Fish Oil Dosage

[lawnboy246]

Just started using Kirkland Signature, Enteric Coated, Extra Strength Fish Oil.

1 softgel = Natural Fish Oil Concentrate 850mg
Omega 3 EPA 240mg
Omega 3 DHA 200mg

For a 200lb person, what would be the optimal number of softgels on a daily basis?

[sjfou]

i say 6-8g

[NO HYPE]

i say 6-8g

That's a bit excessive.

Keep in mind that DHA levels should always be kept at lower levels than EPA.

While DHA displays neuroprotective properties.... when administered in excess, can actually display neurodegenerative properties.

AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

Formation of Highly Reactive gamma -Ketoaldehydes (Neuroketals) as Products of the Neuroprostane Pathway -- Bernoud-Hubac et al. 276 (33): 30964 -- Journal of Biological Chemistry

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

[lawnboy246]

So based on the amount per serving of 1 softgel, about 6 softgels each day?

That's a bit excessive.

Keep in mind that DHA levels should always be kept at lower levels than EPA.

While DHA displays neuroprotective properties.... when administered in excess, can actually display neurodegenerative properties.

AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

Formation of Highly Reactive gamma -Ketoaldehydes (Neuroketals) as Products of the Neuroprostane Pathway -- Bernoud-Hubac et al. 276 (33): 30964 -- Journal of Biological Chemistry

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

[sjfou]

"Keep in mind that DHA levels should always be kept at lower levels than EPA" **** - i thought it was the other way 'round! maybe ive reading too much at t-nation.

[lawnboy246]

So about 6 softgels each day based on the indicated serving sound about right?

[NO HYPE]

So about 6 softgels each day based on the indicated serving sound about right?

For myself.... I ingest around 1000mg for EPA, and about 650mg DHA per day.