Cissus and X-Factor?

Oswizle

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J Ethnopharmacol. 2006 Sep 26;: [Pubmed] [Scholar] [Select] [Drop] [Hide] [Show]
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
Ampai Panthong, Wanicha Supraditaporn, Duangta Kanjanapothi, Tawat Taesotikul, Vichai Reutrakul
Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.
 
jjohn

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J Ethnopharmacol. 2006 Sep 26;: [Pubmed] [Scholar] [Select] [Drop] [Hide] [Show]
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
Ampai Panthong, Wanicha Supraditaporn, Duangta Kanjanapothi, Tawat Taesotikul, Vichai Reutrakul
Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.
Well, this is pretty interesting, as I am sure Phoaphate Bond was OK with it. I didn't heard of anyone trying it, but that would be something interesting to take a look at...
 
SMOKEPALADIN

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Sorry I am a bit comfused, some of the terminology I am unfamiliar with. Does this mean Cissus lowers the affect of X-Factor? I was going to do this for my next stack right after NewYears.
 
jjohn

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Sorry I am a bit comfused, some of the terminology I am unfamiliar with. Does this mean Cissus lowers the affect of X-Factor? I was going to do this for my next stack right after NewYears.
In this study, Cissus lowers the effects of AA. Fat people, unhealthy people have higher AA levels and it can become dangerous and unhealthy. This is why you do cycles. People that don't know XF will see AA as bad IMO..
 
Aeternitatis

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That's some interesting info and I really don't know what to say about it. Although I have a feeling that this doesn't mean it interferes with XF's ability to induce accelerated muscle/strength growth.

But we'll see what PB has to say about it.
 
jjohn

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I am curious as well. Very strange.. New tests coming up?? LOL
 
DeerDeer

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Personally, I would stay away from all Arachadonic Acid products. Have you guys checked out the prostaglandin/leukotriene mediated proinflammatory (among other processes) involved in the pathway? What's to say it will not activate and disregulate this pathway? Rather than scanning one out of my medical textbooks, I found this image on the web...



So think about it, nsaids are taken to block the conversion to PGs/TX's, glucocorticoids are taken to block the conversion TO AAcid. So what would th epoint be of inducing the proinflammatory state? Is the AAcid modified to show preference to one of the pathways or is it just run of the mill AAcid?

So if you scroll down this page: Anti-Inflammatory Drugs

You can see the pro inflam/antiinflam, vasoconstrict/dilate properties these important mediators take part in. What is to say that this does not become dysregulated? Would you really want to mess around with this global pathway? This is only the tip of the iceberg....it has probably been hashed out before but wanted to rekindle these thoughts.

The use of cissus alone woul dbe beneficial due to its documented antiinflammatory effects, adding an AAcid product would be meaningless given the pathway of its activity, likely negating the effects of CG.

Cheers,
 

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