1. Citrus aurantium, Octopamine
Seville orange (Citrus aurantium) extracts are being marketed as a safe alternative to ephedra in herbal weight-loss products, but C. aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine. Although no adverse events have been associated with ingestion of C. aurantium products thus far, synephrine increases blood pressure in humans and other species, and has the potential to increase cardiovascular events. Additionally, C. aurantium contains 6',7'-dihydroxybergamottin and bergapten, both of which inhibit cytochrome P450-3A, and would be expected to increase serum levels of many drugs. There is little evidence that products containing C. aurantium are an effective aid to weight loss. Synephrine has lipolytic effects in human fat cells only at high doses, and octopamine does not have lipolytic effects in human adipocytes.
Department of Family and Community Medicine, Lancaster General Hospital, PA 17603.
Forty-seven men with a mean age of 42 years were assigned in random, double-blind fashion to treatment with either placebo or high-dose yohimbine (peak dose, 43 mg/day). Thirty-three subjects completed the six-month program. Variables assessed throughout the study included: body weight and body mass index; total cholesterol and HDL; body fat; and fat distribution as measured both by waist-to-hip ratio and by CT scan. Treatment with yohimbine had no effect on any variable in comparison with the control group.
My notes: (I was rather disappointed to learn that yohimbine doesn’t help with weight loss. But I am still looking)
3. Caffeine anhydrous: known appetite suppressant and stimulant. I don’t think I need a study to prove this.
4. Coleus forskohlii (standardized to 20% Forskolin)
Objective: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI 26 kg/m2) men.
Research Methods and Procedure: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks.
Results: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p = 0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 ± 33.77% in the forskolin group compared with a decrease of 1.08 ± 18.35% in the placebo group.
Discussion: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.
Conclusion: Results suggest that CF (Coleus forskohlii) does not appear to promote
weight loss but may help mitigate weight gain in overweight females with apparently no clinically significant
side effects. Journal of the International Society of Sports Nutrition. 2(2):54-62, 2005
I put 2 studies because both warned that more trials would be needed to reach a better conclusion. Also both studies used obese individuals.
5. Carnitrex 100 mg
L-Carnitine. Carnitine serves as an important transporter of fatty acids from the cytosol into the mitochondria of the cell. Theoretically, increasing cellular levels of carnitine would thereby enhance transport of fats into the mitochondria and fat metabolism. For this reason, L-carnitine has been one of the most common nutrients found in various weight loss supplements. Over the years, a number of studies have been conducted on the effects of L-carnitine supplementation on fat metabolism, exercise capacity and body composition. Although there is some data showing that L-carnitine supplementation
may be beneficial for some patient populations, most well controlled studies indicate that L-carnitine supplementation does not affect muscle carnitine content, fat metabolism, and/or weight loss in overweight or trained subjects . For example, Villani et al  reported that L-carnitine supplementation (2 g/d for 8-weeks) did not affect weight loss, body composition, or markers of fat metabolism in overweight women.
My notes: I understand that Lipo 6 has “patented Carnitrex” and it includes L-Tartrate, and that doesn’t exactly equal straight L-carnitine. In regards to fat loss, I couldn’t find anything that was synergistic with L-Carnitine either.
6. Bioperine: I didn’t find too much published material on Bioperine, what I did find didn’t prove too much.