Fish Oil Dosage

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    Smile Fish Oil Dosage


    Just started using Kirkland Signature, Enteric Coated, Extra Strength Fish Oil.

    1 softgel = Natural Fish Oil Concentrate 850mg
    Omega 3 EPA 240mg
    Omega 3 DHA 200mg

    For a 200lb person, what would be the optimal number of softgels on a daily basis?

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    i say 6-8g
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    Quote Originally Posted by sjfou View Post
    i say 6-8g
    That's a bit excessive.

    Keep in mind that DHA levels should always be kept at lower levels than EPA.

    While DHA displays neuroprotective properties.... when administered in excess, can actually display neurodegenerative properties.

    AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.

    Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

    Formation of Highly Reactive gamma -Ketoaldehydes (Neuroketals) as Products of the Neuroprostane Pathway -- Bernoud-Hubac et al. 276 (33): 30964 -- Journal of Biological Chemistry

    Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology
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    So based on the amount per serving of 1 softgel, about 6 softgels each day?


    Quote Originally Posted by NO HYPE View Post
    That's a bit excessive.

    Keep in mind that DHA levels should always be kept at lower levels than EPA.

    While DHA displays neuroprotective properties.... when administered in excess, can actually display neurodegenerative properties.

    AA and DHA are the most vulnerable targets for free radical-catalyzed lipid peroxidation. Docosanoids/neuroprostanes, are oxidation products of DHA. The compounds 4-hydroxy-2-hexenal/neuroketals, remain esterified to phospholipids, significantly inhibit proteasome, and are highly cytotoxic. This oxidative damage can lead to docosanoid-induced neurodegeneration, and is associated with neurodegenerative disease.

    Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology

    Formation of Highly Reactive gamma -Ketoaldehydes (Neuroketals) as Products of the Neuroprostane Pathway -- Bernoud-Hubac et al. 276 (33): 30964 -- Journal of Biological Chemistry

    Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease -- Montine and Morrow 166 (5): 1283 -- American Journal of Pathology
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    "Keep in mind that DHA levels should always be kept at lower levels than EPA" **** - i thought it was the other way 'round! maybe ive reading too much at t-nation.
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    So about 6 softgels each day based on the indicated serving sound about right?
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    Quote Originally Posted by lawnboy246 View Post
    So about 6 softgels each day based on the indicated serving sound about right?
    For myself.... I ingest around 1000mg for EPA, and about 650mg DHA per day.
  

  
 

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