Creatine Article

  1. New Member
    Speischerkater's Avatar
    Join Date
    Nov 2004
    Age
    35
    Posts
    54
    Rep Power
    150
    Level
    6
    Lv. Percent
    84.62%

    Exclamation Creatine Article


    CREATINE SUPPLEMENTATION AUGMENTS THE INCREASE IN SATELLITE CELL AND MYONUCLEI NUMBER IN HUMAN SKELETAL MUSCLE INDUCED BY STRENGTH TRAINING.

    ****, sorry for the caps, was too lazy to type the stuff again。 

    Inst of Sports Medicine Copenhagen.

    The present study investigated the influence of creatine and protein supplementation on satellite cell frequency and myonuclei number in human skeletal muscle during 16 wks of heavy-resistance training. In a double-blinded design thirty-two healthy, male subjects (19-26 years) were assigned to strength training (STR) while receiving a timed intake of creatine (STR-CRE) (n=9), protein (STR-PRO) (n=8), placebo (STR-CON) (n=8) or serving as a non-training control group (CON) (n=7). Supplementation was given daily (STR-CRE : 6-24 g creatine monohydrate, STR-PRO: 20 g protein, STR-CON: placebo). Furthermore, timed protein/placebo intake were administered at all training sessions. Muscle biopsies were obtained at wks 0, 4, 8 (wk 8 not CON) and 16 of resistance training (3 days/wk). Satellite cells were identified by immunohistochemistry. Muscle mean fibre (MFA) area was determined after histochemical analysis. All training regimes were found to increase the proportion of satellite cells, however, significantly greater enhancements were observed with creatine supplementation at wk 4 (compared to STR-CON) and at wk 8 (compared to STR-PRO and STR-CON) (p<0.01-0.05). At wk 16, satellite cell number was no longer elevated in STR-CRE, while it remained elevated in STR-PRO and STR-CON. Furthermore, creatine supplementation resulted in an increased number of myonuclei per fibre and increases of 14-17% in MFA at wks 4, 8 and 16 (p<0.01). In contrast, STR-PRO showed increase in MFA only in the later (16 wks, +8%) and STR-CON only in the early (wk 4, +14%) phases of training, respectively (p<0.05). In STR-CRE a positive relationship was found between the percentage increases in MFA and myonuclei from baseline to week 16, respectively (r=0.67, p<0.05). No changes were observed in the control group (CON). In conclusion, the present study demonstrate for the first time that creatine supplementation in combination with strength training amplifies the training-induced increase in satellite cell number and myonuclei concentration in human skeletal muscle fibres, thereby allowing an enhanced muscle fibre growth in response to strength training.



    Anyways, here's the page.

    http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

  2. Board Supporter
    wastedwhiteboy2's Avatar
    Stats
    6'0"  195 lbs.
    Join Date
    Jun 2004
    Age
    41
    Posts
    2,990
    Rep Power
    3016
    Level
    38
    Lv. Percent
    59.34%
    Achievements Activity ProPosting Pro

    cool. scientific proof for what we already knew.
  3. Elite Member
    bioman's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Sep 2003
    Age
    42
    Posts
    7,714
    Rep Power
    513546
    Level
    59
    Lv. Percent
    89.71%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    aaaaaand now they will ban it.

    I've read that creatine increases the amount of intracellular IGF in skeletal muscle so that's probably the root cause for the increase in number of satellite cells.
    •   
       

  4. Registered User
    rocketscientist's Avatar
    Join Date
    Mar 2006
    Age
    46
    Posts
    227
    Rep Power
    220
    Level
    12
    Lv. Percent
    73.06%

    The finding that SC content was no longer elevated at wk 16 in STR-CRE (Fig.1) suggests that creatine supplementation accelerated the incorporation of SC derived myonuclei to the growing muscle fibres, establishing the appropriate myonuclear domain earlier than the other training groups.
    Can someone explain to me what this means? Would that indicate that, say 16 weeks of Creatine supp. would be enough, i.e. cycling creatine would be better?
  5. Doctor Science
    LakeMountD's Avatar
    Join Date
    Feb 2003
    Posts
    4,251
    Rep Power
    2557
    Level
    46
    Lv. Percent
    93.01%
    Achievements Activity ProPosting Pro

    Man if only I could find a study that told how much MGF raised satellite cell production we can see how effective creatine is in comparison

    Good post though man.
  6. Elite Member
    yeahright's Avatar
    Join Date
    Jul 2005
    Posts
    6,368
    Rep Power
    10347
    Level
    52
    Lv. Percent
    98.37%
    Achievements Activity ProPosting ProPosting Authority

    Great post - karma for you.
  7. New Member
    mtruther's Avatar
    Join Date
    Mar 2004
    Age
    36
    Posts
    214
    Rep Power
    238
    Level
    12
    Lv. Percent
    77.96%

    Quote Originally Posted by rocketscientist
    Can someone explain to me what this means? Would that indicate that, say 16 weeks of Creatine supp. would be enough, i.e. cycling creatine would be better?
    I don't think so, but don't quote me on that one.

