You would need to try and find someone who has run blood-work while using 2-Step "Cyclosome" (or "SEDDS) "Esterfied" Pro-Hormones to know for sure. The only data I have seen (just posted in the other Osta Plex thread) was for Sub-Lingual, 1-Step Nor-Diol in a Cyclodextrin. That *did* raise Plasma levels close to what IM Injections did - but only for 2 hours (as opposed to about a 6 day half-life for injections). You are counting on all this "new delivery/ester tech" working as advertised. The data *looks* like it should, but you need blood work to prove it - and that's hard to come by unfortunately.