The most important thing with bacopa is to just get your full daily dose in consistently, considering that the research shows more significant effects after several weeks. There is mixed evidence regarding acute nootropic effects with higher doses (think the full daily dose at one time instead of splitting the dose). It may also have some anti-anxiety effects. I like taking it with stimulants (caffeine, coffee, etc) and other nootropics (choline, huperzine, etc) in the morning, or whenever I'm taking my nootropics for the day (could be in the afternoon or another time depending on what I'm doing that day). Some people prefer to take it with some fats, but this isn't necessary.