aids satellite cell activation via increasing levels of Hepatocyte growth factor (PGE2)
- Upregulating local IGF-1 receptor expression (PGF2a)
- Upregulating expression or sensitivity to other growth factors like TNF, FGF, IL's, (various)
MOTIV8 II Challenge
-=The Big Squirrel Nut Swingers=-
Sounds like LCLT has some promise, I only found one "solid" product that incorporates it: MAN Body Octane, and it's write-up echoes some of the pubmed article conclusions
"The positive results from LCLT administration are believed to be a result of enhanced oxygen supply to the muscle by means of increased blood flow. In addition to that, it appears that LCLT may support protein synthesis and anabolic response to exercise by protecting anabolic receptors from excessive damage as a result of resistant exercise. In simple terms, the use of LCLT not only will enhance performance and prevent fatigue, but more importantly LCLT promotes recovery."
"In conclusion, both the 1- and 2-g doses were effective in mediating various markers of metabolic stress and of muscle soreness. Use of LCLT appears to attenuate metabolic stress and the hypoxic chain of events leading to muscle damage after exercise."
"Under these experimental conditions, chronic LCLT supplementation increased CHO oxidation in males during exercise but this was not observed in females."
BTW, just wanted to chime in wrt X-Factor. I used it at 1,500 mg per day and, yes, it got very pricey at that dose. However, I had very good results. Strength was up and most importantly, I lost a good amount of fat. Diet was maintanence calories and still in a month, I went down like 3 lbs -I am at around 10% bf so 3 lbs is not insignificant for me and would be pretty darn impossible to lose while on maint. calories for a whole month.
"know that NOW sells an LCLT-only product in varying doses"
any info on price (couldn't find it in some of the on-line retailers I looked at)? did anybody ever read of this compound being used for bodybuilding purposes in any forum? any side effects?
The best price that I'm aware of is $34 for a 1000mg/100 tab bottle. I'm pretty sure I can't give out the site though since they're not a board sponsor.