So,
Is there such a thing as building tolerance to Melatonin, even when administered on a daily basis?
Melatonin is a hormone, so the only way by which one would build tolerance would be if Melatonin receptors were downregulated through supplementation over time.
If I take Testosterone for example: someone on testerone reaplacement therapy for life doesn't build tolerance to testosterone over time so that it stops working.
In fact the opposite is true as testosterone receptors are upregulated when exogenous T is administered.
Does anyone have a study on upregulation / downregulation of Melatonin receptors through supplementation over time?
Thank you!
Is there such a thing as building tolerance to Melatonin, even when administered on a daily basis?
Melatonin is a hormone, so the only way by which one would build tolerance would be if Melatonin receptors were downregulated through supplementation over time.
If I take Testosterone for example: someone on testerone reaplacement therapy for life doesn't build tolerance to testosterone over time so that it stops working.
In fact the opposite is true as testosterone receptors are upregulated when exogenous T is administered.
Does anyone have a study on upregulation / downregulation of Melatonin receptors through supplementation over time?
Thank you!