1/ From the full text version:
These results demonstrate that the neurosteroid, PS, dose-relatedly (0.01 and 1.0 mg/kg) decreases the preference for and interest in the odors of an estrous female. Pregnenolone sulfate at 0.01 mg/kg had no significant effect on the responses to the odors of a non-estrous female, suggesting a direct effect of PS on sexually motivated or related behavior rather than a non-specific response to female odors. Investigations of the locomotory effects of PS using a computerized multivariate open field have shown that PS at 0.01 mg/kg increases, while PS at 10 mg/kg decreases activity [[19], in preparation]. These disparate effects of PS on locomotory behavior make it highly unlikely that changes in activity contributed to the altered olfactory preferences. Pregnenolone sulfate was also observed to increase male avoidance of the odor of a predator (unpublished data), further indicating that PS does not just non-specifically alter olfactory responses
2/ Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of testosterone and testosterone metabolites, including of androsterone, etiocholanolone, 5β-androstanediol, androstadienol, and androstenol (and/or their conjugates), and this suggests that only a small amount of pregnenolone is converted into testosterone.[17][18] This is in accordance with findings on the conversion of DHEA into testosterone, in which only 1.5% of an oral dose of DHEA was found to be converted into testosterone.[17] In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase urinary levels of the progesterone metabolites pregnanediol and pregnanolone (and/or their conjugates), whereas pregnanetriol was unaffected.[17][18] Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect urinary levels of metabolites of any other steroids, including of progesteron
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