"Despite this wide range of therapeutic activity, unfavorable pharmacokinetics (lower bioavailability) of epicatechin associated with a lower half-life and rapid clearance from the body restricts its use as a potent phyto molecule 20-22. Like other flavonoids, epicatechin is poorly absorbed across the GIT because it has multiple ring molecules that are too large to be absorbed by simple diffusion. It has poor miscibility with oils and other lipids which limit their ability to pass across the lipid rich outer membranes of enterocytes of small intestine."
Journal of Drug Discovery and Development 06/2014; 1(1):46-55.
Phosphatidylcholine complex in improving oral drug delivery of epicatechin: preparation and characterization