Clarification on Anacyclus

Rockzilla

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Maybe someone can help me out in trying to figure out AC dosing.
https://pdfs.semanticscholar.org/2b0...b30d6d2894.pdf
That’s the study. It used at minimum 50mg/kg of Anacyclus extract.
https://examine.com/supplements/anacyclus-pyrethrum/
I am not understanding the conversion that examine did.
They say for a 150 lb individual 550-1600mg of root extract. But a 150 person is 68 Kgs, that would mean the amount of extract they should be looking for is 3400 - 10200mgs of root extract. PR XT has 3200 mgs of Anacyclus at a 5:1 extract. A 5:1 of 3200 is 3200:640. That means 640 mgs of actual root extract. Which by examines conversion(which I don’t understand) is the lower end of the spectrum which would be for someone around my size.

Am I reading right or?
 
muscleupcrohn

muscleupcrohn

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Maybe someone can help me out in trying to figure out AC dosing.
https://pdfs.semanticscholar.org/2b0...b30d6d2894.pdf
That’s the study. It used at minimum 50mg/kg of Anacyclus extract.
https://examine.com/supplements/anacyclus-pyrethrum/
I am not understanding the conversion that examine did.
They say for a 150 lb individual 550-1600mg of root extract. But a 150 person is 68 Kgs, that would mean the amount of extract they should be looking for is 3400 - 10200mgs of root extract. PR XT has 3200 mgs of Anacyclus at a 5:1 extract. A 5:1 of 3200 is 3200:640. That means 640 mgs of actual root extract. Which by examines conversion(which I don’t understand) is the lower end of the spectrum which would be for someone around my size.

Am I reading right or?
The link doesn't seem to be working. Was that 50mg/kg in rats? If so, you have to multiply it by 0.16 (HED conversion), which gives you 8mg/kg for humans. Multiply that for an 80kg human gives you 640mg. I see one rat study on anacyclus used 50 and 100 mg/kg, so that'd be 640-1280mg for an 80kg human. As for the ratio/potency of the extract used, the study states that the yield of the extract was 3.1%. So if you take the 640mg, with a 3.1% yield, that should give you a total dose (not an extract) of about 20g. 3200mg of a 5:1 extract would be 16g, so pretty close really, especially if you're less than 80kg.
 

Rockzilla

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The link doesn't seem to be working. Was that 50mg/kg in rats? If so, you have to multiply it by 0.16 (HED conversion), which gives you 8mg/kg for humans. Multiply that for an 80kg human gives you 640mg. I see one rat study on anacyclus used 50 and 100 mg/kg, so that'd be 640-1280mg for an 80kg human. As for the ratio/potency of the extract used, the study states that the yield of the extract was 3.1%. So if you take the 640mg, with a 3.1% yield, that should give you a total dose (not an extract) of about 20g. 3200mg of a 5:1 extract would be 16g, so pretty close really, especially if you're less than 80kg.
So a PR XT serving is giving you 16g of Anacyclus total, while giving you 3200mg of extract?
 
muscleupcrohn

muscleupcrohn

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So a PR XT serving is giving you 16g of Anacyclus total, while giving you 3200mg of extract?
In simplest terms, 3200mg of that extract is equivalent to around 16g of the raw herb. 5:1 extract means it’s 5x as potent or concentrated as the source material, so you only need 1/5 the dose of what you’d need from the source material. I hope that makes sense.
 

Rockzilla

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In simplest terms, 3200mg of that extract is equivalent to around 16g of the raw herb. 5:1 extract means it’s 5x as potent or concentrated as the source material, so you only need 1/5 the dose of what you’d need from the source material. I hope that makes sense.
Ok, I understand now
 

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