I've read conflicting things. I've been looking at products with this ingredient, such as Dermacine and Sustain Alpha but I'd like to know more about it and it's long term effects. My main concern is it having a negative impact on bones and joints. I already have mild arthritis in my back, shoulders and wrists. That's also the main reason if you saw my other post, I was considering Sustain Alpha for long term(not cycling off) because Dermacine is supposed to have AIs. My joints bother me pretty bad now as is.