Why didn't NMDAA increase testosterone?

  1. Why didn't NMDAA increase testosterone?


    Everyone thought that taking NMDAA would boost testosterone but clearly it seems to have no effect. Could be that this receptor is WRONGLY NAMED. Often times these receptors are named for the first thing that the scientist saw that binds to it!

    WHY DIDN'T NMDAA work to boost testosterone?

    Don't just look at a name and make a snap decision. Oddly enough N-Methyl-D-Aspartate may bind to it BUT NOT ACTIVATE IT! Looks like Glutamate and Glycine activate it but not NMDA. Would make some sense with this study:

    J Sports Sci Med. 2014 Jan 20;13(1):192-9. eCollection 2014 Jan.
    Heavy Resistance Training and Supplementation With the Alleged Testosterone Booster Nmda has No Effect on Body Composition, Muscle Performance, and Serum Hormones Associated With the Hypothalamo-Pituitary-Gonadal Axis in Resistance-Trained Males.

    Willoughby DS1, Spillane M1, Schwarz N1.
    Author information
    Abstract
    The effects of 28 days of heavy resistance training while ingesting the alleged testosterone-boosting supplement, NMDA, were determined on body composition, muscle strength, serum cortisol, prolactin, and hormones associated with the hypothalamo-pituitary- gonadal (HPG) axis. Twenty resistance-trained males engaged in 28 days of resistance training 4 times/wk while orally ingesting daily either 1.78 g of placebo (PLAC) or NMDA. Data were analyzed with separate 2 x 2 ANOVA (p < 0.05). Criterion measures involved body composition, muscle strength, serum cortisol, prolactin, and gonadal hormone levels [free and total testosterone, luteininzing hormome (LH), gonadotrophin releasing hormone (GnRH), estradiol], and were assessed before (Day 0) and after (Day 29) resistance training and supplementation. No changes were noted for total body water and fat mass in response to resistance training (p > 0.05) or supplementation (p > 0.05). In regard to total body mass and fat-free mass, however, each was significantly increased in both groups in response to resistance training (p < 0.05), but were not affected by supplementation (p > 0.05). In both groups, lower-body muscle strength was significantly increased in response to resistance training (p < 0.05); however, supplementation had no effect (p > 0.05). All serum hormones (total and free testosterone, LH, GnRH, estradiol, cortisol, prolactin) were unaffected by resistance training (p > 0.05) or supplementation (p > 0.05). The gonadal hormones and cortisol and prolactin were unaffected by 28 days of NMDA supplementation and not associated with the observed increases in muscle strength and mass. At the dose provided, NMDA had no effect on HPG axis activity or ergogenic effects in skeletal muscle. Key PointsIn response to 28 days of heavy resistance training and NMDA supplementation, similar increases in muscle mass and strength in both groups occurred; however, the increases were not different between supplement groups.The supplementation of NMDA had no preferential effect on augmenting testosterone or decreasing estrogen, cortisol, and prolactin.While resistance training was effective in increasing muscle mass and strength, it was not preferentially due to NMDA supplementation.At the dose provided, NMDA supplementation for 28 days combined with resistance training does not increases muscle mass and strength due to its ability to elevate endogenous testosterone levels and lower cortisol and prolactin when compared to placebo.

    Attachment 157443
    Nothing I say is medical advice and supplements only enhance and optimize your diet and exercise check with a medical professional before starting any program.
    Try Rise and Swell, the most advanced testosterone booster on the market!
    http://mindandmuscle.net/articles/pr...nd-and-muscle/


  2. cause its not your rise and swell product
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  3. Oh stop lol. Funny
    Nothing I say is medical advice and supplements only enhance and optimize your diet and exercise check with a medical professional before starting any program.
    Try Rise and Swell, the most advanced testosterone booster on the market!
    http://mindandmuscle.net/articles/pr...nd-and-muscle/

  4. Iím taking a product with NMDA and I certainly feel it working

  5. Quote Originally Posted by Rad83 View Post
    Iím taking a product with NMDA and I certainly feel it working
    Only NMDA or does it have more ingredients?
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  6. "As I sit here on the shore, watching that beautiful sailing vessel disappear over the horizon"...

  7. NMDA's biggest impact on me was always the sleep quality. Fall asleep fast and wake up feeling GOOD.
    Hi-Tech Pharmaceuticals Representative Manager

  8. You're smarter than this Eric

    Abstract:

    The effects of 28 days of heavy resistance training while ingesting the alleged testosterone-boosting supplement, NMDA, were determined on body composition, muscle strength, serum cortisol, prolactin, and hormones associated with the hypothalamo-pituitary- gonadal (HPG) axis. Twenty resistance-trained males engaged in 28 days of resistance training 4 times/wk while orally ingesting daily either 1.78 g of placebo (PLAC) or NMDA. Data were analyzed with separate 2 x 2 ANOVA (p < 0.05). Criterion measures involved body composition, muscle strength, serum cortisol, prolactin, and gonadal hormone levels [free and total testosterone, luteininzing hormome (LH), gonadotrophin releasing hormone (GnRH), estradiol], and were assessed before (Day 0) and after (Day 29) resistance training and supplementation. No changes were noted for total body water and fat mass in response to resistance training (p > 0.05) or supplementation (p > 0.05). In regard to total body mass and fat-free mass, however, each was significantly increased in both groups in response to resistance training (p < 0.05), but were not affected by supplementation (p > 0.05). In both groups, lower-body muscle strength was significantly increased in response to resistance training (p < 0.05); however, supplementation had no effect (p > 0.05). All serum hormones (total and free testosterone, LH, GnRH, estradiol, cortisol, prolactin) were unaffected by resistance training (p > 0.05) or supplementation (p > 0.05). The gonadal hormones and cortisol and prolactin were unaffected by 28 days of NMDA supplementation and not associated with the observed increases in muscle strength and mass. At the dose provided, NMDA had no effect on HPG axis activity or ergogenic effects in skeletal muscle.
    Now. What looks weird here?

    Oh, that's strange...

    Twenty resistance-trained males engaged in 28 days of resistance training 4 times/wk while orally ingesting daily either 1.78 g of placebo (PLAC) or NMDA.
    1.78g of NMDA? That's a massive likely neurotoxic dose, that can't be right.

    Lets check out the full text...

    One such product is NMDA (Muscle Warfare, Wellington, FL), a proprietary blend nutritional product that is an alleged testosterone booster.
    Muscle Warfare? I remember them, they sell pretty exclusively ****ty overpriced products. Lets check out the label.



    Hmm...where's the NMDA...

    Oh there it is, at the bottom of a 4 ingredient 35mg prop blend.

    A maximum of 8.75mg of NMDA but likely much less? Golly gee I can't even imagine why this product didn't work!
    SNS Representative - [email protected] .com

  9. Quote Originally Posted by De__eB View Post
    You're smarter than this Eric

    Abstract:



    Now. What looks weird here?

    Oh, that's strange...



    1.78g of NMDA? That's a massive likely neurotoxic dose, that can't be right.

    Lets check out the full text...



    Muscle Warfare? I remember them, they sell pretty exclusively ****ty overpriced products. Lets check out the label.



    Hmm...where's the NMDA...

    Oh there it is, at the bottom of a 4 ingredient 35mg prop blend.

    A maximum of 8.75mg of NMDA but likely much less? Golly gee I can't even imagine why this product didn't work!
    This study always makes me giggle when it pops up.
    Hi-Tech Pharmaceuticals Representative Manager
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