    Satellite cells are generally non-proliferative. They serve as muscle stem cells (and release signals of cell differentiation to myonuclei) and also probably release growth factors/nutrients to muscle cells when they are under stress (e.g. weightraining).

    It looks like creatine is speeding up the differentiation process, and thus incorporating new myonuclei into the appropriate type of muscle cell at an (ultimately) faster rate than satellite cells are being produced. Hence the "decline" as satellite cells differentiate.
  8. New Member
    theshocker21's Avatar
    Join Date
    Jan 2006
    Age
    31
    Posts
    379
    Rep Power
    299
    Level
    16
    Lv. Percent
    48.86%

    Interesting study. I wish we had a library of good studies like this one to look through on this board.
  9. New Member
    mtruther's Avatar
    Join Date
    Mar 2004
    Age
    36
    Posts
    214
    Rep Power
    238
    Level
    12
    Lv. Percent
    77.96%

    Quote Originally Posted by theshocker21
    Interesting study. I wish we had a library of good studies like this one to look through on this board.
    If you'd like to try some searching on your own, go here:

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed

    You may already know about PubMed. If not, search away.
  10. New Member
    theshocker21's Avatar
    Join Date
    Jan 2006
    Age
    31
    Posts
    379
    Rep Power
    299
    Level
    16
    Lv. Percent
    48.86%

    Awesome, thanks.
  11. Banned
    Sooty's Avatar
    Join Date
    Mar 2006
    Posts
    217
    Rep Power
    0
    Level
    12
    Lv. Percent
    40%

    So does that I should take creatine eh?
  12. New Member
    theshocker21's Avatar
    Join Date
    Jan 2006
    Age
    31
    Posts
    379
    Rep Power
    299
    Level
    16
    Lv. Percent
    48.86%

    Quote Originally Posted by Sooty
    So does that I should take creatine eh?
    Are you drunk? J/k... I know what you mean
  13. Banned
    Sooty's Avatar
    Join Date
    Mar 2006
    Posts
    217
    Rep Power
    0
    Level
    12
    Lv. Percent
    40%

    haha. naw not drunk I quit drinking after i realized that im missing a liver enzyme that processes alcohol.

    when i drink, i get headache, my face turns red and swollen, and i dont feel good at all. im only 17... the last time and first time i really had alot to drink i was at madison wisconsin... pretty much had 8 beers, 6 shots, a long island ice tea and a screwdriver, and wasnt tipsy at all. i just felt really bad and my head hurt.

    Soo not drunk, just tired

    sorry for long post yipp
  14. New Member
    Speischerkater's Avatar
    Join Date
    Nov 2004
    Age
    35
    Posts
    54
    Rep Power
    150
    Level
    6
    Lv. Percent
    84.62%

    Quote Originally Posted by Sooty
    haha. naw not drunk I quit drinking after i realized that im missing a liver enzyme that processes alcohol.

    when i drink, i get headache, my face turns red and swollen, and i dont feel good at all. im only 17... the last time and first time i really had alot to drink i was at madison wisconsin... pretty much had 8 beers, 6 shots, a long island ice tea and a screwdriver, and wasnt tipsy at all. i just felt really bad and my head hurt.

    Soo not drunk, just tired

    sorry for long post yipp
    haha, a japanese friend of mine has the same problem...
  15. Banned
    Sooty's Avatar
    Join Date
    Mar 2006
    Posts
    217
    Rep Power
    0
    Level
    12
    Lv. Percent
    40%

    i know, im a quarter japanese - my mom is half and has the same prob. my gramps is 100percent also has same prob.
  

  
 

Similar Forum Threads

  1. Interesting article on Creatine
    By EZDUZIT in forum Supplements
    Replies: 45
    Last Post: 02-25-2011, 01:02 AM
  2. Replies: 20
    Last Post: 02-08-2008, 11:20 PM
  3. Replies: 17
    Last Post: 09-29-2007, 04:47 PM
  4. More Creatine Articles
    By Speischerkater in forum Supplements
    Replies: 1
    Last Post: 06-01-2006, 09:09 AM
  5. creatine article
    By bigliftsCNU in forum Supplements
    Replies: 7
    Last Post: 02-25-2003, 10:29 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in